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Programs
Department
Kenneth M. Hargreaves, D.D.S., Ph.D.
Professor and Chair
Dr. Hargreaves received his B.A. in neurobiology from the University of California at Berkeley in 1977, his D.D.S. from Georgetown University in Washington, D.C., in 1983, and his Ph.D. in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in 1986.
From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently professor and chair of the Department of Endodontics, and professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at UT Health San Antonio. He also maintains a private practice limited to endodontics.
Research Interests: Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics, regenerative endodontics, clinical and translational research
Primary research interests are in the areas of pain and inflammation. His research team has published more than two hundred papers that have generated more than 15,000 life-time citations. He has also edited two textbooks, Seltzer and Benders Dental Pulp, and Cohen’s Pathways of the Pulp. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic and other pain patients, as well as the clinical outcomes of non-surgical endodontic procedures.
Expertise: Endodontic diagnosis, prognosis, treatment, Mechanisms of Apical Periodontitis
Publications
Book/Monograph |
| Hargreaves KM, Berman L. Cohen?s Pathways of the Pulp, 11th edition St. Louis: Elsevier; 2016. |
Journal Article |
| Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian AN, Hargreaves KM. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury Molecular Pain 2016 Jan;12. |
| Eskander M, Ruparel S, Green D, Por E, Chen P, Jeske NA, Gao X, Flores E, Hargreaves KM. Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms Journal of Neuroscience 2015 Jun;35(22):8593-8603. |
| Dissanayaka WL, Zhu L, Hargreaves KM, Jin L, Zhang C. In Vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells Journal of Endodontics 2015 Jan;41:663-670. |
| Fehrenbacher J, Bingener J, Aho J, Wasky P, Locke E, Schwesinger W, Van Sickle K, Hargreaves KM. Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study Chirungia 2015 Jan;. |
| Gonzales CB, Kirma NB, De La Chapa J, Chen R, Henry MA, Luo S, Hargreaves KM. Vanilloids induce oral cancer apoptosis independent of TRPV1 interactions Oral Oncology 2014 May;50(5):437-447. |
Not Specified |
| Dissanayaka WL, Hargreaves KM, Jin L, Samaranayake L, Zhang C. The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo Tissue Eng Part A 2015 Jan;21:550-563. |
Grants
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Federal |
|
| Funding Agency | NIDR |
| Title | Oral Surgery & Initiation of Neurogenic Inflammation |
| Status | Complete |
| Period | - Present |
| Role | Co-Principal Investigator |
| Grant Detail | |
| Funding Agency | Department of Defense |
| Title | Developing Novel Analgesics for Treating Burn Pain |
| Status | Active |
| Period | 1/2015 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | Test novel analgesic regimes targeting TRPV1 in a murine burn model |
Private |
|
| Funding Agency | USAA Foundation |
| Title | New Method to Treat Burn Pain in Our Wounded Warriors |
| Status | Active |
| Period | 6/2010 - 1/2029 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Barker Foundation |
| Title | Pain Management |
| Status | Active |
| Period | 1/2013 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | American Association for Endodontists Foundation |
| Title | Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots |
| Status | Active |
| Period | 1/2013 - 1/2019 |
| Role | Principal Investigator |
| Grant Detail | PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves. This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics. |
Education
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| Year | Degree | Discipline | Institution |
| 1993 | Postdoctoral Training | Endodontics | University of Minnesota, School of Dentistry Minneapolis , MN |
| 1990 | Postdoctoral Fellowship | Sr Staff Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1988 | Postdoctoral Fellowship | Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1986 | PhD | Physiology | Uniformed Services University of the Health Sciences Bethesda , MD |
| 1985 | Postdoctoral Fellowship | NRSA Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1983 | DDS | Dentistry | Georgetown University Washington , DC |
| 1981 | Internship | Research Assistant, Pharmacology | Georgetown University Washington , DC |
| 1980 | Internship | Predoc Research Fellow, School of Dentistry | Georgetown University Washington , DC |
| 1977 | BA | Neurobiology | University of California at Berkeley Berkeley , CA |