Charles Patrick France, Ph.D.
Professor, Pharmacology
Research in Dr. Charles France's lab focuses on interactions between behavior and pharmacology and how those interactions impact the abuse liability of drugs.
The lab's major goal is to understand how the subjective and other abuse-related effects of drugs change as a consequence of particular behavioral and pharmacologic histories. Behavioral procedures developed in this laboratory permit systemic investigation of drug dependence and withdrawal and ongoing studies examine how these phenomena can be modified by behavioral and pharmacologic interventions.
Publications
Abstract |
| Serafine KM, France CP. Characterization of the discriminative stimulus effects of lorcaserin in rats; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| George CM, Owens WA, France CP, Toney GM, Daws LC. Anorexia increases sensitivity to cocaine-induced locomotion: evidence for dysregulation of dopamine transporters; 2016 Jan. (Presented at the Society for Neuroscience Annual Meeting). |
| Gerak LR, Collins GT, France CP. Effects of lorcaserin on cocaine and methamphetamine self-administration and on reinstatement of extinguished responding in rhesus monkeys; 2016 Jan. (Presented at the College of Problems of Drug Dependence Annual Meeting). |
| Weed PF, Gerak LR, Maguire DR, France CP. Controlling for individual differences in temperature sensitivity reduces potency differences among subjects in a warm water tail withdrawal procedure in rhesus monkeys; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| Minervini V, France CP. Behavioral characterization of spiradoline and CP55,940 in rats: potential of drug mixtures for treating pain; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| Collins GT, France CP. Effects of intermittent or ad libitum consumption of high-fat diet on the reinforcing effects of cocaine in male rats; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| Maguire DR, France CP. Amphetamine enhances impulsive behavior in rats responding under a stop signal procedure; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| Labay C, Serafine K, France CP. Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine; 2016 Jan. (Presented at the Experimental Biology Annual Meeting). |
| Gerak LR, France CP. Combined treatment with morphine and Delta9-tetrahydrocannabinol in rhesus monkeys: antinociceptive effects, tolerance and withdrawal; 2015 Jan. (Presented at Experimental Biology). |
| Collins GT, Rice KC, France CP. Discriminative stimulus effects of drug mixtures: studies with cocaine, MDPV, and caffeine; 2015 Jan. (Presented at the American College of Neuropsychopharmacology). |
| Collins GT, Gerak LR, France CP. Lorcaserin (Belviq(R)) reduces the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys; 2015 Jan. (Presented at Experimental Biology). |
| Serafine KM, France CP. Characterization of the behavioral effects of lorcaserin in rats; 2015 Jan. (Presented at Experimental Biology). |
| Maguire DR, France CP. Effects of daily morphine treatment on impulsivity in rats responding under a 5-choice serial reaction time task; 2015 Jan. (Presented at Experimental Biology). |
Book Chapter |
| Czoty PW, Banks ML, Nader MA, France CP. Nonhuman primate self-administration in assessments of abuse potential. In: CG Markgraf, TJ Hudzik & DR Compton (Eds). Nonclinical Assessment of Abuse Potential for New Pharmaceuticals. London: Elsevier; 2015. p. 81-99. |
Editorial |
| France CP. Effects of opiates The International Journal of Neuropsychopharmacology 2014 Jan;17. |
Journal Article |
| Minervini V, Dahal S, France CP. Behavioral characterization of kappa opioid receptor agonist spiradoline/cannabinoid receptor agonist CP55940 mixture in rats Journal of Pharmacology and Experimental Therapeutics 2017 Jan;360:280-287. |
| Weed PF, France CP, Gerak LR. Preference for an opioid/benzodiazepine mixture over an opioid alone using a concurrent choice procedure in rhesus monkeys J Pharmacol Exp Ther 2017 Jan;362:59-66. |
| Collins GT, Abbott M, Galindo K, Rush EL, Rice KC, France CP. Discriminative stimulus effects of binary drug mixtures: studies with cocaine, MDPV and caffeine J Pharmacol Exp Ther 2016 Oct;359(1):1-10. |
| Serafine KM, Rice KC, France CP. Characterization of the discriminative stimulus effects of lorcaserin in rats J Exp Anal Behav 2016 Sep;106(2):107-116. |
