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  • Sharp, Zelton D
Dr. Zelton Sharp

Contact

210-567-7228

sharp@uthscsa.edu

Programs

    • M.S. in Personalized Molecular Medicine
    • Ph.D. in Translational Science
    • Ph.D. in Integrated Biomedical Sciences
    • Biology of Aging
    • Cell Biology, Genetics, and Molecular Medicine

Department

    • Department of Molecular Medicine

Zelton Sharp, Ph.D.

Professor, Molecular Medicine

Dr. Z. Dave Sharp's lab explores novel strategies to prevent diseases while mitigating morbidities associated with aging, thereby reducing suffering and looming economic burden. 

They study how chronic mTOR inhibition prevents, delays, and/or reduces the severity of cancer while mitigating other negative effects of aging. 

Their experiments show this is possible with a novel enteric formulation of rapamycin, eRapa. Their current research goals aim to understand the mechanism of action of eRapa in the prevention of colon cancer using mouse models combined with genetic, epigenetic and protein synthesis profiling technologies.

  • Publications
  • Grants
  • Education

Publications

Book Chapter

Sharp ZD. mTOR, Aging and Cancer: Prospects for Pharmacological Interventions. In: Sharp ZD. Anti-aging drugs: from basic research to clinical practice. England: Royal Society of Chemistry; 2017.
Sharp ZD
Hasty, P. mTOR, Aging and Cancer: A dangerous link. In: Editors: Monica Mita, Alain Mita, and Eric K. Rowinsky. mTOR Inhibition for Cancer Therapy. Verlag, France: Springer; 2016. p. 277-292.

Journal Article

Tang, H,
Inoki, K,
Brooks, SV,
Okazawa, H,
Lee, M,
Wang, J,
Kim, M,
Kennedy, CL,
Macpherson, PCD,
Ji, X,
Van Roekel, S,
Fraga, DA,
Wang, K,
Zhu, J,
Wang, Y,
Sharp, ZD,
Miller, RA,
Rando, TA,
Goldman, D,
Guan, K-L,
Shrager, JB. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism Aging Cell 2019 Mar;.
Svatek, R. S., Ji, N., de Leon, E., Mukherjee, N. Z., Kabra, A., Hurez, V., Nicolas, M., Michalek, J. E., Javors, M., Wheeler, K., Sharp, Z. D., Livi, C. B., Shu, Z. J., Henkes, D., and Curiel, T. J. Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer Cancer Immunol Res 2019 Jan;:466-475.
Liss, MA
Rickborn, L
DiGiovanni, J
Bacicha, D
DeGraffenried, LA
Parihar, M
Thompson, IM
Sharp ZD. mTOR inhibitors for treatment of low-risk prostate cancer Medical Hypotheses 2018 Feb;117:63-68.
Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Adaptations to chronic rapamycin in mice Pathobiol Aging Age Relat Dis 2016 Jan;6:31688-31688.
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. p53 and rapamycin are additive Oncotarget 2015 Jun;6(18):15802-15813.
Calhoun, C, Shivshankar, P, Saker, M, Sloane, LB, Livi, CB, Sharp ZD, Orihuela CJ, Adnot, S, White, E, Richardson AG, Le Saux CJ. Senescent cells contribute to the physiological remodeling of aged lungs Journal of Gerontology- Series A: Biological Sciences and Medical Sciences 2015 Jan;70(1):1-9.
Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice Front Mol Neurosci 2014 Nov;7:83-83.
Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Z. Dave Sharp, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction Aging Cell 2014 Jan;13(3):468-477.

Not Specified

Aashish Kabra
Essel Marie de Leon
Carolina Livi
Martin Javors
Marlo Nicolas
David Henkes
Z.Dave Sharp
Tyler Curiel
Robert Svatek. A PHARMACODYNAMIC PHASE 0/I STUDY OF ORAL RAPAMYCIN IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR BLADDER CANCER THE JOURNAL OF UROLOGY 2015 May;193(4s):e810-e810.

Review Article

Paul Hasty
Judith Campisi
Z. Dave Sharp. Do p53 stress responses impact organismal aging? Translational Cancer Research 2016 Jan;5(685-6).

Grants

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Federal

Funding Agency NCI
Title Delaying Intestinal Cancer
Status Active
Period 12/2015 - 11/2020
Role Principal Investigator
Grant Detail

Private

Funding Agency Glenn Foundation
Title Glenn Foundation for Medical Research
Status Complete
Period 9/2010 - Present
Role Principal Investigator
Grant Detail

Funding Agency Barshop Institute for Longevity and Aging Studies
Title Role of SLC38a1 neutral amino acid transporter in mTOR regulation
Status Active
Period - Present
Role Principal Investigator
Grant Detail

Education

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Year Degree Discipline Institution
1981 PhD Cell Biology and Human Anatomy University of Arkansas for Medical Sciences
AR
1975 BS Biology University of Arkansas
Little Rock , AR
1968 BA BBA in Accounting University of Arkansas
Monticello , AR
Postdoctoral Fellowship Depts. of Biology and Biochemistry Rice University
Houston , TX
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UT Health San Antonio
Graduate School of Biomedical Sciences

7703 Floyd Curl Drive

San Antonio, TX 78229

210-567-3709

gsbs@uthscsa.edu

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