Science policy focus of
Burroughs Wellcome Foundation Lecture

Dr. Schachman, professor of the Graduate School Department of Molecular and Cell Biology at the University of California at Berkeley, was awarded a visiting professorship from the Burroughs Wellcome Foundation because of his unique knowledge of and perspective on the biomedical scientific environment.

A graduate of Princeton University and the Massachusetts Institute of Technology, Dr. Schachman is the recipient of honors from the American Society for Biochemistry and Molecular Biology, the Federation of American Societies for Experimental Biology, the American Society of Biological Chemists and the American Chemical Society, among many others.

Dr. Schachman also has served in an editorial capacity for such publications as Virology, the Archives of Biochemistry and Biophysics, Biochemical and Biophysical Research Communications, Analytical Biochemistry, Biochemistry, the Annual Reviews of Biochemistry and the Journal of Biological Chemistry.

Dr. Schachman's experience with NIH and the political institutions and federal funding agencies involved with the scientific community is expected to provide Health Science Center researchers with insights into institutional research policies and how the scientific community should relate to the organizations, both political and societal, that determine funding.

The lecture will begin at 3:30 p.m. in lecture hall 3.104A with a wine and cheese reception to follow at 5 p.m. The Burroughs Foundation, the Beckman Coulter Inc., and the Health Science Center Department of Biochemistry will sponsor the event, which is open to the public.

The Burroughs Wellcome Foundation is a private,independent foundation established to further the medical sciences by supporting research and educational activities.

A new hope for Lou Gehrig's disease patients

The "creeping paralysis" of ALS has taken a toll on Holguin, who has slurred speech and problems walking. She uses a wheelchair because of a year-old broken ankle that has not healed properly because of the muscle degeneration she is experiencing. But even in the midst of the changes taking place in her body, the 64-year-old former nurse has not lost her smile or her spirit.

"I feel all right. It is not a painful disease," she said. "But it is no fun to be unable to do activities and things you were able to do quite well before."

Faced with an uncertain future and little in the way of treatment for the disease, Holguin opted to join 20 ALS patients at the Health Science Center in an international study of an experimental drug with the potential to slow down or stop muscular degeneration, and possibly even promote the growth of motor neurons damaged by the disorder.

Principal investigator Dr. Carlayne Jackson, a neurologist and associate professor in the Department of Medicine, began working with ALS patients in November on the clinical trial, which will last 18 months and is co-sponored by the Health Science Center and the South Texas Veterans Health Care System. The drug, a genetically engineered growth factor known as brain-derived neurotrophic factor (BDNF), has shown encouraging results in cell cultures and animal models. Earlier human trials did not fare as well because investigators believe the drug, which was initially injected subcutaneously, was unable to penetrate into the nervous system because of the blood-brain barrier that protects the brain and spinal cord from toxins.

In an effort to remedy past problems with drug delivery, the current trial has coupled BDNF with a Medtronic pump system the size of a hockey puck. The device is surgically implanted in the abdomen and filled with medication, which is delivered through a catheter directly into the cerebrospinal fluid. The pump is drained and refilled with doses of BDNF every month.

The clinical trial is placebo-controlled, with two-thirds of the patients receiving the drug and the other participants receiving a buffered saline solution. Patient response will be tracked during an 18-month period and investigators will then determine if the drug and pump systems are safe and effective treatments.

Laura Holguin is betting on it. She has a vested interest in the study, not just for herself, but for her six children, who all have a 50 percent chance of being diagnosed with familial ALS later in life. Five percent to 10 percent of all ALS patients suffer from the familial form of the disease, which is passed down from parents to children.

"Enrollment in any type of clinical trial provides people with some sense of hope that something is being done and that even if this isn't the drug that cures this disease, the information we receive will continue to lead us in the direction of finding a treatment," Dr. Jackson said.

"If this drug can help her immediately then that is the real push, but if it can help others in the future--that is ideal," said Laura's daughter, Mary Holguin.

If the clinical trials prove successful, the drug and pump system may be beneficial in treating other neurological disorders. Dr. Jackson said she believes researchers are closer than ever to a viable treatment for ALS patients, and clinical trials such as this one, are pointing the way ahead.

