Developmental biology. Mainly interested in the process of interaction between ureteric bud and metanephric mesenchyme which leads to differentiation of the mesenchyme into tubular and glomerular structure. Also interested in the rule of growth factors in the developmental process.

Microdissection of the metanephric mesenchyme. Cryosectioning of embryonic kidney and preparation for immunohistochemistry and in situ hybridization. Cell and tissue culture of embryonic kidney and study of the effect of cytokines and signal transduction pathways in these systems.

Satish Prabhu, Moshe Levi, Vangipuram Dwarakanath, Mazen Arar, Jurg Biber, Heini Murer, and NEchel Baum. Effect of Glucocorticoids on Neonatal Rabbit Renal Cortical Sodium-Inorganic Phosphate Messenger RNA and Protein Abundance. Pediatric Research, 41:20-24, 1997.

Arar M, Levi M, Baum M: Maturational Effects of Glucocorticoids on Neonatal Brush Border Membrane Phosphate Transport. Pediatric Research 35:474-78, 1994.

Arar M, Baum M, Biber J, Murer H., Levi M: Epidermal growth factor inhibits Na-Pi Cotransport in OKP Cells. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F309-F314, 1995.

Arar M., Arat, Jr. BS, Hogg RG, Seikaly MG: Etiology of sustained hypertension in children in the Southwestern United States. Pediatric Nephrology 8:186-89, 1994.

Levi M, Arar M, Kaissling B, Murer H, Biber J: Low-Pi diet increases the abundance of an apical protein in rat proximal-tubular S3 segment. Pflugers Arch 426: 5-11, 1994.

Levi M, Lotscher M, Sorribas V, Custer M, Arar M, Kaissling B, Murer H, and Biber J: Cellular mechanisms of acute and chronic adaptation of rat renal phosphate transport to alteration in dietary phosphate. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F900-F908, 1994.

Organogenesis, metanephric mesenchyme, growth factors