| Serafine KM, Labay C, France CP. Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats Drug Alcohol Depend 2016 Aug;165:45-52. |
| Gerak LR, France CP. Combined treatment with morphine and Delta9-tetrahydrocannabinol in rhesus monkeys: antinociceptive tolerance and withdrawal J Pharmacol Exp Ther 2016 May;357(2):357-366. |
| Maguire DR, Henson C, France CP. Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task British Journal of Pharmacology 2016 Apr;173(8):1350-1362. |
| Maguire DR, France CP. Effects of daily delta-9-tetrahydrocannabinol treatment on heroin self-administration in rhesus monkeys Behavioural Pharmacology 2016 Jan;27:249-257. |
| Gerak LR, France CP. Combined treatment with morphine and Delta9-tetrahydrocannabinol (THC) in rhesus monkeys: antinociceptive tolerance and withdrawal J Pharmacol Exp Ther 2016 Jan;357:357-366. |
| Lamb RJ, Maguire, David R, Ginsburg BC, Pinkston, Jonathan W, France CP. Determinants of choice, and vulnerability and recovery in addiction Behav Processes 2016 Jan;127:35-43. |
| Gerak LR, Collins GT, France CP. Effects of lorcaserin on cocaine and methamphetamine self-administration and reinstatement of responding previously maintained by cocaine in rhesus monkeys Journal of Pharmacology and Experimental Therapeutics 2016 Jan;359:383-391. |
| Maguire DR, Gerak LR, France CP. Delay discounting of the mu opioid receptor agonist remifentanil in rhesus monkeys Behav Pharmacol 2016 Jan;27:148-154. |
| Maguire DR, France CP. Interactions between cannabinoid receptor agonists and mu opioid receptor agonists in rhesus monkeys discriminating fentanyl Eur J Pharmacol 2016 Jan;784:199-206. |
| Collins GT, Gerak LR, Javors MA, France CP. Lorcaserin reduces the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys J Pharmacol Exp Ther 2016 Jan;356:85-95. |
| Maguire DR, France CP. Additive antinociceptive effects of mixtures of the kappa opioid receptor agonist spiradoline and the cannabinoid receptor agonist CP55940 in rats Behavioural Pharmacology 2016 Jan;27(1):69-72. |
| Maguire DR, Gerak LR, France CP. Effect of daily morphine administration and its discontinuation on delay discounting of food in rhesus monkeys Behav Pharmacol 2016 Jan;27:155-164. |
| Serafine KM, Bentley TA, Kilborn DJ, Koek W, France CP. Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning European Journal of Pharmacology 2015 Oct;764:529-536. |
| Collins GT, Chen Y, Tschumi C, Rush EL, Mensah A, Koek W, France CP. Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57Bl/6J mice Experimental and Clinical Psychopharmacology 2015 Aug;23:228-237. |
| Baladi MG, Horton RE, Owens BS, Daws LC, France CP. Eating high fat chow decreases dopamine clearance in adolescent and adult male rats, but selectively enhances the locomotor stimulating effects of cocaine in adolescents The International Journal of Neuropsychopharmacology 2015 Jan;18. |
| Serafine KM, Rice KC, France CP. Directly observable behavioral effects of lorcaserin in rats Journal of Pharmacology and Experimental Therapeutics 2015 Jan;355(3):381-385. |
| Collins GT, France CP. Determinants of conditioned reinforcing effectiveness: pramipexole-stimulated responding for cocaine-associated stimuli European Journal of Pharmacology 2015 Jan;769:242-249. |
| Serafine KM, Bentley RA, Koek W, France CP. Eating high fat chow but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats Behavioural Pharmacology 2015 Jan;26:321-325. |
| Koek W, Gerak LR, France CP. Effects of amphetamine, morphine, and CP 55,940 on Go/No-Go task performance in rhesus monkeys Behav Pharmacol 2015 Jan;26:481-484. |
| Gerak LR, Zanettini C, Koek W, France CP. Cross tolerance to cannabinoids in morphine-tolerant rhesus monkeys Psychopharmacology 2015 Jan;232:3637-3647. |
| Gerak LR, France CP. Discriminative stimulus effects of pregnanolone in rhesus monkeys Psychopharmacology 2014 Jan;231:181-190. |
| Zanettini C, France CP, Gerak LR. Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: determination of the functional half-life of flumazenil European Journal of Pharmacology 2014 Jan;723:405-409. |
| Serafine KM, France CP. Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) Behavioural Pharmacology 2014 Jan;25:44-52. |
| Baladi MG, Newman AH, France CP. Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats Psychopharmacology 2014 Jan;231:581-591. |
