Paula K. Shireman, M.D.
Assistant Professor
Department of Surgery
Section of Vascular Surgery
| Location: | MED, Room 219E |
| Phone: | (210) 567-5715 |
| Fax: | (210) 567-1762 |
| E-mail: | shireman@uthscsa.edu |
Research Interests:
Study of the basic mechanisms of collateral artery formation
in the presence and absence of diabetes. Using a rabbit and mouse
hind-limb ischemia model, we can quantitate the number of collateral
arteries using arteriography and hemodynamic changes using fluorescent
microspheres to measure regional blood flow. Currently we are
interested in the role of inflammatory cells in the regulation
of collateral artery formation.
Unique Technical and Clinical Research Capabilities/Instrumentation:
Tissue culture, rabbit and mouse model of hind-limb ischemia,
quantitation of perfusion using fluorescent microspheres, arteriography,
histology.
Publications:
Shireman PK, McCarthy WJ, Pearce WH, Kwaan HC: Elevated levels
of plasminogen activators in diseased aorta. Surgical Forum 1995;
Vol XLVI:362-364.
Shireman PK, McCarthy WJ, Pearce WH, Patterson BK, Shively
VP, Cipollone M, Tamarina N, Verrusio EN, Kwaan HC: Elevated levels
of plasminogen activator inhibitor type 1 in atherosclerotic aorta.
J Vasc Surg 1996;23:810-18.
Shireman PK, McCarthy WJ, Pearce WH, Shively VP, Cipollone
M, Yao JST: Plasminogen activator levels are influenced by location
and varicosity in greater saphenous vein. J Vasc Surg 1996; 24:719-24.
Shireman PK, McCarthy WJ, Pearce WH, Shively VP, Cipollone
M, Kwaan HC: Elevations of tissue type plasminogen activator and
differential expression of urokinase type plasminogen activator
in diseased aorta. J Vasc Surg 1997; 25:157-64.
Shireman PK, Hampton B, Burgess WH, Greisler HP: The FGF-1
mutant S130K induces heparin-independent smooth muscle cell proliferation
and is resistant to thrombin degradation in fibrin glue. Surgical
Forum 1998; XLIX:348-50.
Shireman PK, Hampton B, Burgess WH, Greisler HP: Modulation
of vascular cell growth kinetics by local cytokine delivery from
fibrin glue suspensions. J Vasc Surg 1999;29:852-61.
Shireman PK, Xue L, Maddox E, Burgess WH, Greisler HP: The
S130K fibroblast growth factor-1 mutant S130K induces heparin-independent
proliferation and is resistant to thrombin degradation in fibrin
glue. Submitted to J Vasc Surg. 2000;31:382-90.
Shireman PK, Greisler HP: Mitogenicity and release of Vascular
Endothelial Growth Factor with and without heparin from fibrin
glue. Submitted to J Vasc Surg. 2000;31:936-43.
Key Words:
Collateral circulation, Diabetes mellitus, Arteriosclerosis,
MCP-1