Susan Padalecki, Ph.D.
Associate Professor, Urology and Cell Systems and Anatomy
Bone is the most common site of metastases for solid tumors such as breast, prostate and bladder cancers. These metastases contribute significantly to the morbidity and mortality of these cancers.
Significant progress has been made in the understanding of the molecular mechanisms underlying osteolytic bone metastases particularly from breast cancer. However, in advanced prostate cancer and to some degree bladder cancer, patients tend to present with osteoblastic lesions or mixed osteolytic-osteoblastic bone metastases.
Much less is known about the mechanisms leading to these types of bone metastases. Our initial studies have lead to the development of reliable animal models of prostate cancer metastases to bone and bladder cancer metastases to bone. We have also shown that androgen deprivation, a common treatment for advanced prostate cancer, can increase the incidence of bone metastases.
Dr. Susan Padalecki's lab focus is to utilize these models of bone metastasis to dissect the pathophysiology of prostate cancer and bladder cancer metastases to bone as well as for use in pre-clinical testing of therapeutics. Identification of specific molecular targets for the development of therapeutics is a key goal in this work.
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||Cellular and Structural Biology
||UT Health Science Center San Antonio , TX
||Biology (Cum Laude)
||St. Edward's University Austin , TX
||Cancer and Bone Metastases
||UT Health Science Center, Dept of Medicine, Div of Endocrinology San Antonio , TX