Contact
Programs
Department
Currently seeking M.S. & Ph.D. studentsYidong Bai, Ph.D.
Professor
Dr. Yidong Bai's lab is interested in a comprehensive understanding of mitochondrial function at the molecular, cellular, tissue, and animal levels. Mitochondria play a central role in cellular energy and also regulate apoptosis, signal transduction and cell growth. Mitochondrial defects have been reported in a wide range of conditions, such as diabetes, neurodegenerative diseases, cancers, and aging.
The central theme in the laboratory is to investigate the regulatory mechanisms working in mitochondria and the role of mitochondria in regulating various cellular pathways.
In particular, the lab is interested in the dynamics of the machinery for oxidative phosphorylation, the role of mitochondrial dysfunction in human diseases including cancer and aging process. Various approaches are also explored in restoring the mitochondrial function in cells with mitochondrial deficiency.
Publications
Abstract |
| Bai Y. BHRF1 enhances EBV mediated NPC tumorigenesis; 2019 May. (IIMS/CTSA 10th Annual Frontiers of Transnational Science Research Day). |
| Souza L., and Bai Y. Doxorubicin Treatment Drives Nd5 Gene Heteroplasmy Toward Mutant Genotype in Mouse Cybrids Cell Lines; 2018 Sep. (The Environmental Mutagenesis and Genomics Society). |
| Bai Y. Quality control of respiratory machinery; 2015 Nov. (12th Annual Meeting of Asia Society Mitochondrial Research and Medicine. Nov. 14-16, 2015, Hangzhou). |
| Bai Y. Protein Acetylation and Metabolism; 2015 Nov. (International Symposium on Mitochondrial Biology and Medicine (ISMBM 2015), Xi`an, China). |
| Bai Y. Alterations in metabolic profiling of Leber`s Hereditary Optic Neuropathy; 2015 Oct. (2015 Nathan Shock Center Conference on Aging). |
| Bai Y. The role of ND4, ND5 and ND6 in complex I assembly; 2015 Jun. (Gordon Research Conference, Bioenergetics, June 22-26, 2015. Andover, New Hampshire). |
| Bai Y. The implication of mitochondrial DNA mutations and dysfunction in colorectal cancer; 2014 Oct. (China-US biomedical symposium on oncology). |
| Idowu A, Olatunji-Bello I, Bai Y. The improvement of neuronal function in normal aging by melatonin is mediated by altering mitochondria bioenergetics; 2014 May. (The FASEB Journal). |
Journal Article |
| Li, B., Liang, F., Ding, X., Yan, Q., Zhao, Y., Zhang, X., Bai, Y., Huang, T., and Xu, B. Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating mitochondrial dynamics Behavioral Brain Research 2019 Dec;376. |
| Lyu L, Wang Q, Song S, Li L, Zhou H, Li M, Jiang Z, Zhou C, Chen G, Lyu J, Bai Y. Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients Mitochondrion 2019 Jan;45:1-6. |
| Sharma, LK, Tiwari, M., Rai, NK, and Bai, Y. Mitophagy activation repairs Leber?s Hereditary Optic Neuropathy associated mitochondrial dysfunction and improves cell survival Human Molecular Genetics 2019 Jan;28:422-433. |
| Song S, Gong S, Singh P, Lyu J, Bai Y. The interaction between mitochondria and oncoviruses Biochim Biophys Acta Mol Basis Dis 2018 Jan;1864:481-487. |
| Cunningham GM, Flores LC, Roman MG, Cheng C, Dube S, Allen C, Valentine JM, Hubbard GB, Bai Y. Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice Geroscience 2018 Jan;40:453-468. |
| Lyu L, Wang Q, Song S, Zhou H, Li M, Zhou C, Jiang Z, Li L, Lyu J, Chen G, Bai Y. Dataset of mitochondrial genome variants in oncocytic tumors Data Brief 2018 Jan;17:1149-1152. |
| Li H, Shen L, Hu P, Huang R, Cao Y, Deng J, Yuan W, Liu D, Yang J, Gu H, and Bai Y. Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions Biochim Biophys Acta Mol Basis Dis 2017 Jan;1863:2266-2273. |
