Rita Ghosh, Ph.D.
Associate Professor, Urology
Dr. Rita Ghosh's lab research looks at gene-environment interactions that lead to oxidative stress in cancer and to develop ways to target these deregulated pathways as targets for cancer prevention/therapy.
The lab uses a variety of cell culture and animal models (immunocompromised and transgenic rodents) in our research. Our in vitro studies use a combination of genomic, biochemical and molecular biology approaches to study cancers including melanoma, bladder and prostate cancers. Our candidate compounds are of botanical origin including those that are used as culinary spices. We have created many derivatives of such compounds to test structure-activity of compounds for potential anti-cancer activities.
Publications
Abstract |
| Hambright HG., Kumar AP., Ghosh R. Inhibition of melanoma cell survival through p62/LC3B autophagic signaling; 2016 Jan. (Proceedings of the American Association for Cancer Research). |
| Mukherjee N., Ghosh R. A novel mechanism of NFkB regulation in bladder cancer; 2015 Jan. (Proceedings of the American Association for Cancer Research). |
| Hambright HG., Kumar AP., Ghosh R. Therapeutic targeting of redox-autophagy interplay as a strategy for melanoma management (Gordon Research Conference: Oxidative Stress & Disease); 2015 Jan. |
| Suleman S. Hussain, Paul Rivas, Roble Bedolla, Nikos Papanikolaou, Robert L. Reddick, Brad H. Pollock, Daniel C. Chan, Rita Ghosh and Addanki P. Kumar. Downregulation of ribosomal protein rpS6 overcomes radioresistance in prostate cancer; 2015 Jan. (Proceedings of the American Association for Cancer Research). |
| Meng P., Ghosh R. E2F1 deficiency causes increased migration through upregulation of MYLK; 2014 Jan. (Proceedings of the American Association for Cancer Research). |
| Tiffani J Horton, Eduardo Cardenas, Neelam Mukherjee, and Rita Ghosh. A functional study of ANGPTL4 in the human bladder-Keystone Conference on Transcription Regulation; 2014 Jan. |
| Yun, HY., Xie, J., Batth, I., Li, R., Ghosh, R., Kumar, AP. ER-β/Sp/NFκB/FLIP axis: Potential therapeutic target in prostate cancer; 2014 Jan. (Proceedings of the American Association for Cancer Research). |
| Amanda R. Mu?oz, Jingjing Gong, Divya Chakravarthy, Daniel E. Chan, James W. Freeman, Rita Ghosh, and Addanki P. Kumar. Targeting the Stat3/NF-κB/EP4 signaling axis through combination treatment with Nexrutine and Gemcitabine for pancreatic cancer (AACR Pancreatic Cancer: Innovations in Research and Treatment); 2014 Jan. |
| Mukherjee N., Ghosh R. SETD6-Mediated Deregulation of NF-kB Signaling in 4-ABP-Induced Bladder Carcinogenesis; 2013 Jan. (Proceedings of the American Association for Cancer Research). |
| Thapa D., Kumar Ap., Ghosh R. NAD(P)H quinone oxidoreductase 1 regulates pro-inflammatory mediators associated with prostate tumorigenesis; 2013 Jan. (Proceedings of the American Association for Cancer Research). |
| Cardenas E., Horton TJ., Ghosh R. A functional study of ANGPTL4 in human bladder cancer; 2013 Jan. (Proceedings of the American Association for Cancer Research). |
Book Chapter |
| Hussain SS., Patel D., Ghosh, R. Kumar AP. Extracting the Benefit for Cancer Prevention. In: Kumar AP.,Hussain SS., Ghosh, R. Current Pharmacology Reports. Springer: Springer Science; 2015. |
Journal Article |
| Ghosh R, Rivas P, Li G, Smith ML, Hawes ML, Bedolla R, Lucia MS, Reddick RL, and Kumar AP. Inhibition of prostatic intraepithelial neoplalsia as a prostate cancer prevention strategy (under preparation) 2017 Jan;. |
| Mukherjee N, Cardenas E, Bedroll RG, and Ghosh R. SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer Oncotarget 2017 Jan;8(9):15114-15125. |
