Microbiology & Immunology Postdoctoral Fellows
University of Texas Health Science Center at San Antonio
Mycoplasma genitalium is an important sexually transmitted pathogen responsible for nonchlamydial, nongonoccocal urethritis in men. It has also been implicated in inflammatory reproductive tract diseases in women, including cervicitis, endometritis, pelvic inflammatory disease, and tubal factor infertility. Mycoplasma genitalium can invade host cells and establish perinuclear and intranuclear localization. My research has been centered on the identification of gene products of Mycoplasma genitalium that mediate the interaction between mycoplasma and host cells. The identification of these molecules will unravel the intracellular trafficking of Mycoplasma genitalium and help us understand how this pathogen can establish persistent infection. Molecules identified can be used as therapeutic targets to interrupt or prevent disease progression.
- Zhang W, Baseman JB. Transcriptional regulation of MG_149, an osmoinducible lipoprotein gene from Mycoplasma genitalium. Mol Microbiol. 2011 Jul;81(2):327-39. Epub 2011 Jun 22.
- Zhang W, Baseman JB. Transcriptional response of Mycoplasma genitalium to osmotic stress. Microbiology. 2011 Feb;157(Pt 2):548-56. Epub 2010 Nov 4.