Exceptional Responders Pilot study: Molecular profiling of tumors from cancer patients who have had an exceptional response to treatment.
I. To identify molecular indicators in malignant tissues from patients who were exceptional responders on clinical trials or treatments using whole exome and/or targeted deep sequencing as well as potentially other sequencing, and other molecular characterization methods (if adequate tissue exists).
II. To explore associations between the identified molecular indicators and the putative mechanism of action of the treatment received by the patient.
III. To test the feasibility of identifying exceptional responders, obtaining the relevant tumor and normal tissue and clinical data, and performing whole exome and/or targeted deep sequencing on these samples.
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