Laura Holguin, who was diagnosed with Lou Gehrig's disease, is participating in a novel study being conducted by Dr. Carlayne Jackson, left. Erin Iturriga, a registered nurse, assists Dr. Jackson.

Funding friends

Parking expansion process updated
to include safety measures

"We know the parking assignment process was not perfect, and we apologize for the long waits in line. We would like everyone to realize this was a manual process and, yes, there were some mistakes." Ferrara said. "The parking office staff continues to work through the waiting lists in an effort to move people to their preferred locations."

Ferrara emphasized that this was a one-time effort and that no one on staff will have to go through the registration procedure again. Anyone who wants to make a change can put his or her name on a waiting list. Students will need to register for parking each fall, as has always been the case, however, a firm process has not yet been defined. No one--faculty, staff or students--will be denied a permit. Anyone who would like a permit should go to the parking office and fill out an application.

In response to concerns that not enough reserved spaces were made available, the parking office staff is working to increase the number of reserved spaces in each lot. No lot or zone, however, will be fully reserved. On average, about 30 percent of each lot will be reserved.

"Those who didn't get reserved spaces but who put their names on waiting lists will be offered reserved spots, perhaps not in their lots of choice, but in the zones they requested," he said.

Those who prefer to be in the lot first specified will be able to stay on the waiting list until a space in that lot becomes available. In addition, Ferrara proposed that non-reserved lots be oversold by 20 percent to the Parking and Traffic Safety Committee. The Committee voted unanimously on Oct. 20 to approve the recommendation. "Those lots are never at full capacity because our work force is very transient," he said. To date, none of the lots have been oversold, he added.

While faculty and staff have already been offered an opportunity to move to the main campus, this also will allow all students who do not want to park in Lot 17 the opportunity to relocate. To address the safety concerns at Lot 17, the committee approved a process that will first allow those in Lot 17 (Zone V) to move to Zone IV on the main campus. That will allow students to be no further away from campus buildings than they were in the old system.

A project also is underway to address safety concerns at Lot 17. A roadway is under construction that will connect the lot to the Allied Health Sciences/Research and McDermott buildings, making shuttle service more efficient and allowing for access to Lot 17 from Medical Drive or Floyd Curl Drive.

The new project should be completed within 30 days, Ferrara said. In the meantime, lights and an emergency phone were temporarily installed earlier this week. As an ongoing security measure, the lot is patrolled at least four times an hour, and shuttles will run every 10 to 20 minutes.

Newly Granted

The following new and competitive renewal grants and awards were recorded in the Office of Grants Management for August 1999.

"Estrogen and Intercellular Communication in Bone Osteocytes," Dr. Jean Jiang, American Federation for Aging Research (AFAR), $39,000, 1 year.

"Advanced Practice Public Health Nurse--MSN/MPH Partners," Dr. Beverly Robinson, The University of Texas Health Science Center--Houston/Department of Health and Human Services (DHHS)/Health Resources and Services Administration (HRSA), $35,695, 1 year.

"Water Fluoridation and Texas Health Steps (EPISDT-Medicaid) Cost in Texas," Dr. John Brown, Texas Depart-ment of Health (TDI), $8,527, 1 year.

"Angulation Error Analysis in Longitudinal Radiography," Dr. Brent Dove, Electro Medical Systems, $10,200, 1 year.

"Clinical Evaluation of X-ray Aiming Device for Longitudinal Radiographic Analysis," Dr. Brent Dove, Electro Medical Systems, $71,000, 1 year.

"Grants for Geriatric Education Centers," Dr. Michele Saunders, DHHS/HRSA, $755,488, 3 years.

"Antinociceptive Effects of Propiram and its Metabolites," Dr. Christopher Flores, Globomax LLC, $57,600, 1 year.

"Family Practice Residency Program Pilot Project Grant," Dr. Joshua Freeman, Texas Higher Education Coordinating Board (THECB), $197,400, 1 year.

"Toward the Development and Establishment of a Nurse Workforce Data System," Dr. Antonio Furino, Texas Nurses Foundation (TNF), $20,000, 1 year.

