Microbiology & Immunology Postdoctoral Fellows

  Research | Publications | Awards | Posters & Presentations

Sankaralingam Saikolappan Pani lab - RAHC Tel: (210) 563-6431 Fax: (210) 567-6612 Email: Sankaralingam

Education

University Of Madras, Chennai

Research

Research interests:

• Developing of novel gene knock out vaccines for Mycobacterium tuberculosis.
• Role of Ag85B in improving the efficacy of existing BCG vaccines for tuberculosis.
• Study of molecular pathogenesis of mycobacteria and mechanisms of intracellular survival, latent infection, and response to various oxidative and osmotic stress.
• Study of molecular pathogenesis of Mycoplasma genitalium and mechanisms of intracellular survival

Publications

• A fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages. Sankaralingam Saikolappan, Jaymie Estrella, Smitha J Sasindran, Arshad Khan, Lisa Y Armitige, Chinnaswamy Jagannath, and Subramanian Dhandayuthapani. PLoS ONE. 2012 May 7(5).
• Methionine Sulfoxide Reductase A (MSRA) deficient Mycoplasma genitalium shows decreased interaction with host cells. Kishore Das, Georgina De la Garza, Shivani Maffi, Sankaralingam Saikolappan and Subramanian Dhandayuthapani. PLoS ONE. 2012 Apr 7(4).
• OsmC proteins of Mycobacterium tuberculosis and M. smegmatis protect against organic hydroperoxide stress. Sankaralingam Saikolappan, Kishore Das, Smitha J. Sasindran, Chinnaswamy Jagannath, Subramanian Dhandayuthapani.Tuberculosis 91 (2011) S119-S127.
• Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis. Sasindran SJ, Sankaralingam Saikolappan, Scofield VL, Dhandayuthapani S. BMC Microbiol. 2011 Feb 25;11:43.
• Mycoplasma genitalium mg454 Gene Product Resists Killing by Organic Hydroperoxides. Sankaralingam Saikolappan, Smitha J. Sasindran, Hongwei D. Yu, Joel B. Baseman and Subramanian Dhandayuthapani. J Bacteriol. 2009 Aug 28.
• Methionine sulfoxide reductase B (MsrB) of Mycobacterium smegmatis plays a limited role in resisting oxidative stress. Subramanian Dhandayuthapani, *, Chinnaswamy Jagannath, Celina Nino, Sankaralingam Saikolappan, Smitha J. Sasindran. Tuberculosis 89 (2009) S1, S26-S32
• Methionine sulfoxide reductases and virulence of bacterial pathogens. Smitha J Sasindran, Sankaralingam Saikolappan and Subramanian Dhandayuthapani., Future Microbiol. (2007) 2(6): 619-630.
• Report of skin test reactivity to Aspergillus and other allergens in Chennai. SaiKolappan S, Moses.G, Subramanian.S, Rajendran.P, Kanthesh B.M. Indian Journal of Applied Microbiology, (2002); 2(1): 49.
• Seroprevalence of syphilis in apparently healthy Irula tribals of TN. Kanthesh B.M, Rajendran.P, SaiKolappan S, Vikram Reddy, Aslam M, Latha J., Indian journal of Medical Research (Nov 2004).

Awards

Posters and Presentations

• Peroxide reductase activity of recombinant OsmC protein of Mycobacterium tuberculosis. Presented at the annual Congress of American Society of Microbiology (ASM) held at NewOrleans, May 2011.
• MG454 Gene Product of Mycoplasma genitalium Provides Resistance to Killing by Organic Hydroperoxides. Presented at the annual Congress of American Society of Microbiology (ASM) held at Boston, June 2008.