| Serafine KM, Bentley TA, Grenier AE, France CP. Eating high fat chow and the behavioral effects of direct- and indirect-acting dopamine receptor agonists in female rats Behavioural Pharmacology 2014 Jan;25:287-295. |
| Tanno T, Maguire DR, Henson C, France CP. Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentations Psychopharmacology 2014 Jan;231:85-95. |
| Maguire DR, Henson C, France CP. Effects of amphetamine on delay discounting in rats depend upon the manner in which delay is varied Neuropharmacology 2014 Jan;87:173-179. |
| Maguire DR, France CP. Impact of efficacy at the mu opioid receptor on antinociceptive effects of combinations of mu opioid receptor agonists and cannabinoid receptor agonists Journal of Pharmacology and Experimental Therapeutics 2014 Jan;351:383-389. |
| Collins GT, Jackson JA, Koek W, France CP. Effects of dopamine D2-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition European Journal of Pharmacology 2014 Jan;729:123-131. |
| Koek W, Carter, LP, Lamb RJ, Chen, W, Wu, H, Coop, A., France CP. Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam Journal of Pharmacology & Experimental Therapeutics 2005 Jan;314:170-179. |
| Wu H, Zink N, Carter L, Mehta AK, Hernandez RJ, Ticku MK, Lamb RJ, France CP, Coop A. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand Journal of Pharmacology and Experimental Therapeutics 2003 Jan;305:675-679. |
Grants
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Federal |
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| Funding Agency | ASPET |
| Title | ASPET Fellowship Program for Undergraduate Students |
| Status | Active |
| Period | 6/2007 - Present |
| Role | Contributor |
| Grant Detail | |
| Funding Agency | NIH/NIDA |
| Title | Training in drug abuse research: behavior and neurobiology |
| Status | Active |
| Period | 7/2016 - 6/2021 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIDA |
| Title | Behavior, biology and chemistry: translational research in addiction |
| Status | Active |
| Period | 3/2011 - 2/2020 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIDA |
| Title | Discriminative stimulus effects of opioid withdrawal |
| Status | Active |
| Period | 4/1988 - 1/2020 |
| Role | Principal Investigator |
| Grant Detail | Investigate opioid dependence and withdrawal in monkeys and pigeons using drug dependence procedures in order to identify and characterize novel pharmacotherapeutic approaches for the treatment of opioid abuse. |
| Funding Agency | NIH/NIDA |
| Title | Therapeutic potential of kappa opioid/cannabinoid mixtures for treating pain |
| Status | Active |
| Period | 3/2017 - 6/2017 |
| Role | Consultant |
| Grant Detail | |
| Funding Agency | NIH/NIDA |
| Title | The dopamine transporter in eating disorders: uncovering new therapeutic targets |
| Status | Active |
| Period | 6/2014 - 5/2017 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIDA |
| Title | Reinforcing effects of opioid/benzodiazepine mixtures |
| Status | Complete |
| Period | 4/2015 - 3/2017 |
| Role | Co-Investigator |
| Grant Detail | Abuse and overdose of prescription opioids has risen dramatically with most prescription opioid deaths involving at least one other drug, often a benzodiazepine. These studies determine whether opioid/benzodiazepine mixtures are preferred in codependent, but not in nondependent, individuals. |
| Funding Agency | NIH |
| Title | Organic cation transporters as targets for novel antidepressant drugs |
| Status | Active |
| Period | 3/2012 - 11/2016 |
| Role | Co-Investigator |
| Grant Detail | Salary support only. Role is to conduct monoamine uptake assays in mouse brain synaptosomes, to contribute to manuscript preparation and |
State |
|
| Funding Agency | UTHSCSA Center for Biomedical Neuroscience |
| Title | Brain circuits underlying the antidepressant like and abuse related effects of ketamine |
| Status | Active |
| Period | 1/2016 - 12/2016 |
| Role | Contributor |
| Grant Detail | |
Education
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| Year | Degree | Discipline | Institution |
| 1985 | PhD | Psychobiology | University of Michigan Ann Arbor , MI |
| 1984 | MA | Psychobiology | University of Michigan Ann Arbor , MI |
| 1977 | BA | Music | Northland College Ashland , WI |
| Postdoctoral Fellowship | Laboratory of Psychobiology, Department of Psychiatry, Harvard Med School Boston , MA |