A Phase 0, Investigator Initiated Study, Evaluating the Impact of Omega 3 Free Fatty Acid Supplementation on Aromatase in Obese Postmenopausal Women with Estrogen Receptor Positive Breast Cancer (CTMS# 15-2100)
Assess the impact of dietary (omega 3 FFA) or pharmacological (ASA) COX-2 inhibitors on:
patient serum-induced expression of PGE2 and aromatase by neoplastic mammary epithelial cells
circulating levels of pro-inflammatory cytokines (i.e. IL-6, TNF-¿, IGF-1), steroids (i.e. estrogen and testosterone) and lipids (omega-6 and omega-3 PUFAs)
Correlation for body mass index impact on response to COX2 inhibition.