Jose Cavazos, M.D.
Assistant Dean, South Texas Medical Scientist Training Program/ Professor, Neurology
Dr. José Cavazos's lab studies activity-dependent plasticity in the hippocampal formation in the developing, adult, and aged brain using a variety of experimental models of epilepsy, seizures, and epileptogenesis. Previous studies from our laboratory have shown that repeated seizures induce progressive neuronal death and axon sprouting that permanently alter the hippocampal circuitry lending it more susceptible to additional seizures and memory dysfunction.
We currently are investigating the molecular mechanisms that link the synchronous neuronal hyperexcitability with these morphological events. We investigate the features of seizure-induced axon sprouting in other limbic circuitries using anatomical tracing techniques, and their electrophysiological consequences in the neuronal excitability of the abnormally connected circuitry using brain slices and in-vivo using electrophysiological and neuroimaging techniques. We also have several ongoing clinical projects about people with epilepsy, particularly, focusing on the utilization of anticonvulsants.
Publications
Abstract |
| Van Mierlo P, Lie OV, Szabo CA, Cavazos JE, Vandenberghe S. Effect of electrode montage on functional connectivity during an epileptic seizure; 2014 Jun. (2014 Organization for Human Mapping Annual Meeting). |
| Lie OV, Cavazos JE. EEG source imaging of interictal spikes in a patient with focal cortical dysplasia; 2013 Jun. (J Clin Neurophysiol; vol. 30, no. 3). |
| Mukundan L, Jetter G, Moreno L, Rogers S, Gentry W, Carlson S, Cavazos JE. Homocysteinemia associated with anti-epileptic medications- A retrospective study of clinical practice; 2012 Apr. (Neurology; vol. 78). |
| Velez AM, Morgan L, Karkar K, Gherman E, Cavazos JE, Szabo CA. Does Treatment of Depression Before Neurosurgical Intervention For Epilepsy Improve Surgical Outcome?; 2011 Dec. (Abstract No 3.290, 2011, American Epilepsy Society Annual Meeting, www.aesnet.org). |
| Szabo CA, Cavazos JE, Morgan L, Rosales SJ. Epilepsy Partnerships that work: The South Texas Border? Rio Grande Valley Region; 2011 Jan. (Epilepsy Currents). |
| Ntsoane E, Szabo CA, Morgan LC, Mayes BN, Cavazos JE, Bazan C, Cortez A, McCoy KJ, Caron JL. Clinical significance of persistent Fetal PCA in Epilepsy surgery candidates; 2009 Jan. (Neurology; vol. 72). |
| Morgan LC, Cavazos JE, Mayes BN, Szabo CA. Electroclinical and Psychiatric Features of Frontal Opercular Epilepsy: a Report of Five Surgical Cases; 2008 Jan. (Epilepsia (American Epilepsy Society Meeting)). |
| Cross DJ, Jetter GM, Mayes BN, Morgan LC, Szabo CA, Brenner R, Cavazos JE. Interictal high frequency oscillations in temporal lobe epilepsy might predict the location of seizure onset zone; 2008 Jan. (Epilepsia (American Epilepsy Society Meeting)). |
| Yaltho, TC, Gullapalli, BS, Mayes BN, Cavazos JE, Szabo CA. One-Year Outcome of Resective Epilepsy Surgery; 2007 Jan. (Epilepsia (American Epilepsy Society Meeting)). |
| Gullanpalli BS, Cavazos JE, Yaltho TC, Mayes BN, Szabo CA. Epileptic Auras and the Outcome of Temporal Lobectomy; 2007 Jan. (Epilepsia (American Epilepsy Society Meeting)). |
| Szabo CA, Vollmer DG, Cavazos JE, Mayes BN. Electrocortical Mapping of the Occipital Lobe with Subdural Electrodes: Results in Four Patients; 2002 Jan. (Epilepsia (American Epilepsy Society Meeting)). |
