Gregory Aune, M.D.

Assistant Professor of Pediatrics

Dr. Aune was born in Eastern Washington State and grew up on a wheat farm. At age 16 he was diagnosed with Hodgkin’s Lymphoma and was successfully cured of his disease after undergoing one year of chemotherapy and radiation treatments. His cancer experience led Dr. Aune down a path to becoming a pediatric oncologist and physician scientist.

He attended Pacific Lutheran University in Tacoma, Washington, where he graduated Summa Cum Laude with separate degrees in chemistry and biology. From there he moved to Texas and pursued training in both medicine and basic science.

In 2001, he moved to the Washington D.C. area with his wife and continued graduate work at the National Cancer Institute (NCI), under the supervision of Yves Pommier, MD, PhD, director of the Laboratory of Molecular Pharmacology. Throughout the next four years, Dr. Aune continued educational activities at the University of Texas-Houston and MD Anderson Cancer Center, while conducting his research at NCI. In 2005, he graduated from the University of Texas-Houston with an MD and PhD in the field of tumor biology and experimental therapeutics. The focus of Dr. Aune’s PhD dissertation was the molecular mechanism of cytotoxicity of the novel DNA minor groove alkylator, Ecteinascidin 743. Dr. Aune completed his pediatrics residency at Johns Hopkins Hospital in Baltimore, MD in 2008 and subspecialty training in hematology-oncology in 2010 here at UT Health San Antonio.

During the beginning months of his hematology-oncology fellowship, Dr. Aune underwent open heart surgery to replace his aortic valve and bypass three blocked coronary arteries – the direct result of chemotherapy and radiation he had received 20 years prior. Similar to his teenage battle with cancer, this personal struggle guided his academic path towards developing a laboratory program investigating the basic science of pediatric cancer survivorship. He is the first graduate of the Pediatric hematology-oncology fellowship supported generously by Mr. Bill Greehey and Greehey CCRI.

Dr. Aune is board certified in both general pediatrics and hematology-oncology and maintains membership and actively participates in numerous national organizations devoted to childhood cancer research and cancer survivorship.

He is married to Christine, a major and neonatologist in the United States Army. They are blessed with two sets of twins, ages eight and three.

Publications

Lindsey, M. L., Lange, R. A., Parsons, H., Andrews, T. & Aune, G. J. The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure. Am. J. Physiol. Heart Circ. Physiol. 307, H1379-89 (2014). PMID: 25217655; PMCID: PMC4233297

Pan, H., Qin, K., Guo, Z., Ma, Y., April, C., Gao, X., Andrews, T. G., Bokov, A., Zhang, J., Chen, Y., Weintraub, S. T., Fan, J. B., Wang, D., Hu, Y., Aune, G. J., Lindsey, M. L. & Li, R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell. Rep. 7, 79-85 (2014). PMID: 24656816; PMCID: PMC4277258

Publications

Abstract

Mark Gorelik, Youngho Lee, Masanori Abe, Thomas Andrews, Jean Patterson, Magali Noval Rivas, Gregory Aune and Moshe Arditi. Anakinra Treatment Prevents Myocardial Mechanical Dysfunction and Inhibits Histologic Evidence of Myocardial Inflammation in the Mouse Model of Kawasaki Disease; 2018 Oct. (Arthritis and Rheumatology).

Mancilla TR, Aune GJ. Doxorubicin Alters Cardiac Fibroblast Phenotype; 2018 Aug. (Circulation Research).

Mancilla TR, Aune GJ. Damage Response in Doxorubicin-Exposed Cardiac Fibroblasts; 2018 May. (The FASEB Journal).

T Andrews, G Aune. Long-Term Cardioprotective Efficacy of Dexrazoxane and Liposomal Doxorubicin Evaluated in a Murine Model of Early Doxorubicin Treatment; 2017 Jan. (Pediatric Blood and Cancer).

TA Mancilla, GJ Aune. Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation; 2017 Jan. (Journal of Clinical and Translational Sciences).

S Shah, GJ Aune, L Mette, N Poullard. Successful integration of genetic counseling in a comprehensive childhood cancer survivorship clinic; 2017 Jan. (Journal of Clinical Oncology).