"Family Practice Residency Program," Dr. Janet Realini, THECB, $492,336, 1 year.

"The BRCA Genes, the DNA Repair Machinery and Cancer," Dr. Phang-Lang Chen, The V Foundation, $50,000, 2 years.

"Molecular Biology of the Synapse," Dr. Eileen Lafer, National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS), $36,250, 2 years.

"Basic Mechanisms Underlying Neurotransmission," Dr. Eileen Lafer, Muscular Dystrophy Association, $197,078, 3 years.

"Medical Hispanic Center of Excellence," Dr. Martha Medrano, DHHS/HRSA, $1,547,529, 1 year.

"1999 UHS Agreement," Dr. James Young, University Health System, $3,812,260, 1 year.

"Intergovernmental Personnel Agreement (IPA) for Rosemarie Plaetke," Dr. Sherry Abboud, South Texas Veterans Health Care Sytem (STVHCS), $35,152, 1 year.

"IPA for Cheresa Calhoun," Dr. Sherry Abboud, STVHCS, $42,508, 2 years.

"Phase 1 Dose-Escalation Study of the Safety and Pharmacokinetics of Recombinant Human CD40 Ligand in Cancer Patients," Dr. Jeanne Anderson, Cancer Therapy and Research Center (CTRC)/Immunex, $35,040, 2 years.

"A Prospective, Randomized, Double-Blind, Multi-Center Study Comparing the Effects of Atorvastatin vs. Pravastatin on the Progression/Quantification of Coronary Atherosclerotic Lesions as Measured by Intravascular Ultrasound," Dr. Steven Bailey, Covalent Group Inc./Parke Davis, $220,000, 9 months.

"Predictors of Neuropsychiatric SLE--Supplement," Dr. Robin Brey, NIH/NINDS, $30,000, 2 years.

"Annual San Antonio Breast Cancer Symposium," Dr. Charles Coltman, NIH/National Cancer Institute (NCI), $75,000, 5 years.

"IPA for George E. Crawford," Dr. George Crawford, STVHCS, $11,000, 5 months.

"A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Effect of A-100 on Glycemic Control in Overweight Type-2 Diabetic Subjects Treated with Metformin Alone or Metformin in Combination with Sulfonylurea," Dr. Ralph DeFronzo, Amgen, $60,000, 10 months.

"The Disablement Process in Rheumatoid Arthritis," Dr. Agustin Escalante, NIH/National Institute of Child Health and Human Development (NICHHD), $1,539,634, 5 years.

"Effect of Antioxidant Fermented Cellulose Products on Animals," Dr. Gabriel Fernandes, Advanced H2O, $12,000, 11 months.

"Cardiac Disease Management Program," Dr. Gregory Freeman, United States Department of Defense (DOD), $4,000,000, 3 years.

"IPAA for Zhongding Lu," STVHCS, $60,132, 1 year.

"The Role of Estrogen Receptor-A in Breast Cancer Metastases to Bone," Dr. Theresa Guise, Dept. of the Army, $280,764, 3 years.

"Mechanisms of Action in DPP Intervention," Dr. Steven Haffner, University of Tennessee, $8,186, 1 year.

"Study of Intravenous Immunoglobulin in Generalized Myasthenia Gravis," Dr. Carlayne Jackson, Food and Drug Administration (FDA), $26,000, 1 1/2 years.

"Role of PTH Receptor in Breast Cancer Metastasis to Bone," Dr. Sanna-Maria Kakonen, Dept. of the Army, $126,000, 3 years.

"IPA for Tazuko K. Hymer," Dr. Michael Katz, STVHCS, $41,859, 1 year.

"IPA for April Lynn Sousa," Dr. Michael Katz, STVHCS, $30,959, 1 year.

"Mechanisms of Visceralization in Leishmaniasis," Dr. Peter Melby, NIH, $25,000, 1 year.

"Breast Cancer Adjuvant Therapy in Older Women," Dr. Peter Ravdin, Case Western Reserve University/NIH, $295,110, 1 year.

"Osteoclasts from Transgenic Mice," Dr. David Roodman, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), $1,194,689, 1 year.