Book Chapter |
| Cavazos JE. Chapter 16: SUDEP and Other Risks of Seizures. In: Husain AM, Tran TT. Department of Veterans Affairs: Epilepsy Manual. 2014. p. 205-209. |
| Rogers SJ, Cavazos JE. Chapter 40: Epilepsy. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. DiPiro`s Pharmacotherapy: A Pathophysiologic Approach - 9th Edition. New York, NY, USA: McGraw-Hill/Medical Publishing Division; 2014. p. 855-882. |
Journal Article |
| Szabo CA, Morgan LC, Karkar KM, Leary LD, Lie OV, Girouard M, Cavazos JE. Electromyography-based seizure detector: preliminary results comparing a generalized tonic-clonic seizure detection algorithm to video-EEG recordings Epilepsia 2015 Sep;56(9):1432-1437. |
| Wang Z, Li X, Powers A, Cavazos JE. Outcomes associated with switching from monotherapy to adjunctive therapy for patients with partial onset seizures Expert Review of Pharmacoeconomics & Outcomes Research 2015 Apr;15(2):349-355. |
| Barron DS, Fox PT, Pardoe H, Lancaster J, Price LR, Blackmon K, Berry K, Cavazos JE, Kuzniecky R, Devinsky O, Thesen T. Thalamic functional connectivity predicts seizure laterality in individual TLE patients: application of a biomarker development strategy Neuroimage Clin 2015 Jan;7:273-280. |
| Margolis JM, Chu BC, Wang ZJ, Copher R, Cavazos JE. Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action JAMA Neurol 2014 Aug;71(8):985-993. |
| Burneo JG, Cavazos JE. Neurocysticercosis and epilepsy Epilepsy Currents 2014 Jan;14(1 Sup):23-28. |
| Burneo JG, Delgado JC, Steven DA, Vasquez CM, Alonso-Vanegas MA, Cavazos JE, Mija L, Zapata W, Portilla L. A collaborative effort to establish a comprehensive epilepsy program in Peru Epilepsy and Behavior 2013 Jan;26(1):96-99. |
| Cella D, Lai JS, Nowinski DJ, Victorson D, Peterman A, Miller D, Bethoux F, Heinemann A, Rubin S, Cavazos JE, Reder A, Sufit R, Simuni T, Holmes GL, Siderowf A, Wojna V, Bode R, McKinney N, Podrabsky T, Wortman K, Choi S, Gershon R, Rothrock N, Moy C. Neuro-QOL: Brief Measures of Health-related Quality of Life for Clinical Research in Neurology Neurology 2012 Jan;78(23):1860-1867. |
| Zhang K, Tolstykh GP, Sanchez RM, Cavazos JE. Chronic cellular hyperexcitability in elderly epileptic rats with spontaneous seizures induced by Kainic Acid Status Epilepticus while young adults Aging and Disease 2011 Nov;. |
Review Article |
| Lie OV, Cavazos JE. Responsive neurostimulation in epilepsy therapy: some answers, lingering questions Epilepsy and Behavior 2014 May;34:25-28. |
| Tolstykh GP, Cavazos JE. Potential Mechanisms of Sudden Unexpected Death in Epilepsy Epilepsy and Behavior 2013 Mar;26(3):410-414. |
Education
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| Year | Degree | Discipline | Institution |
| 2016 | Certificate | Business of Health (Summa Cum Laude - GPA 4.0) | University of Texas at San Antonio San Antonio , TX |
| 1997 | Clinical Fellowship | Clinical Neurophysiology / Epilepsy | Duke University Durham , NC |
| 1996 | Residency | Neurology (Chief Resident) | Duke University Durham , NC |
| 1993 | Internship | Internal Medicine | University of Wisconsin - Madison Madison , WI |
| 1993 | PhD | Neuroscience (Cum Laude - GPA 3.98) | University of Wisconsin at Madison Madison , WI |
| 1987 | MD | Medicine (Mencion Honorifica - Cum Laude) | Instituto Tecnologico y de Estudios Superiores de Monterrey Monterrey, Nuevo Leon , Mexico |
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