Robert Brenner, Ph.D.
The focus of Dr. Robert Brenner's lab has been to understand how ion channels regulate excitability of cells. Our approach is to use electrophysiology and biophysical techniques to understand channel regulation in vitro, and complement these studies by generating mouse models to understand the physiological consequences of ion channel regulation.
Currently, our lab is investigating the role of the large conductance calcium- and voltage-activated potassium channel and their accessory beta subunits in regulating excitability in hippocampal neurons (brain slice preparation, calcium measurements, and EEG recordings) and in airway smooth muscle (muscle constriction studies and electrophysiology).
We have made major contributions to understanding this ion channel, from early characterization of the Drosophila gene where it was first cloned, to initial cloning and characterization of the accessory subunits, to gene knockout of accessory beta1 and beta4 subunits in mice. The biophysical studies in our lab have provided new incite into how beta subunits modulate BK channel gating. Recent contributions from our lab include findings that BK potassium channel gain-of-function enhance excitability in some neurons to promote seizures and epilepsy.
We are currently studying how BK channels are regulated by functional coupling with colocalized calcium sources in dentate gyrus granule neurons and airway smooth muscle.
|Cross DJ, Jetter GM, Mayes BN, Morgan LC, Szabo CA, Brenner R, Cavazos JE. Interictal high frequency oscillations in temporal lobe epilepsy might predict the location of seizure onset zone; 2008 Jan. (Epilepsia (American Epilepsy Society Meeting)).
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||University of Texas at Austin
Austin , TX
||San Diego State University
San Diego , CA
||University of Texas at Arlington
Arlington , TX
||Stanford University School of Medicine
Stanford , CA