"Postdoctoral Fellow Salary Support," Dr. Joel Baseman, CTRC, $30,618, 1 year.

"Graduate Student Salary Support
for Rene Alvarez," Dr. Joel Baseman, Georgia State University, $20,160, 1 year.

"Testing for Mycoplasma Infection: Replicability of NGT and FPCR," Dr. Joel Baseman, SRA Life Science Inc., $135,794, 5 months.

"Graduate Student Salary Support for Azeneth Barrera," Dr. Joel Baseman, Southwest Foundation for Biomedical Research, $4,493, 1 year.

"Conference Support for the Portland Bone Symposium," Dr. John Schmitz, Whitaker Foundation, $5,000, 1 year.

"Collagen Structure and the Toughness of Bone," Dr. Xiaodu Wang, NIH/NIAMS, $210,965, 1 year.

"Prevalence of Prothrombin Gene Mutation in Victims of Fatal Pulmonary Embolism," Dr. Margaret Gulley, Southern Medical Association, $2,500, 1 year.

"IPA for Jeffrey I. Kreisberg," Dr. Jeffrey Kreisberg, STVHCS, $11,990, 5 months.

"Glucose-Dependent Phenotypic Alterations in Diabetic (IDDM) PMN," Dr. Linda McManus, Juvenile Diabetes Foundation International, $50,000, 1 year.

"Neonatal Dietary Programming of Bile Acid Metabolism," Dr. Glen Mott, Southwest Foundation for Biomedical Research, $13,614, 1 year.

"PACTG 367-Medical Chart Abstraction of HIV-Infected Pregnant Women and Their Children," Dr. Terence Doran, Social and Scientific Systems Inc., $3,050, 1 year.

"An Open-Label, Comparative Study of the Effect of Sirolimus vs. Standard Treatment Clinical Outcomes and Histological Progression of Allograft Nephropathy in High-Risk Pediatric Renal Transplant Patients," Dr. Ihsan Elshihabi, New York Medical College, $64,000, 5 years.

"Baboon and Rhesus Herpes Viruses," Dr. Hal Jensen, Southwest Foundation for Biomedical Research, $32,821, 1 year.

"A Functional Role for Chromosome 18 in Prostate Cancer Metastasis," Dr. Teresa Johnson-Pais, CTRC, $19,132, 1 year.

"Coinstallation of Surfactant and Budesonide as well as Surfactant and Dibutyryl Can Increase the Production of Surfactant Proteins in Premature Ventilated Rabbits," Dr. Steven Seidner, American Academy of Pediatrics, $2,500, 1 year.

"Clinical Protocol for Phase 3, Double-Blind, Randomized Comparison of Two Administration Schedules of Leridistim (SC-70935) vs. G-CSF in the Prevention of Secondary Febrile Neutropenia in Pediatric Cancer Patients," Dr. Steven Weitman, ILEX/G.D. Searle & Co., $67,750, 2 years, 4 months.

"Oral Treponemes in Periodontal Diseases: HIV and ANUG," Dr. Jeffrey Ebersole, NIH/ National Institute of Dental & Craniofacial Research (NIDCR), $995,845, 10 months.

"Non-Human Primate Studies of Oral Disease," Dr. Jeffrey Ebersole, Procter & Gamble, $306,525, 5 months.

"Hallucinogens Pharmacology on 5-HT Receptor Subtypes," Dr. Kelly Berg, Mount Sinai Medical College, $120,561, 1 year.

"Novel Actions of Inverse Agonists," Dr. William Clarke, NIH/National Institute of General Medical Sciences (NIGMS), $836,544, 5 years.

"A Randomized, Crossover Study to Evaluate the Effects of Venlafaxine and Nefazodone on the Pharmacokinetics of Alprazolam," Dr. Larry Ereshefsky, Wyeth-Ayerst, $189,504, 1 1/2 years.

"Special Chemistry Analysis," Dr. Yui-Wing Francis Lam, Texas Department of Mental Health/Mental Retardation (MH/MR), $105,600, 1 year.

"IPA for Elizabeth Fernandez," Dr. John Strong, STVHCS, $44,808, 1 year.

