The Health Science Center, in partnership with the Cancer Therapy and Research Center (CTRC), created the San Antonio Cancer Institute (SACI), one of the two National Cancer Institute-designated Cancer Centers in Texas.

UTHSCSA faculty treat patients in dozens of affiliated institutions, including adjacent teaching hospitals University Hospital and the Audie Murphy Division, South Texas Veterans Health Care System. Major clinical activity also occurs at CHRISTUS Santa Rosa Children's Hospital and the other CHRISTUS locations.

University faculty practice as part of the University Physicians Group. A major new Medical Arts Research Center will enhance future clinical care.

The Health Science Center is part of the Southwest Research Consortium, made up of nine San Antonio institutions that encourage joint projects, sharing of research facilities and adjunct faculty appointments. The eight other members of the Consortium are: The University of Texas at San Antonio, Brooke Army Medical Center, Trinity University, Brooks Air Force Base Human Systems Center Armstrong Laboratory, Wilford Hall Medical Center (USAF), the Southwest Research Institute and the Southwest Foundation for Biomedical Research.

The Health Science Center's outreach extends well beyond its six campuses. UTHSCSA has affiliations and partnerships with health-education and patient-care programs throughout South Texas, including the Lower Rio Grande Valley.