Arlan Richardson, PhD
Director, Barshop Institute
Professor, Department of Cellular and Structural Biology
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Oklahoma State University, Stillwater | PhD, Chemistry (Biochemistry emphasis) |
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Peru State College, Peru, Nebraska | BS, Chemistry and Biology |
Tel: 210-562-6140
Email: Richardsona@uthscsa.edu
Research Interests
The goal of my research is to understand the role of oxidative stress/damage in aging and age-related diseases, such as cancer, Alzheimer's disease, etc. My research is focused on two areas. The first area is developing and using transgenic and knockout mouse and rat models with alterations in the antioxidant defense system to study how increased or decreased oxidative damage affects survival, age-related pathology, and physiological parameters that are markers of physiological aging. Currently, we are studying transgenic/knockout mice for catalase, Cu/Zn-superoxide dismutase, Mn-superoxide dismutase, thioredoxin, and glutathione peroxidase. The second area of my research is developing assays to measure oxidative damage to specific macromolecules, in particular oxidative damage to proteins. We are currently using 2-deminisional gel electrophoresis and mass spectrometry to identify and quantify oxidative damage to specific proteins and to determine the specific amino acid residues oxidatively damaged.
Selected Publications:
- W.F. Ward, W. Qi, H. Van Remmen, W. E. Zackert, L. J. Roberts II, and A. Richardson. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J. Gerontol., 60: 847-51, 2005.
- J. Mele, H. Van Remmen, J. Vijg, and A. Richardson. Characterization of Transgenic Mice that Overexpress both Copper Zinc Superoxide Dismutase and Catalase. Antioxidants & Redox Signaling, Antioxidants & Redox Signaling, 8: 628-638, 2006.
- Pierce, E. deWaal, H. VanRemmen, A. Richardson, and A. Chaudhuri. A Novel Approach for Screening the Proteome for Changes in Protein Conformation. Biochemistry, 45: 3077-3085, 2006.
- D. C. Cabelof, Y. Ikeno, A. Nyska, R. A. Busuttil, N. Anyangwe, J. Vijg, L. H. Matherly, J. D. Tucker, S. H. Wilson, A. Richardson, and A. R. Heydari. Heterozygous Gene-Targeted Deletion of DNA Polymerase β Combined with Aging Increases Risk of Lymphoma and Adenocarcinoma and Alters Age-Related Mortality. Cancer Res., 66:7460-7465, 2006.
- R. Chaudhuri, E. M. de Waal, A. Pierce, H. Van Remmen, W. F. Ward, and A. Richardson. Detection of Protein Carbonyls in Aging Liver Tissue: A Fluorescence-based Proteomic Approach. Mech. Age. Dev., 127: 894-861, 2006.
- J. Chang, J. E. Cornell, H. Van Remmen, K. Hakala, W. F. Ward, and A. Richardson. Effect of Aging and Caloric Restriction on the Mitochondrial Proteome. J. Gerontol., 62:223-234, 2007.
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