Basic: Evaluation of the role of thrombin receptors in the initiation and maintenance of neoinitial hyperplasia. Evaluation includes in vitro analysis using cultured human smooth muscle cell as well as in-situ from human atheroma. Clinical: Evaluation of site specific treatment of atherosclerotic lesions using new drug delivery catheters and platelet/thrombin inhibitors. The initial studies are performed in a double injury pig coronary.

Clinical studies are under way for treatment of human atherosclerotic lesions.

In vitro cultures of human atheromatous cells from primary and restnotic lesions. GLP certified laboratory for evaluation of atherosclerotic pig and rabbit models as well as dog abdominal aneurysm model. Capable of evaluating intravascular structures with ultrasound, plan and angioscopy.

Bailey SR. Kiesz RS. Intravascular stents: current applications. In: Current Problems in Cardiology. ed. OíRourke RA, McCall D Mosby, Linn 1995:20(9):pp. 615-678.

Bailey SR, Mechanisms of delivery and local drug delivery technologies. In: Semin Intervent Cardiol. ed. Serruys PW, Camennzind E, Foley D. European Heart Journal, London 1996:1(1):pp 17-23.

Bailey SR. Local drug delivery: intravascular stents, current applications. In: Seminars in Cardiovascular Medicine. ed. Topal EJ. (Submitted)

Bailey SR. Potential stent coatings: endothelial seeding. In: Endovascular Stenting. (in press).

Bailey SR, OíLeary E, Chilton R. Angioscopic evaluation of site specific administration of reopro. Catheterization and Cardiovascular Diagnosis. (in press).

Bailey SR, Russell EL, Martinez A. Evaluaion of the AVOXimeter: precision, long-term stability, and use without heparin. (in press).

Patel V. Bailey SR, OíLeary E, Hoyer MH. A novel technique for coil embolization of intercostal branch of iternal mammary artery graft. (in press).

Mego DM, Bailey SR. Applications of a novel balloon catheter during coronary angioplasty. (in press).

Weiner MA, Paige SB, Bailey SR. The effects of iron, free radiclas, and antioxidants on the development of atherosclerosis. J Am Coll Cardiol, 1A-484A:41A, 1994.

Bailey SR, Ricci D, Kiez SR, Cleman M, Fischman D, Savage M, Goldberg S, Almond D, Cabin H, Nobuyoshi M. Incidence and clinical impact of dissections after PTCA and stent placement: results from the randomized stent restenosis study. Circulation Part 2 (4)90:I-649, 1994.

Shaknovich A, Moses JW, Bailey SR, Ricci D, Kietz SR, Tierstein P, Schatz RA, for STRESS Investigators. Lenox Hill Hospital, New York, NY. Subacute stent thrombosis in the stent restenosis study (STRESS): clinical impact and predictive factors. Circulaion Part 2 (4)90:I,650, 1994.