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  • Aguiar, Ricardo C.
Ricardo Aguiar

Contact

210-567-4860

aguiarr@uthscsa.edu

Programs

    • South Texas Medical Scientist Training Program (MD/PhD Program)
    • Ph.D. in Integrated Biomedical Sciences
    • Cancer Biology
    • Cell Biology, Genetics, and Molecular Medicine
    • Molecular Immunology & Microbiology
Currently seeking Ph.D. students

Ricardo Aguiar, M.D., Ph.D.

Professor of Medicine, Biochemistry, Microbiology, and Immunology

Lymphoma Biology

BCR signaling, transcription factor deregulation, and mitochondrial metabolism

Our group focus is on the identification and functional characterization of the genetic abnormalities of hematologic malignancies. We utilize in vitro and in vivo systems, in genome-wide or targeted studies, with the intent of translating these discoveries into clinical initiatives. The principal disease model in our lab is B-cell lymphoma. Active research lines stem from our recently published work and include: 1) The intersection between B-cell receptor signaling and phosphodiesterase 4 (PDE4) as actionable therapeutic targets in mature B cell malignancies; 2) Metabolic imbalance and epigenetic reprogramming in lymphomas; 3) Transcription factor IRF8 and lymphomagenesis.

Related diseases: B cell lymphomas, lymphoid leukemias

Techniques: Genetic modification of cancer cells in vitro using retrovirus and lentivirus, genetic engineering of mouse models, in vivo (mouse) manipulations, multiple signaling assays, genome-wide analysis (DNA, RNA, and protein) of primary human tumors 

  • Publications
  • Grants
  • Education

Publications

Qiu Z, Lin A-P, Jiang S, Elkashef S, Myers J, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Shiio Y, Aguiar RCT. MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome. CellChem Biol. 2020 Feb 24. [Epub ahead of print] PMID: 32101699

Srikantan S, Deng Y, Cheng Z-M, Luo A, Qin Y, Gao Q, Docor GM, Shannon CE, Fourcaudot M, Li Z, Kasinath BS, Reddick RL, Dong LQ, Abdul-Ghani M, Norton L, Aguiar RCT, Dahia PLM. The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Nature Communications, 10:4720, 2019. PMID: 31624249

Cooney JD, Lin AP, Jiang D, Wang L, Suhasini AN, Myers J, Qiu Z, Wölfler A, Sill H, Aguiar RCT. Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3Kδ in Mature B-cell Malignancies. Clin Cancer Res. 24:1103-1113. 2018. PMID: 29246942

Elkashef SM, Lin AP, Myers J, Sill H, Jiang D, Dahia PLM, Aguiar RCT. IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Cancer Cell,31: 619-620. 2017.PMID: 28486104

Kelly KR, Mejia A, Suhasini A, Lin AP, Kuhn JG, Karnad A, Weitman S, Aguiar RCT. Safety and pharmacodynamics of the PDE4 inhibitor roflumilast in advanced B cell malignancies. Clin Cancer Res,23: 1186-1192, 2017. PMID: 27542768

Cooney JD & Aguiar RCTPhosphodiesterase 4 inhibitors have wide-ranging activity in B cell malignancies. Blood,128: 2886-2890, 2016. PMID: 27756749

Suhasini A, Wang L, Holder K, Lin AP, Bhatnagar H, Kim S-W, Moritz A, Aguiar RCT.A phosphodiesterase 4B-dependent interplay between tumor cells and the microenvironment regulates angiogenesis in B-cell lymphoma Leukemia,30: 617-626, 2016

Lin A-P, Abbas S, Kim S-W, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E,  Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub S, DeBerardinis R, Sill H, Dahia PLM, Aguiar RCT. D2HGDH regulates α-alpha-ketoglutarate levels and dioxygenases function by modulating IDH2. Nature Communications, 6:7768, 2015 - doi: 10.1038/ncomms8768

Bouamar H, Jiang D, Wang L, Lin AP, Ortega M, Aguiar RCT. MicroRNA-155 control of p53 activity is context dependent and mediated by Aicda and Socs1. Molecular and Cellular Biology, 35:1329-40, 2015

Grants

Scroll table right to view more

 

Funding Agency Veterans Administration 2I01 BX001882
Title

IRF8 and lymphomagenesis

Status Active
Period

04/2013- 03/2021

Role Principal Investigator
Grant Detail

$231,076

 

Funding Agency

Cancer Prevention & Research Institute of Texas 

RP190043

Title

Mitochondrial metabolism and RNA methylation in cancer

Status Active
Period

03/2019- 08/2022

Role Principal Investigator
Grant Detail

$285,655

Funding Agency

Leukemia and Lymphoma Society 6524-17

Title

Targeting tumor cell & the microenvironment in DLBCL

Status Active
Period

10/2016- 09/2020

Role

Principal Investigator

Grant Detail

 

Funding Agency

Cancer Prevention & Research Institute of Texas RP170146

Title

B cell receptor signaling intersects with angiogenesis in diffuse large B cell lymphoma.

Status Active
Period

12/2016- 11/2020

Role Principal Investigator
Grant Detail

$285,655

Funding Agency

NIH-NIEHS R01 ES031522 

Title

Oxidative stress and RNA methylation

Status Active
Period

04/2020- 03/2025

Role Principal Investigator
Grant Detail

$250,000

Education

Scroll table right to view more

Year Degree Discipline Institution
1998 Postdoctoral Fellowship Lymphoma Biology Harvard Medical School Boston , MA
1996 Postdoctoral Fellowship Leukemia Biology Centre for Adult Leukaemia, Hammersmith Hospital, University of London London , UK
1994 PhD Leukemia Biology (Magna Cum Laude) University of Sao Paulo, School of Medicine Sao Paulo , Brazil
1992 Clinical Fellowship Hematology & Oncology Hospital das Clinicas, School of Medicine, University of Sao Paulo Sao Paulo , Brazil
1990 Residency Internal Medicine Hospital das Clinicas, School of Medicine, University of Sao Paulo Sao Paulo , Brazil
1988 MD Medicine Federal University of Paraiba Paraiba , Brazil

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UT Health San Antonio
Graduate School of Biomedical Sciences

7703 Floyd Curl Drive

San Antonio, TX 78229

210-567-3709

gsbs@uthscsa.edu

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