MATCH Treatment Subprotocol R: Phase II Study of Trametinib in Patients with BRAF Fusions, or with V600E, nonV600K BRAF Mutations (CTMS# 15-2084)
To evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers/lymphomas.
To evaluate the proportion of patients alive and progression free at 6 months of treatment with targeted study agent in patients with advanced refractory cancers/lymphomas.
To evaluate time until death or disease progression.
To identify potential predictive biomarkers beyond the genomic alteration by which treatment is assigned or resistance mechanisms using additional genomic, RNA and protein-based assessment platforms.