This Program will provide graduate students with a unique curriculum designed to train them in the basic biology of aging, thereby preparing them to thrive at a unique interface of bioscience and medicine.
The program will encompass lectures and laboratory instruction in molecular, cellular, and physiological mechanisms of aging. Also covered will be theories of aging, genetic versus environmental impacts on aging rate, experimental paradigms of aging research, the biology of model organisms, demographic analysis of aging, comparative and evolutionary biology of aging, pathobiology of selected organ systems, and recent advances in genetic and environmental treatments that extend life and prevent disease.
Rochelle Buffenstein, Barshop/Physiology
Tyler J. Curiel, M.D., M.P.H., Department of Medicine
Patricia Dahia, M.D., Ph.D., Department of Medicine
Peter J. Hornsby, Ph.D., Department of Physiology
Shane Rea, Ph.D., Department of Physiology
Randy Strong, Ph.D., Department of Pharmacology
ADAMO, Martin, Biochemistry - Mechanisms of IGF-I gene expression and action.
ASMIS, Reto, Allied Health - Thiol oxidative stress in monocyte/macrophage dysfunction in dyslipidemia, diabetes, and chronic diseases.
AUSTAD, Steven, C & S Biology & Barshop Institute - Comparative biogerontology, theories of aging, evolution of aging.
BAI, Yidong, C & S Biology - Mitochondrial functions at the molecular, cellular, tissue, and animal levels.
BISHOP, Alex, C & S Biology & GCCRI - Genetics of genomic instability, homologous recombination, with age and damage.
BUFFENSTEIN, Rochelle, Physiology & Barshop Institute - Naked Mole Rats in the Study of Aging.
CHATTERJEE, Bandana, Molecular Medicine - Molecular basis of aging.
CHEN, Xiao-Dong, Comprehensive Dentistry
CLARK, Robert, Asst. VP for Clinical Research - Role of the family of NADPH oxidases in aging; the activation of NF-B and other redox-sensitive transcription factors.
CORNELL, John, Epidemiology and Biostatistics - Biostatistics/Quality of life medical analysis
DAHIA, Patricia, C & S Biology & Hematology/Medical Oncology - The role of mitochondria and aging in cancer, in particular hereditary tumors.
DAVIS, M. Duff, Research Imaging Center - Neuroimaging of Primate Brain Development; Aging in the Marmoset
DONG, Lily Q., C & S Biology - Insulin/IGF1 signaling in aging.
EATON, Benjamin A., Physiology - Using Drosophila to investigate the link between neuromuscular junction stabilization and lower motor disease
FERNANDES, Gabe, Medicine-Clinical Immunology - Immunobiology inschemia and reperfusion.
GACZYNSKA, Maria, Molecular Medicine - Role of the proteosome in protein degradation.
Alzheimer's disease, nervous system, aging, mTOR pathway, stem cell.
HART, Peter J., Biochemistry - Amyotrophic Lateral Sclerosis.
HASTY, E. Paul, Molecular Medicine - Impact of DNA repair and genomic instability in the aging process in mice.
HAZUDA, Helen, Medicine-Epidemiology - The disablement process, health disparities, type 2 diabetes, psychosocial and cultural factors in health, epidemiology.
HORNSBY, Peter, Physiology & Barshop Institute - Cell Transplantation Techniques to Probe Cellular Aging
IKENO, Yuji, Pathology & Barshop Institute - Pathology of aging and the role of oxidative stress in age-related pathology.
IMAM, Syed, Medicine - molecular mechanisms of neuronal cell death, novel cell death and cell survival pathways and their correlation with the molecular basis of Parkinson's disease.
JOHNSON, John, Physiology - Cardiovascular Control
KELLOGG, Dean, Medicine-Geriatrics - Cardiovascular aging
KRAIG, Ellen B., C & S Biology - Effects of age on immune regulation
LAFER, Eileen, Biochemistry - Neurobiology
LARSEN, Pamela L., C & S Biology - Biological mechanism(s) of aging in C. elegans.