TL Harris, GJ Aune. Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model; 2016 Jan. (Circulation Research).

TL Harris, T Andrews, GJ Aune. Late Effects of Early Anthracycline-Induced Cardiotoxicity in Pediatric Mouse Model; 2016 Jan. (FASEB Journal).

TA Mancilla, T Andrews, G Aune. Doxorubicin-Induced Chronic Upregulation of Transforming Growth Factor-beta; 2016 Jan. (The FASEB Journal).

Aune, MD, PhD, FAAP GJ. The Lifelong Health Burden of Successful Childhood Cancer Treatment; 2015 Jan. (Gerontologist).

Editorial

Aune, MD, PhD, FAAP GJ. Star Act is a victory for children with cancer San Antonio Express-News 2018 Jun;.

Aune, MD, PhD, FAAP GJ. Childhood Cancer Needs More Attention San Antonio Express-News 2017 Sep;.

Aune, MD, PhD, FAAP GJ. Value Isn`t Just About Surviving Cancer Axios 2017 Sep;.

Aune, MD, PhD, FAAP GJ. Research Priorities for Childhood Cancer Survivors National Coalition for Cancer Survivorship- Post Election Blog 2016 Dec;.

Aune, MD, PhD, FAAP GJ. Reality Check: We are Nowhere Close to Solving the Problem of Childhood Cancer St. Baldrick's Foundation Advocacy Blog 2016 Jul;.

Electronic/Web Publication

Aune, MD, PhD, FAAP GJ. Chemotherapy Exposure and EKG Changes: What Do They Mean? 2017 Oct. Available from: https://cancerkn.com/chemotherapy-exposure-ekg-changes-mean/ .

Aune, MD, PhD, FAAP GJ. What is the International Consensus on Screening for Heart Problems in Childhood Cancer Survivors? 2017 Oct. Available from: https://cancerkn.com/international-consensus-screening-heart-problems-ch... .

Aune, MD, PhD, FAAP GJ. We Must Consider New Strategies to Deliver Health Care to Childhood Cancer Survivors 2017 Sep. Available from: https://cancerkn.com/must-consider-new-strategies-deliver-health-care-ch... .

Aune, MD, PhD, FAAP GJ. The Financial Impact of Surviving Childhood Cancer 2017 Sep. Available from: https://cancerkn.com/financial-impact-surviving-childhood-cancer/ .

Aune, MD, PhD, FAAP GJ. Risk Factors for Decreased Bone Mineral Density in Survivors of Childhood Cancer 2017 Aug. Available from: https://cancerkn.com/risk-factors-decreased-bone-mineral-density-survivo... .

Aune, MD, PhD, FAAP GJ. From the Lab: Scientists Pinpoint Genetic Changes in Radiation-induced Meningiomas 2017 Aug. Available from: https://cancerkn.com/lab-scientists-pinpoint-genetic-changes-radiation-i... .

Aune, MD, PhD, FAAP GJ. New Biomarker Predicts Late Neurocognitive Deficits in Adult Survivors of Childhood Leukemia 2017 Jul. Available from: https://cancerkn.com/new-biomarker-predicts-late-neurocognitive-deficits... .

Aune, MD, PhD, FAAP GJ. Childhood ALL: Increased Survival Leads to a Greater Emphasis on Preserving Neurocognitive Function 2017 Jul. Available from: https://cancerkn.com/childhood-increased-survival-leads-greater-emphasis... .

Aune, MD, PhD, FAAP GJ. Aging Survivors and Endocrine Disorders 2017 Jul. Available from: https://cancerkn.com/aging-survivors-endocrine-disorders/ .

Aune, MD, PhD, FAAP GJ. Neurocognitive Function, Sleep, and Fatigue in Female Childhood ALL Survivors 2017 Jul. Available from: https://cancerkn.com/neurocognitive-function-sleep-fatigue-female-childh... .

Aune, MD, PhD, FAAP GJ. Childhood Cancer Survivors: Does chemotherapy alone increase second cancer risk? 2017 Jun. Available from: https://cancerkn.com/childhood-cancer-survivors-chemotherapy-alone-incre... .

