|
Microbiology & Immunology Faculty
Research | Publications | Lab Members
 |
Santanu Bose, Ph.D.
|
Research
Research Interests:
a) Host antiviral defense mechanism: innate immune antiviral and inflammatory response against respiratory RNA viruses like human respiratory syncytial virus (RSV), influenza A virus and parainfluenza viruses, b) Virus based anti-cancer therapeutics.
Following are the undergoing projects in the laboratory:
Innate immune antiviral and inflammatory response against respiratory viruses - We are studying the innate immune response (the first line of defense against pathogens) against RSV, influenza A and human parainfluenza viruses. These respiratory viruses are highly pathogenic and cause diseases (pneumonia, bronchiolitis) in children/infants and elderly. Since no effective antiviral therapy and vaccine exists for majority of these viruses, we are investigating the mechanism of host derived antiviral immune response to identify novel antiviral molecules/pathways, which could be potentially developed as effective antiviral therapy. Our studies on innate immune response constitutes investigation of the role of two signaling pathways, NF-kappa B and interferon induced JAK/STAT pathways in establishing an anti-viral state. The long-term goal of our research is to identify and characterize a) the molecules that play a critical role in activation of these pathways and, b) the anti-viral factors that are induced by NF-kappa B and JAK/STAT signaling cascades. In addition, we are examining the molecular mechanism that triggers inflammation in the infected lungs, which significantly contribute to immuno-pathogenesis and development of disease state like pneumonia.
In addition, we are examining the molecular mechanism that triggers inflammation in the infected lungs, which significantly contribute to immuno-pathogenesis and development of disease state like pneumonia.
Molecular virology of respiratory viruses -We are also interested in understanding the basic cell-biology mechanism of virus infection process by studying virus entry, trafficking and budding. These studies involve identification of novel cellular (host) factors that facilitate virus infection.
Development of anti-cancer oncolytic RNA viruses- We have recently identified a RNA virus that has "oncolytic" property, i.e. it kills tumor cells, but not normal cells. We are generating genetically engineered "safe" and "efficient" recombinant viruses as anti-cancer therapeutic agent for virus-based cancer therapy called virotherapy.
In summary, our laboratory encompasses several aspects of cell and molecular biology/virology with emphasis on innate immune antiviral signal transduction pathway, inflammation during virus infection, virus-host interaction, and development of virus-based anti-cancer therapeutics.
Publications
-
Sabbah, A., Chang, T., Harnack, R., Frohlich, V., Dube, P.H., Tominaga, K., Xiang, Y. & Bose, S. Activation of innate immune antiviral response by NOD2. Nature. Immunol.
Advance online publication, Aug 23, 2009; doi:10.1038/ni.1782. -
Echchgadda, I; #Kota, S; DeLa Cruz, I; Sabbah, A; Mgbemena, V; Chatterjee, B & Bose, S. Anti-cancer oncolytic activity of respiratory syncytial virus. Cancer. Gene. Ther.
Advance online publication, May 15, 2009; doi:10.1038/cgt.2009.34. - Kota, S; Sabbah, A; Chang, T. H; Harnack, R; Xiang, Y; Meng, Y & Bose, S. Role of human beta-defensin-2 during tumor necrosis factor-a/NF-kB mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283:22417-22429 (2008).
- Basu, M., Maitra R.K. Xiang, Y., Meng, X., Banerjee, A.K., Bose, S.. Inhibition of vesicular stomatitis virus infection in epithelial cells by alpha interferon-induced soluble secreted proteins. J. Gen. Virol. 87(Pt 9):2653-2662 (2006).
- Dong, B., Zhou, Q., Zhao, J., Zhou, A., Harty, R.N., Bose, S., Banerjee, A., Slee, R., Guenther, J., Williams, B.R., Wiedmer, T., Sims, P.J. and Silverman, R.H. Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J. Virol. 78:8983-8993 (2004).
- Bose, S. and Banerjee, A.K. β-catenin associates with human parainfluenza virus type 3 ribonucleoprotein complex and transcriptionally activates viral genome in vitro. Gen. Expr. 11:241-249 (2004).
- Zheng, S., Xu, W., Bose, S., Banerjee, A.K., Haque, J. and Erzurum, S. Impaired nitric oxide synthase (NOS) 2 signaling pathway in cystic fibrosis airway epithelium. Am. J. Physiol. 287:L374-L381 (2004).
- Bose, S., Basu M. and Banerjee, A.K. Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells. J. Virol. 78:8146-8158 (2004).
- Bose, S., Kar, N., Maitra, R., Didonato, J. and Banerjee, A.K. Temporal activation of NF-κB regulates an interferon independent innate anti-viral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA 100:10890-10895 (2003).
- Bose, S., Mathur, M., Joshi, N., Bates, P. and Banerjee, A.K. Requirement for cyclophilin A for the replication of vesicular stomatitis virus New Jersey serotype. J. Gen. Virol. 84:1687-1699 (2003).
- Bose, S., and Banerjee, A.K. Innate immune response against non-segmented negative strand RNA viruses. J. Interferon. Cytokine. Res. 23:401-412 (2003).
- Bose, S. and Banerjee, A.K. Role of Heparan Sulfate in human parainfluenza virus type 3 infection. Virology. 298:73-83 (2002).
- Bose, S., Mular, A. and Banerjee, A.K. Polarity of human parainfluenza virus type 3 infection in polarized human lung epithelial A549 cells: Role of microfilament and microtubule. J. Virol. 75:1984-1989 (2001).
Lab Members
Lab Rooms: 5.011V, 5.016V
