CSB Cross Appointed Faculty

Merry L. Lindsey, Ph.D.
Assistant Professor

Department of Medicine / Division of Cardiology, UTHSCSA
(210) 567-4673
(210) 567-6960 (Fax)
DTL, Room 5.630U (Office); 5.657U (Lab)
lindseym@uthscsa.edu

My laboratory is focused on studies relating to cardiac extracellular matrix biology, specializing in changes to the matrix that are the cause or effect of pathophysiological processes. These changes include cell-matrix interactions, which both affect and react to processes involved in tissue repair. My laboratory primarily uses the murine model of myocardial infarction (MI). In addition to physiological parameters, we also measure biochemical, cell biological, and proteomic outputs. The main foci of my laboratory are: 1) the role of macrophage-derived matrix metalloproteinases (MMPs) in left ventricular (LV) remodeling post-MI; 2) the role of the cardiac fibroblast in the remodeling process; and 3) the influence of aging on LV remodeling.

Research Techniques:
Matrix metalloproteinase assays
In vivo myocardial injury models (myocardial infarction and transverse aortic constriction models)
Murine cardiovascular function analyses
Two-dimensional gel electrophoresis
Fibroblast tissue culture
Macrophage functional assays

PUBLICATIONS:
Squires, CE, Escobar, GP, Payne, JF, Leonardi, RA, Goshorn, DK, Sheats, N.J., Mains, I.M., Mingoia, JT, Flack, EC, and Lindsey, ML. (2005) Altered Fibroblast Function Following Myocardial Infarction. J Mol Cell Cardiol. Oct;39(4):699-707.

Lindsey, ML, Escobar, GP, Dobrucki, LW, Goshorn, DK, Bouges, S., Mingoia, JT, McClister Jr., DM, Su, H, Gannon, J, MacGillivray, C, Lee, RT, Sinusas, AJ, and Spinale, FG. (2005) Matrix Metalloproteinase-9 Gene Deletion Facilitates Angiogenesis Following Myocardial Infarction. Am J Physiol Heart Circ Physiol. Sep 19.

Lindsey, ML, Goshorn, D.K., Comte-Walters, S., Hendrick, J.W., Hapke, E., Zile, M.R., and Schey, K. (2005) A Multidimensional Approach to Identify Hypertrophy-Associated Proteins. Proteomics, in press.