"Nathan Shock Aging Center," Dr. Arlan Richardson, NIH/National Institute on Aging (NIA), $80,000, 9 months.

"Research on Individual Sensitivity to Benzodiazepines/NRSA," Dr. John Roache, NIH/National Institute on Drug Abuse (NIDA), $37,152, 11 months.

"Hybridization Oven for Research Exploring Molecular Changes in Cells Exposed to Various FORS of Microwave Radiation," Dr. Martin Meltz, AFOSR, $5,000, 4 months.

"Functional Imaging of Brain Areas Involved in Ambient Vision," Dr. Peter Fox, Veridian, $9,340, 1 year.

"Mechanical Properties of Glass Ionomer Cements," Dr. Franklin Garcia-Godoy, GC America, NIH/NIDCR, $1,000, 1 year.

"Changes in Surface Hardness of Conventional and Resin Modified Glass Ionomer Cements," Dr. Franklin Garcia-Godoy, Academy of Operative Dentistry, $2,200, 3 months.

"Radiopaque Adhesive and Restorative Resins," Dr. Henry Rawls, Research Foundation of State University of New York/NIH, $72,894, 1 year.

"South Texas Injury Control and Research Center," Dr. Roberto Villarreal, University Health System, $206,397, 1 year.

Ethics in Health Lectureship given

Dr. Fox is the Annenberg Professor Emerita of the Social Sciences at The University of Pennsylvania, and has taught and studied medical sociology and bioethics for more than 40 years. She received her Ph.D. in sociology from Harvard in 1954, and went on to write seven books and numerous articles.

The well-attended lecture began with a discussion of coping methods that medical students have used to overcome medical uncertainties. These methods include intellectualization, detachment and "gallows" humor. Dr. Fox then discussed the new forms of uncertainty that have emerged since the 1980s. These include the relationship between medicine and molecules; the emergence and re-emergence of infectious diseases; the increasing importance of prognosis; the "irony of iatrogenics," in which medical treat-ments for disease can do as much harm as the disease itself; and vocational, epistemological and bioethical uncertainty.

She closed with an appeal for medical educators to help their young students learn to cope with some of the difficulties they will encounter during their careers.

The lecture was given under the auspices of the Health Science Center's Center for Ethics and the Humanities in Health Care, and is made possible by the Hans and Charlotte Salinger Endowment, which supports teaching about the non-technical, humanistic side of patient care.

Science '99 scheduled for Oct. 28

Science '99 "Explore the Connections" will include exhibits from occupational therapy, clinical laboratory sciences, respiratory care and the South Texas Poison Center, among others. Students participating will receive information on careers and the Health Science Center's various schools.

The expo will begin at 8:30 a.m. with a registration and welcome session. Exhibits for Session I will run from 9 to 11:30 a.m. Session II will run from 12:30 to 3:30 p.m.

The Office of Special Programs is looking for faculty and staff to help at the registration tables and escort students to breakout sessions. Additional exhibitors also are welcome.

For more information, to register or reserve a table, contact the Office of Special Programs at ext. 2654.

SPORE grant boosts cancer research

The project, funded through a Specialized Program of Research Excellence (SPORE) grant from the NCI, will be a collaborative effort between the Health Science Center, The University of Texas M. D. Anderson Cancer Center in Houston, The University of California at San Francisco, Northwestern University in Chicago, The University of Pittsburgh and Baylor College of Medicine in Houston.

The SPORE grant supports innovative, short-term research collaborations expected to have immediate impacts on cancer care. First-year funding for the ovarian cancer treatment program is $1.9 million.

Patent smiles

Of Note

Breast cancer caregiver conference Oct. 23

The conference, "Caring for the Caregiver," is a collaborative effort between the Susan G. Komen Breast Cancer Foundation and 17 area agencies and businesses. The event is designed to focus on the needs of family members and friends of breast cancer patients and will include topics such as issues in the workplace, fatigue and stress management. Attendees also may experience the latest in interactive computer technology with "In My Steps," a virtual reality simulator that replicates the debilitating effects of cancer-related anemia and fatigue.

The conference itself is free. Lunch is $15. For more information, call the foundation at 222-9009.

