Microbiology & Immunology Graduate Student
Research | Publications | Awards | Posters & Presentations
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Victoria Mgbemena
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Education
B.S., Biology, Baylor University, Waco, Texas
Research
Research interests:
Innate Immune Regulation During Respiratory RNA Virus Infection
For this project we are studying how the host responds to respiratory virus infection by producing immune factors which contribute to disease pathogenesis and virus evasion.
COSTAR supported research has led to identification of Kruppel-like factor 6 (KLF6) as a transcription factor which can bind to the promoters of iNOS and TGF-β genes during respiratory RNA virus infection. Trans-activation of iNOS gene during Influenza A virus infection results in iNOS enzyme production, leading to NO release and increased apoptosis. Trans-activation of TGF-β gene during respiratory syncytial virus (RSV) infection leads to increased TGF-β secretion, and increased RSV replication in human lung epithelial cells.
Publications
- Echchgadda, I; Kota, S; DeLa Cruz, I; Sabbah, A; Chang, T; Mgbemena, V; Chatterjee, B & Bose, S. Anti-cancer oncolytic activity of respiratory syncytial virus. Cancer. Gene. Ther. 16: 923-935 (2009). PMCID: PMC2813688
- Mgbemena, V; Segovia, J; Chang, T & Bose, S. Krüppel-like factor 6 regulates transforming growth factor-beta gene expression during human respiratory syncytial virus infection. Virology. J. 8:409 (2011). PMCID: PMC3170303
- Chang, T; Segovia, J.A; Sabbah, A; Mgbemena, V & Bose, S. Role of cholesterol-rich lipid raft in human respiratory syncytial virus infection. Virology. 422: 205-211 (2012). PMCID: PMC3249476
- Segovia, J; Sabbah, A; Mgbemena, V; Tsai, S; Chang, T; Berton, M; Morris, I. R; Ting, J. P & Bose, S. TLR2/MyD88/NF-kappa B pathway, reactive oxygen species, K+ efflux activates NLRPR3/ASC inflammasome during respiratory syncytial virus infection. PLoS. One. 7:e29695 (2012). PMCID: PMC3266238
- Mgbemena, V; Segovia, J; Chang, T; Tsai, S-Y; Cole, G. T; Hung, C-Y & Bose, S. Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. (2012). PMID:22711891 [Epub ahead of print].
- Hinojosa,CA.; Mgbemena, V; Friedline, S; Austad, SN; Miller, RA; Bose, S; Orihuela, CJ. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. (revised manuscript submitted)
Awards
05/2004 to 08/2005 - Alief Paraprofessional Association Scholarship
08/2004 to 08/2008 - Baylor President's Scholarship
08/2004 to 08/2008 - Houston Livestock Show and Rodeo Merit Scholarship
08/2008 - Honors Thesis, Honors College, Baylor University
10/2011 - Recipient, The Council for Excellence in Women's Health Scholarship, University of Texas Health Science Center at San Antonio
03/2012 - Second Place, Poster Presentation, University of Texas Health Science Center at San Antonio 30th Annual Dental Science Symposium
Training Grants
08/2009 to 07/2012 - NIH predoctoral fellowship from Craniofacial Oral-Biology Student Training in Academic Research (COSTAR) programPosters & Presentations
- Mgbemena, V. (2008) "Dynamic Modeling of Catalysis Using Rapid Prototyping" (Oral presentation) National Conference for Undergraduate Research, Salisbury, Maryland.
- Mgbemena, V., Chang, T.H., and Bose, S. (2009) "Kruppel like factor 6 (KLF6) is required for inducible nitric oxide synthase (iNOS) expression in human influenza A (H1N1) virus infected cells" (Poster) UTHSCSA Graduate Student Recruitment Weekend, 2010, San Antonio, TX.
- Mgbemena, V., Chang, T.H., and Bose, S. (2009) "Krüppel-like factor 6 (KLF6) is required for inducible nitric oxide synthase (iNOS) expression in human influenza A (H1N1) virus infected cells" (Poster) NIDCR Trainee Workshop, March 3-5, 2010, Bethesda, MD.
- Mgbemena, V., Chang, T.H., Segovia, J. and Bose, S. (2010) "Krüppel-like-factor 6 regulates host defense against influenza A virus infection" (Poster) General Session for the IADR/AADR, March 16-19, 2011, San Diego, CA.
- Mgbemena, V; Segovia, J; Chang, T; Tsai, S-Y; Cole, G. T; Hung, C-Y & Bose, S. (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. (Poster) 30th Annual Dental Science Symposium, April 11, 2012, San Antonio, TX.
