Zelton Sharp, Ph.D.
Professor, Molecular Medicine
Dr. Z. Dave Sharp's lab explores novel strategies to prevent diseases while mitigating morbidities associated with aging, thereby reducing suffering and looming economic burden.
They study how chronic mTOR inhibition prevents, delays, and/or reduces the severity of cancer while mitigating other negative effects of aging.
Their experiments show this is possible with a novel enteric formulation of rapamycin, eRapa. Their current research goals aim to understand the mechanism of action of eRapa in the prevention of colon cancer using mouse models combined with genetic, epigenetic and protein synthesis profiling technologies.
Publications
Book Chapter |
| Sharp ZD. mTOR, Aging and Cancer: Prospects for Pharmacological Interventions. In: Sharp ZD. Anti-aging drugs: from basic research to clinical practice. England: Royal Society of Chemistry; 2017. |
| Sharp ZD Hasty, P. mTOR, Aging and Cancer: A dangerous link. In: Editors: Monica Mita, Alain Mita, and Eric K. Rowinsky. mTOR Inhibition for Cancer Therapy. Verlag, France: Springer; 2016. p. 277-292. |
Journal Article |
| Tang, H, Inoki, K, Brooks, SV, Okazawa, H, Lee, M, Wang, J, Kim, M, Kennedy, CL, Macpherson, PCD, Ji, X, Van Roekel, S, Fraga, DA, Wang, K, Zhu, J, Wang, Y, Sharp, ZD, Miller, RA, Rando, TA, Goldman, D, Guan, K-L, Shrager, JB. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism Aging Cell 2019 Mar;. |
| Svatek, R. S., Ji, N., de Leon, E., Mukherjee, N. Z., Kabra, A., Hurez, V., Nicolas, M., Michalek, J. E., Javors, M., Wheeler, K., Sharp, Z. D., Livi, C. B., Shu, Z. J., Henkes, D., and Curiel, T. J. Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer Cancer Immunol Res 2019 Jan;:466-475. |
| Liss, MA Rickborn, L DiGiovanni, J Bacicha, D DeGraffenried, LA Parihar, M Thompson, IM Sharp ZD. mTOR inhibitors for treatment of low-risk prostate cancer Medical Hypotheses 2018 Feb;117:63-68. |
| Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Adaptations to chronic rapamycin in mice Pathobiol Aging Age Relat Dis 2016 Jan;6:31688-31688. |
| Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. p53 and rapamycin are additive Oncotarget 2015 Jun;6(18):15802-15813. |
| Calhoun, C, Shivshankar, P, Saker, M, Sloane, LB, Livi, CB, Sharp ZD, Orihuela CJ, Adnot, S, White, E, Richardson AG, Le Saux CJ. Senescent cells contribute to the physiological remodeling of aged lungs Journal of Gerontology- Series A: Biological Sciences and Medical Sciences 2015 Jan;70(1):1-9. |
| Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice Front Mol Neurosci 2014 Nov;7:83-83. |
| Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Z. Dave Sharp, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction Aging Cell 2014 Jan;13(3):468-477. |
Not Specified |
| Aashish Kabra Essel Marie de Leon Carolina Livi Martin Javors Marlo Nicolas David Henkes Z.Dave Sharp Tyler Curiel Robert Svatek. A PHARMACODYNAMIC PHASE 0/I STUDY OF ORAL RAPAMYCIN IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR BLADDER CANCER THE JOURNAL OF UROLOGY 2015 May;193(4s):e810-e810. |
Review Article |
| Paul Hasty Judith Campisi Z. Dave Sharp. Do p53 stress responses impact organismal aging? Translational Cancer Research 2016 Jan;5(685-6). |
Grants
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Federal |
|
| Funding Agency | NCI |
| Title | Delaying Intestinal Cancer |
| Status | Active |
| Period | 12/2015 - 11/2020 |
| Role | Principal Investigator |
| Grant Detail | |
Private |
|
| Funding Agency | Glenn Foundation |
| Title | Glenn Foundation for Medical Research |
| Status | Complete |
| Period | 9/2010 - Present |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Barshop Institute for Longevity and Aging Studies |
| Title | Role of SLC38a1 neutral amino acid transporter in mTOR regulation |
| Status | Active |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |
Education
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| Year | Degree | Discipline | Institution |
| 1981 | PhD | Cell Biology and Human Anatomy | University of Arkansas for Medical Sciences AR |
| 1975 | BS | Biology | University of Arkansas Little Rock , AR |
| 1968 | BA | BBA in Accounting | University of Arkansas Monticello , AR |
| Postdoctoral Fellowship | Depts. of Biology and Biochemistry | Rice University Houston , TX |