Aune, MD, PhD, FAAP GJ. Decreased Therapy Results in Fewer Second Cancers 2017 Jun. Available from: https://cancerkn.com/decreased-therapy-results-fewer-second-cancers/ .

Aune, MD, PhD, FAAP GJ. Mental Distress in Survivors: Highly Prevalent and Undertreated 2017 Jun. Available from: https://cancerkn.com/mental-distress-survivors-highly-prevalent-undertre... .

Aune, MD, PhD, FAAP GJ. Pregnancy in Female Cancer Survivors: Increased Risks for Mother and Baby 2017 Jun. Available from: https://cancerkn.com/pregnancy-female-cancer-survivors-increased-risks-m... .

Aune, MD, PhD, FAAP GJ. Chemotherapy More Effective at Causing Programmed Cell Death in Young Tissues 2017 Jun. Available from: https://cancerkn.com/chemotherapy-effective-causing-programmed-cell-deat... .

Aune, MD, PhD, FAAP GJ. What Factors are Associated with Hearing Loss in Childhood Cancer Survivors Treated with Platinum Agents? 2017 May. Available from: https://cancerkn.com/factors-associated-hearing-loss-childhood-cancer-su... .

Aune, MD, PhD, FAAP GJ. Benign Tumors with a Not-so-benign Impact: Meningiomas in Childhood Cancer Survivors 2017 May. Available from: https://cancerkn.com/benign-tumors-not-benign-impact-meningiomas-childho... .

Aune, MD, PhD, FAAP GJ. First Live Births Less Common in Cancer Survivors 2017 May. Available from: https://cancerkn.com/first-live-births-less-common-cancer-survivors/ .

Aune, MD, PhD, FAAP GJ. Introducing Dr. Gregory Aune, Editor, Knowledge Translation: Childhood Cancer Survivorship 2017 May. Available from: https://cancerkn.com/introducing-dr-gregory-aune-editor-knowledge-transl... .

Aune, MD, PhD, FAAP GJ. Hodgkin Lymphoma Survivors at High Risk of Second Cancers 2017 May. Available from: https://cancerkn.com/hodgkin-lymphoma-survivors-high-risk-second-cancers/ .

Aune, MD, PhD, FAAP GJ. A Defining Moment for Childhood Cancer 2015 May. Available from: https://medium.com/@gregoryjaune/a-defining-moment-for-childhood-cancer-... .

Journal Article

Feijen, EA, Leisenring, WM, Stratton, KL, Ness, KK, Van der Pal, HJ, Van Dalen, EC, Armstrong, GT, Aune, GJ, Green, DM, Hudson, MH, Loonen, J, Oeffinger, KC, Robison, LL, Yasui, Y, Kremer, LC, and Chow, EJ. Derivation of anthracycline equivalence to doxorubicin for late- onset cardiotoxicity: mitoxantrone and epirubicin JAMA Oncology 2018 Aug;.

Armenian, SH, Armstrong, GT, Aune, GJ, Chow, EJ, Ehrhardt, MJ, Ky, B, Moslehi, J, Mulrooney, DA, Nathan, PC, Ryan, TD, van der Pal, HJ, van Dalen, EC, and Kremer, LC. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention Journal of Clinical Oncology 2018 Jun;.

Mancilla, TA, Iskra, B, and Aune, GJ. Doxorubicin-induced Cardiomyopathy in Children. Comprehensive Physiology Comprehensive Physiology 2018 May;.

Wang, F, Iskra, BS, Wang F, Kleinerman, E, Alvarez-Florez, C, Andrews, TA, Shaw, A, Yu, L, Chandra, J, Schadler K, Aune GJ. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity Journal of Pediatric Hematology Oncology 2018 Apr;.

Aune, MD, PhD, FAAP GJ. Healthcare Delivery for Childhood Cancer Survivors The Lancet 2017 Dec;.

Lindsey ML, Lange RA, Parsons H, Andrews T, Aune GJ. The Tell-Tale Heart: Molecular and Cellular Responses to Childhood Anthracycline Exposure Am J Physiol Heart Circ Physiol 2014 Sep;12.

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes Cell Rep 2014 Apr;10;7(1):79-85.