| Jingjing Gong, Amanda R Mu?oz, Florastina Payton-Stewart, Daniel E Chan, James W Freeman, Rita Ghosh, and Addanki P Kumar. Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells Molecular Carcinogenesis 2017 Jan;56:402-411. |
| Peng Meng, Roble G Bedolla, Huiyoung Yun, James E Fitzpatrick, Addanki P Kumar, Rita Ghosh. E2F1 suppresses Myosin Light Chain Kinase to regulate cytoskeletal changes associated with melanoma progression (under preparation) 2017 Jan;. |
| Hambright HG, Meng P, Kumar AP, Ghosh R,. Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells Oncotarget 2015 Jan;6(9):7195-7208. |
| Hambright HG, Batth IS, Xie J, Ghosh R, Kumar AP. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP Molecular Carcinogenesis 2015 Jan;54(10):1227-1234. |
| Jingjing Gong, Amanda R Munoz, Daniel Chan, Rita Ghosh and Addanki P Kumar. STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growtH Oncotarget 2014 Jan;5:2529-2541. |
| Thapa D, Meng P, Bedolla RG, Reddick RL, Kumar AP AND Ghosh R. NQO1 suppresses NF-kB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis Cancer Research 2014 Jan;74(5644):5644-5655. |
| Li G, Rivas P, Bedolla R, Thapa D, Reddick RL, Ghosh R, Kumar AP. Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis Cancer Prevention Research 2013 Jan;6(1):27-39. |
| Nair HB, Bhaskaran S, Pathak S, Ghosh R, Dunn B, Moore CM, Vanderberg JL. 1205Lu Human metastatic melanoma cells, not human! J Cancer Sci Ther 2013 Jan;. |
Review Article |
| Hambright HG., Ghosh R. Autophagy: In the cROSshairs of melanoma therapeutics? BioChemical Pharmacology 2017 Jan;126:13-22. |
| Suleman S Hussain, Addanki P Kumar, Rita Ghosh. Food-based natural products for cancer management: Is the whole greater than the sum of the parts? Seminars in Cancer Biology 2016 Jan;40-41:233-246. |
| Thanpa D., Ghosh R. Chronic inflammatory mediators enhance prostate cancer development and progression Biochemical Pharmacology 2015 Jan;94(2):53-62. |
| Mukherjee N, Kumar AP, Ghosh R. DNA Methylation and Flavonoids in Genitourinary Cancers Curr Pharmacol Rep 2015 Jan;1(2):112-120. |
| Mukherjee N1, Houston TJ1, Cardenas E1, Ghosh R2. To be an ally or an adversary in bladder cancer: the NF-κB story has not unfolded Carcinogenesis 2015 Jan;36(3):299-306. |
| Meng P., Ghosh R. Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy? Cell Death and Disease 2014 Jan;5. |
| Cardenas, E., & Ghosh R. Vitamin E: A dark horse at the crossroad of cancer management Biochemical Pharmacology 2013 Jan;86(7):845-852. |
Grants
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Federal |
|
| Funding Agency | NIH 1R01 |
| Title | Oxidative stress in prostate cancer: Efficacy of Antioxidants in Nkx3.1/Pten model |
| Status | Active |
| Period | 1/2010 - 2/2017 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH/NCI |
| Title | Oxidative stress in prostate cancer: Efficacy of antioxidants in Nkx3.1; Pten model |
| Status | Active |
| Period | 9/2013 - 6/2016 |
| Role | Principal Investigator |
| Grant Detail | |
State |
|
| Funding Agency | Cancer Prevention Research Institute of Texas |
| Title | RP150166 |
| Status | Active |
| Period | 3/2015 - 2/2018 |
| Role | Co-Investigator |
| Grant Detail | |
Education
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| Year | Degree | Discipline | Institution |
| 1990 | PhD | Life Science | School of Life Sciences, University of Hyderabad India |
| 1984 | MS | Life Science | School of Life Sciences, University of Hyderabad India |
| Postdoctoral Training | Molecular Cancer Biology | MD Anderson Cancer Center Smithville , TX | |
| Postdoctoral Training | Molecular Biology | Texas A&M University College Station , TX |