| Chen H, Bai J, Dong F, Fang H, Zhang Y, Meng W, Liu B, Luo Y, Liu M, Bai Y, Abdul-Ghani MA, Li R, Wu J, Zeng R, Zhou Z, Dong LQ, Liu F. Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance FASEB J 2017 Jan;31(6):2314-2326. |
| Etzler JC, Bollo M, Holstein D, Deng JJ, Perez V, Lin DT, Richardson A, Bai Y, Lechleiter JD. Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation Arch Biochem Biophys 2017 Jan;613:61-68. |
| Nie, H., He, J., Zhang, F., Li, M., Wang, Q., Lu, J., and Bai, Y. Mitochondrial common deletion is elevated in blood of breast cancer patients under oxidative stress Mitochondrion 2016 Jan;26:104-112. |
| Jiang, PP, Liang, M., Zhang, C., Zhao, X., He, Q., Cui, C., Liu, X., Sun, YH, Fu, Q., Ji, Y., Bai, Y., Huang,T., and Guan, MX. Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber?s hereditary optic neuropathy-associated mitochondrial DNA mutation Human Molecular Genetics 2016 Jan;25(16):3613-3625. |
| Mishur, RJ, Khan, M., Munkacsy, E., Sharma, L., Bokov, A., Beam, H., Radetskaya, O., Borror, M., Lane, R., Bai, Y., and Rea, S. Mitochondrial Metabolites Extend Lifespan Aging Cell 2016 Jan;. |
| Zhang, F., Fang, H., Li, F., Shen, L., Du, D., Qiu, R., Shi, H., Ma, L., Nie, H., Bai, Y. and Lyu, J. Mitochondrial DNA haplogroups modify the risk of osteoarthritis by altering mitochondrial biogenesis and intracellular mitochondrial signals Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016 Jan;. |
| Fang H, Shi H, Li X, Sun D, Li F, Li B, Ding Y, Ma Y, Liu Y, Zhang Y, Shen L, Bai Y, Yang Y, Lu J. Exercise intolerance and developmental delay associated with a novel mitochondrial ND5 mutation Sci Rep 2015 May;5:10480-10480. |
| Vartak, R., Deng, J., Fang, H., and Bai, Y. Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015 Jan;1852:1531-1539. |
| Porras CA, Bai Y. Respiratory supercomplexes: plasticity and implications Front Biosci (Landmark Ed) 2015 Jan;20:621-634. |
| Liu J, Wang L, Guo X, Pang Q, Wu S, Wu C, Xu P, Bai Y. The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis PLoS One 2014 Sep;9(9):108394-108394. |
| Vartak RS, Semwal MK, Bai Y. An update on complex I assembly: the assembly of players J Bioenerg Biomembr 2014 Aug;46(4):323-328. |
| Li X, Zhao K, Guo W, Liu X, Liu J, Gao J, Chen Q, Bai Y. A novel manganese complex LMnAc selectively kills cancer cells by induction of ROS-triggered and mitochondrial-mediated cell death Sci China Life Sci 2014 Jun;. |
| Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy Autophagy 2014 Jun;10(6):1054-1070. |
| Wu S, Duan C, Zhang F, Mckenzie R, Zheng J, Dennis B, Farooq U, Bai Y, Guo X. Difference in apoptosis associated genes expression profiling and immunohistology analysis between Kashin-Beck disease and primary osteoarthritis Chinese Science Bulletin 2014 Mar;59(9):833-839. |
| Wu S, Wang W, Wu C, Zhang F, Dennis B, Qu C, Bai, Y Guo X. Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis Gene 2014 Jan;535:124-130. |
| Nie H, Shu H, Vartak R, Milstein A, Mo Y, Hu X, Fang H, Shen L, Ding Z, Lu J, Bai Y. Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: A meta-analysis of 38 studies PLoS ONE 2013 Jan;8(7):e67953-e67953. |
| Liu JT, Guo X, Ma WJ, Zhang YG, Xu P, Yao JF, Bai YD, Bai Y. Mitochondrial Function Is Altered in Articular Chondrocytes of an Endemic Osteoarthritis, Kashin-Beck Disease Osteoarthritis Cartilage 2010 Jul;. |
| Bayona-Bafaluy MP, Acin-Perez R, Mullikin JC, Park JS, Moreno-Loshuertos R, Hu P, Perez-Martos A, Fernandez-Silva P, Bai Y, Enriquez JA. Revisiting the mouse mitochondrial DNA sequence Nucleic Acids Res 2003 Sep;31(18):5349-5355. |
| Bai Y, Hajek P, Chomyn E, Chan BB, Seo A, Matsuno-Yagi T, Yigi T, Attardi G. Lack of Complex I Activity in Human Cells Carrying a Mutation in MtDNA-Encoded ND4 Subunit is Corrected by the Saccharomyces cerevisiae NADH-Quinone Oxidoreductase (NDI1) Gene J Biol Chem 2001 Sep;276:38808-38813. |