Red Ribbon campaign supports drug-free life

The campaign began in 1985 to remind people to moderate their use or abstain from alcohol, tobacco and recreational drugs. Students will be provided red ribbons during the week.

Annual greeting card contest begins

The winner's artwork will be placed on the holiday greeting card that the dean's office sends around the nation. The winner also will receive a $100 savings bond and will be acknowledged inside the greeting card.

Artwork entered in the contest should be on plain white paper (8 1/2 x 11) and should not have any religious connection. It should include the child's name, age and relationship to the Dental School.

Entries will be taken by Norma Valdez in the dean's office no later than Oct. 29.

Annual Hollers Lecture set for Oct. 29

For more information or to register, call the Office of Continuing Dental Education (CDE) at ext. 3177.

The Hollers Memorial Lectureship pays tribute to the leadership and achievements of Dr. James P. Hollers (1899-1976). He was one of San Antonio's leading citizens, played an active role in the development of the Dental School, and served as president of the American Dental Association and other organizations.

Dentists who attended at least 100 hours of CDE courses at the Health Science Center between Sept. 1, 1998, and Aug. 31, 1999, will be honored at the Hollers Lectureship with the Kenneth D. Rudd Continuing Dental Education Participant Award.

Reservations due Nov. 8 for P. I. Nixon dinner

Dr. Kerr will discuss "Historic Advocates for the Public Health of Children." An amateur historian who teaches courses in the history of public health, Dr. Kerr has conducted extensive studies of children in both developed and underdeveloped countries with the objective of identifying the preventable causes of fetal, infant, and childhood death in Texas.

Reservations for the event must be made by Nov. 8 through Special Collections Library Assistant Pat Brown at ext. 2400.

Early voting sites open through Oct. 29

Voting places will be set up in major malls (except North Star Mall) and at locations throughout the city. Hours are 8 a.m. to 6 p.m. Monday through Friday, 10 a.m. to 6 p.m. Saturday, and noon to 6 p.m. on Sunday.

For more information, call Bexar County Voter Registration at 335-6625.

The following sites are designated early voting areas:

• Bexar County Justice Center, 300 Dolorosa

• Central Park Mall, 622 N.W. Loop 410

• Claude Black Center, 2805 E. Commerce St.

• Crossroads Mall, 4522 Fredericksburg Road

• Dellcrest Shopping Center, 1800 S. W.W. White Road

• Handy Andy Supermarket, 4010 W. Commerce St.

• Handy Andy Supermarket, 2801 Nogalitos St.

• Handy Andy Supermarket, 910 Bandera Road

• Handy Andy Supermarket, 8353 Culebra Road

• H-E-B Central Market, 4821 Broadway

• H-E-B #1, 1955 Nacogdoches Road

• H-E-B #8, 300 W. Olmos Drive

• H-E-B #11, 400 Valley Hi Drive

• H-E-B #20, 2929 Thousand Oaks Drive

• H-E-B #21, 3323 S.E. Military Drive

• Ingram Park Mall, 6301 N.W. Loop 410

• Kmart, 7723 Gilbeau Road

• McCreless Mall, 4100 S. New Braunfels Ave.

• Rolling Oaks Mall, 6909 N. Loop 1604 E.

• St. Phillip's College (southwest campus), 800 Quintana Road

• Somerset Conference Center, 19644 Somerset Road

• South Park Mall, 2310 S.W. Military Drive

• Universal City Hall, 2150 Universal City Blvd.

• Wal Mart, 910 S.E. Military Drive

• Wal Mart, U.S. 281 and Loop 1604 N.E.

