Mailing Address:
UTHSCSA
MC7762
7703 Floyd Curl Dr.
San Antonio, TX 78229-3900

Location: Room 2.514U
Phone: (210)567-3151
Fax: (210)567-3803

Director:
James D. Lechleiter, Ph.D.
Lechleiter@uthscsa.edu

Associate Director:
Victoria Centonze Frohlich, Ph.D.
Frohlich@uthscsa.edu

Research Core/Facility Technician
Jimmy Wewer
wewer@uthscsa.edu

Mission:
To make available state-of-the-art imaging technology to investigators on the UTHSCSA campus and neighboring scientific community.

Rationale:
High-end instrumentation for acquisition and analysis of optical data is expensive and requires continued maintenance and improvements. The necessary commitment to this technology is often difficult to maintain within individual laboratories, especially when optical imaging is not a major focus for the laboratory. Therefore, the Core Optical Imaging Facility fills a critical need of UTHSCSA investigators and neighboring scientific community by offering,

• access to state-of-the-art technology for imaging of living cells, tissues, and animals.

• consultation, education and assistance regarding the theory and application of optical imaging techniques.

• technical advice on specimen preparation techniques and probe selection.

New developments in optical microscopy coupled with the vast array of bio-reagents available have made it possible to observe directly the dynamics of the molecular, chemical, structural and functional environment of cells at the cellular and sub-cellular level. In particular, fluorescence microscopy has become an essential tool for scientist to detect cellular components using antibodies, nucleic acid probes and fluorescent fusion proteins as markers and to observe physiological changes using fluorescent ion indicators.

Developments in optical microscopy coupled with the now vast array of bio-reagents available have made it possible to observe directly the dynamics of the molecular, chemical, structural and functional environment of cells at the sub-cellular level. In particular, fluorescence microscopy has become an essential tool for scientist to detect specific cellular components using antibodies, nucleic acid probes and fluorescent fusion proteins as markers and to observe physiological changes using fluorescent ion indicators.

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