Andrews TG, Lindsey ML, Lange RA, Aune GJ. Cardiac Assessment In Pediatric Mice: Strain Analysis as a Diagnostic Measurement Echocardiography 2014 Mar;31(3):375-384.

Grants

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Federal
Funding Agency	NIH
Title	NIH R01 grant HL138093-01
Status	Active
Period	7/2017 - 6/2021
Role	Co-Investigator
Grant Detail	The goal of this project is to determine whether the degradation of mitochondrial inner membrane protein disrupts the structural interaction between mitofilin and cyclophilin D and determines the extent of ischemia/reperfusion injury.
Private
Funding Agency
Title	Boerne High School Go Gold
Status	Active
Period	9/2018 - 8/2019
Role	Principal Investigator
Grant Detail	Direct donation to the Aune laboratory. Funds will be used to perform Single Cell RNAseq expiriments on non-myocyte cells isolated from mouse hearts.
Funding Agency	St. Baldrick?s Foundation
Title	St. Baldrick?s Foundation Scholar Grant
Status	Active
Period	9/2014 - 8/2019
Role	Principal Investigator
Grant Detail	Evaluate the long-term cardiac outcomes in mice exposed to liposomal encapsulated doxorubicin
Funding Agency	Turn it Gold Foundation
Title	Turn it Gold Foundation
Status	Active
Period	7/2017 - 6/2019
Role	Principal Investigator
Grant Detail	The overall goal of this project is to facilitate basic laboratory investigations with relevance to childhood cancer late effects. Focus areas have been thrombin-generating potential of plasma isolated clinical populations of survivors and the generation of new transgenic mice strains used to test hypotheses implicating anthraycline-induced damage in cardiac fibroblasts as a contributor to long-term cardiac toxicity.
Funding Agency	San Antonio Medical Foundation
Title	San Antonio Medical Foundation
Status	Active
Period	7/2018 - 6/2019
Role	Co-Principal Investigator
Grant Detail	This is a collaborative grant with investigators from UTSA and Texas Biomedical Institute focused on Kawasaki disease , which is a common infectious disease of childhood, whose after-effects cause lifelong damage to the heart. Our collaborative project seeks to leverage unique skills and already ongoing work in San Antonio to develop novel biomarkers and potentially avenues for new treatments for this disease. Our approach is to evaluate proteins from the heart tissue of mice affected with this disease, and correlate this to disease activity, functional changes and translate this to human samples.
Funding Agency	Pablove Foundation
Title	Pablove Foundation Childhood Cancer Research Seed Grant
Status	Active
Period	7/2016 - 6/2018
Role	Principal Investigator
Grant Detail	The overall goal of this project is to utilize our novel mouse model of early anthracycline exposure to evaluate the cardiotoxic equivalence of the six most commonly used anthracyclines in clinical populations.
State
Funding Agency	UTHSA Long School of Medicine
Title	Clinical Investigator Kickstarter Grant
Status	Active
Period	9/2018 - 8/2019
Role	Co-Principal Investigator
Grant Detail	The goal of this grant is to evaluate plasma from long-term childhood cancer survivors with respect to thrombin-generating potential. With the epidemiological observation that survivors are more prone to thrombotic processes, stroke and myocardial infarction, this study seeks to establish the underlying mechanisms for these clinical observations.

Education

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Year	Degree	Discipline	Institution
2010	Clinical Fellowship	Pediatrics Hematology/Oncology	University of Texas Health Science Center San Antonio , TX
2008	Residency	Pediatrics	Johns Hopkins Hospital Baltimore , MD
2006	Internship	Pediatrics	Johns Hopkins Hospital Baltimore , MD
2005	PhD	Biomedical Sciences	University of Texas at Houston Houston , TX
2005	MD	Medicine	University of Texas at Houston Houston , TX
1997	BS	Chemistry (Biochemistry emphasis) (Summa Cum Laude)	Pacific Lutheran University Tacoma , WA
1997	BA	Biology (Summa Cum Laude)	Pacific Lutheran University Tacoma , WA

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Gregory Aune, M.D.

Assistant Professor of Pediatrics

Publications

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Editorial

Electronic/Web Publication

Journal Article

Grants

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Education

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UT Health San Antonio

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