• Wal Mart, 5555 De Zavala Road

• Westlakes Mall, 1401 S. W. Loop 410

• Windsor Park Mall, 7900 Interstate 35 North

Applause

Calendar for Oct. 25 - 31

Tuesday, October 26
6:30 a.m.
Podiatry Case Conf. (LEC: 2.010)
8:00 a.m.
Medical Housestaff Specialty Conf. "Diabetes Management," Dr. Pugh (MED: 409L)
8:00 a.m.
Otolaryngology-Head & Neck Surgery Grand Rounds "Dizziness," Dr. Bernard Palmer (MED: 444B)
8:00 a.m.
Rehab Medicine Lecture Series "Shoes & Shoe Inserts," Dr. Thomas Darm (UH: Reeves Rehab Center 3rd-floor classroom)
8:30 a.m.
Training Office "Putting Together a Job Manual" (call ext. 2320 to register)
11:30 a.m.
Burroughs Wellcome Foundation Lecture "Aspartate Transcarbamylase: the Hemoglobin of Enzymology," Dr. Howard Schachman, University of California at Berkeley (MED: 409L)
Noon
TNT "Cytology: The Interpretation of FNA, Prepared by ThinPrep Technique," Dr. Claire Michael, University of Michigan, Ann Arbor, MI (call ext. 2700 for information)
1:15 p.m.
Psychiatry Grand Rounds "Constructive Views of Disorder & Human Development," Dr. Michael Mahoney, University of North Texas (MED: 409L)
1:30 p.m.
TNT "Laboratory Technology Issues: Hematopathology: A Case Study Approach," Bernadette Rodak, Indiana University, Indianapolis, IN (call ext. 2700 for information)
4:00 p.m.
Molecular Medicine Seminar Series "Novel Roles of Topoisomerases in Tumor Cell Apoptosis," Dr. Leroy Liu, Robert Wood Johnson Medical School (IBT: 3.002)

Wednesday, October 27
6:30 a.m.
Podiatry Grand Rounds (MED: 309L)
7:00 a.m.
Vascular Surgery Grand Rounds, Dr. Mellick Sykes (MED: 209L)
8:00 a.m.
Medical Grand Rounds "Update on the Neurological Manifestations of Antiphospholipid Antibody Syndrome," Dr. Robin Brey (MED: 409L)
9:00 a.m.
Surgery Trauma M&M Conf., Dr. Ronald Stewart (MED: 309L)
Noon
TNT "Women's Health Issues & Trends: Estrogen & Brain Function: State of the Art & Perspectives," Dr. Ann Morrison, Alzheimer's Disease Research Center, Baltimore, Md. (call ext. 2700 for information)
1:00 p.m.
Training Office "Advanced Travel Procedures" (call ext. 2320 to register)
1:30 p.m.
TNT "Health Care Commentaries: JCAHO Requirements of Measurement Systems," Dr. Barbara Covington, Healthcare Consultants, Crocker, MO. (call ext. 2700 for information)
3:30 p.m.
Burroughs Wellcome Foundation Lecture "Science Policy & Its Impact on Research," Dr. Howard Schachman, University of California at Berkeley (LEC: 3.104A)

Thursday, October 28
7:30 a.m.
Thoracic Surgery Resident Teaching Conf. (VA: 4th-floor CT Library A404)
7:30 a.m.
Obstetrics & Gynecology Grand Rounds "Preterm Labor & Infection," Dr. Susan Cox (MED: 309L)
Noon
Pulmonary, Thoracic & Oncology Conf. (MED: 309L)
4:00 p.m.
Surgery Tumor Conference, Dr. Anatolio Cruz (MED: 209L)
4:00 p.m.
Anesthesiology Grand Rounds "Intrathecal Narcotics for Labor," Dr. Kelly Knape (UH: 212)
4:30 p.m.
Citywide Thoracic Grand Rounds Conf. "Case Presentations," Dr. Joseph Atiya (MED: 309L)

Friday, October 29
7:30 a.m.
Pediatric Grand Rounds "Pediatric Cardiac Intervention: The Non-Surgical Treatment of Congenital Heart Disease," Dr. Makram Ebeid, University of Mississippi Medical Center (MED: 409L)
8:00 a.m.
Medical Housestaff Specialty Conf. "The Dizzy Patient," Dr. Graffin (LEC: 3.102B)
8:00 a.m.
Rehab Medicine Lecture Series "Normal Gait," Dr. Andrew Gitter (UH: Reeves Rehab Center 3rd-floor classroom)
8:30 a.m.
Continuing Dental Education "James P. Hollers Memorial Lectureship: Great Communication Equals Great Production," Cathy Jameson (call ext. 3177 for information)