| Shakeley RM, Attardi G, Bai Y,. Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria revealed Mol Cell Biol 2000 Jan;20:805-815. |
| Bai Y, Lee D, Chasin A. Control of 3?Splice Site choices in vivo by ASF/SF2 and hnRNP A1 Nuclear Acid Research 1999 Apr;27:1126-1134. |
| Bai Y, Attardi G. The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme EMBO J 1998 May;17:4848-4858. |
| Zhang, J., Huang, J., Xu, D., Sheng. Z., Bai, Y., and Wu, J. Identification of Two New Species of Halobacterium Journal of Fudan University (Natural Science) 1989 Dec;28:56-62. |
Review Article |
| Li F., Shen L., Fang H., and Bai Y. Mitochondrial Respiratory Complex I Chinese Journal of Cell Biology 2014 Jan;36:1153-1161. |
Grants
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Federal |
|
| Funding Agency | NIH |
| Title | Epigenetics of energy homeostasis, bioenergetics and obesity |
| Status | Active |
| Period | 9/2018 - 8/2023 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH |
| Title | The role of Grp75 in supercomplex assembly and neurodegeneration |
| Status | Active |
| Period | 9/2018 - 8/2020 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIGMS |
| Title | Regulation of Mitochondrial Respiratory Complex I Dynamics |
| Status | Active |
| Period | 8/2014 - 5/2020 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH |
| Title | MECHANISMS BY WHICH CU/ZNSOD OVEREXPRESSION IMPROVES METABOLIC HEALTH IN RATS |
| Status | Active |
| Period | 9/2018 - 8/2019 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIDDK |
| Title | Regulation and Function of Adiponectin Oligomerization |
| Status | Active |
| Period | 4/2014 - 3/2018 |
| Role | Co-Investigator |
| Grant Detail | Co-investigator of a NIH grant with Dr. Feng Liu as the PI. |
Private |
|
| Funding Agency | Owens Medical Research Foundation |
| Title | The regulation of mitochondrial DNA heteroplasmy in tumorigenesis |
| Status | Active |
| Period | 1/2016 - 12/2020 |
| Role | Principal Investigator |
| Grant Detail | |
State |
|
| Funding Agency | NIH/National Center for Advancing Translational Sciences |
| Title | HCC and Health Disparity |
| Status | Active |
| Period | 9/2019 - 8/2020 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Office for Research LSOM |
| Title | Enhancement of Sustainable Research |
| Status | Complete |
| Period | 6/2018 - 5/2019 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Depts of Medicine and CSA， UTHSCSA |
| Title | The role Cardiolipin in Mitochondrial DNA alterations mediated late-onset Dox toxicity |
| Status | Active |
| Period | 2/2018 - 1/2019 |
| Role | Co-Principal Investigator |
| Grant Detail | |
| Funding Agency | HSC-Barshop Institute |
| Title | Mitigating Ageing by Shifting Mitochondrial DNA heteroplasmy |
| Status | Active |
| Period | 7/2017 - 6/2018 |
| Role | Principal Investigator |
| Grant Detail | A pilot grant a NIH P30 center grant at Nathan Shock Center. |
| Funding Agency | HSC-CBN PILOT PROJECTS |
| Title | GENERATION AND CHARACTERIZATION OF A RETINAL GANGLION CELL MODEL FOR LEBER'S HEREDITARY OPTIC NEUROPATHY |
| Status | Active |
| Period | 1/2017 - 12/2017 |
| Role | Principal Investigator |
| Grant Detail | |
Education
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| Year | Degree | Discipline | Institution |
| 1996 | PhD | Biological Sciences (mentor: Larry Chasin) | Columbia University New York , NY |
| 1992 | MS | Biological Sciences | Columbia University New York , NY |
| 1991 | MA | Biological Sciences | Columbia University New York , NY |
| 1985 | BA | Microbiology | Fudan University Shanghai , China |
| Postdoctoral Training | Molecular Genetics (mentor: Giuseppe Attardi) | California Institute of Technology Pasadena , CA |