LEACH, Robin, C & S Biology - Osteoporosis/Paget's Disease.
LECHLEITER, James D., C & S Biology - Cell survival and cell death.
LI Senlin, Medicine - Gene therapy in Parkinson's disease.
LICHTENSTEI N, Michael, Medicine - Geriatrics - Epidemiology.
LIU, Feng, Pharmacology - Molecular mechanisms in insulin signaling.
MARCINIAK, Robert, C & S Biology - Basic biology of cancer and aging and their interrelationship.
MARSHALL, Amanda, Orthopaedics - Geriatric bone health; elderly patients with osteoporotic fractures; hip and knee reconstructions.
MCALISTER-HENN, Lee, Biochemistry - Protection from metabolic oxidative stress by cytosolic sources of NADPH.
MCMANUS, Linda, Pathology - Aging muscle and role of fat invasion in its dysfunction.
MOORE, Charleen, C & S Biology - Effect of aging on chromosome structure and function.
MUSI, Nichols, Medicine - Diabetes - Molecular Biology of Insulin Action; Molecular Basis of Insulin Resistance in Aging; Pathophysiology of Sarcopenia; Cellular Effects of Exercise in Muscle.
NAYLOR, Sue, C & S Biology - Cancer genetics.
NELSON, Jim, Physiology & Barshop Institute - Glucocorticoids, stress, anti-aging interventions.
ODDO, Salvatore, Physiology
ORIHUELA, Carlos, Microbiology & Immunology - Age-associated inflammation and pneumonoccal disease through enhanced expression of plgR and PAFr in elderly.
OYAJOBI, Babatunde, C & S Biology - Biology of multiple myeloma and other cancer-induced bone diseases.
PEREIRA-SMITH, Olivia, C & S Biology & Barshop Institute - Chromatin changes and transcriptional regulation during aging of cells and genetically modified mice.
RAN, Qitao, C & S Biology & Barshop Institute - Oxidative damage and apoptosis
RAO, Hai, Molecular Medicine - Role of Ub/proteasome system in Prion disease.
RAWLS, Henry, Restorative Dentistry - Oral infections associated with elderly people.
REA, Shane, Physiology - Aging in C. elegans (Mit Mutants; Mitochondrial; Bioenergetics; Metabolomics; DNA Damage); Human Mitochondrial-associated Disorders (S. cerevisiae Models);Type II Diabetes.
REBEL, Vivienne, C&S Biology & GCCRI - Regulatory role of an aging microenvironment on normal and leukemic stem cells.
RICHARDSON, Arlan, C & S Biology & Barshop Institute - Oxidative stress/damage in aging and age-related diseases.
ROBERTS, James, Pharmacology - The role of hormones on brain development and age-related decline in brain function and memory loss.
SHARP, Z. Dave, Molecular Medicine - Gene regulation in development; cell growth control in cancer and aging.
SHIREMAN, Paula, Surgery - Muscle regeneration and stem cell differentiation in aging.
SLAGA, Thomas, Pharmacology - glucocorticoid hormones as potent inhibitors of physiological DNA synthesis in keratinocyte.
SOUSA, Rui, Biochemistry - T7 RNA polymerase as a model system to explore the conformational dynamics of transcription.
SUN, LuZhe, C & S Biology - Signal transduction, cell cycle, cell senescence, experimental therapeutics; Cancer biology.
TARDIF, Suzette, C & S Biology & Barshop Institute - Use of marmosets to study aging.
VAN REMMEN, Holly, C & S Biology & Barshop Institute - Mitochondria and oxidative stress in skeletal muscle physiology in aging and age-related disease.
WALTER, Chris, C & S Biology - DNA repair in development, aging and cancer; transgenic mouse & rat models
WARD, Walter, Physiology & Barshop Institute - Protein metabolism; protein profiling, oxidative modifications of proteins.
YEH, Chih-Ko, Dental Diagnostic Science - Oral physiology; osteoporosis.