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  • Wargovich, Michael J
Michael Wargovich

Contact

210-567-8230

wargovich@uthscsa.edu

Programs

    • Graduate Certificate in Cancer Prevention Program
    • M.S. in Clinical Investigation & Translational Science
    • M.S. in Personalized Molecular Medicine
    • Ph.D. in Translational Science
    • South Texas Medical Scientist Training Program (MD/PhD Program)
    • Ph.D. in Integrated Biomedical Sciences
    • Cancer Biology

Michael Wargovich, Ph.D.

Professor, Molecular Medicine

Our laboratory investigates ways to prevent colon cancer. Our focus is on the chemoprevention of cancer - “Chemoprevention” is a discipline of cancer research that is less than 20 years old and embraces the idea that cancer can be prevented or precancers can be inhibited from progressing to cancer by the use of natural compounds or pharmaceuticals.  We study cancer biology using a number of human cancer cell lines and also utilize novel animal models for colon cancer.  Natural products can include substances from wine and green tea, fruits and vegetables, compounds in herbs and spices, vitamins and minerals, and dietary supplements. The lab has an interest in both terrestrial and marine botanicals. Via the pharmaceutical route, drug development has led to the discovery of compounds like tamoxifen for the prevention of breast cancer, aspirin for colon cancer.

  • Publications
  • Grants
  • Education

Publications

Journal Article

Showler, AT, Osbrink, WL, Morris JL, Wargovich MJ. Effects of two commercial neem-based insecticides on lone star tick, Amblyomma americanum (L.) (Acari: Ixodidae): deterrence, mortality, and reproduction Biopesticides International 2017 Jun;13(1):1-16.
Ramirez AG, Long-Parma, D., Munoz, E., Mendoza, K.D., Harb, C., Holden, A.E., Wargovich, m. An anti-inflammatory dietary intervention to reduce breast cancer recurrence risk: Study design and baseline data Contemporary Clinical Trails 2017 Jun;57:1-7.
Morris J, Moseley VR, Cabang AB, Coleman K, Wei, W, Garrett-Mayer, E and Wargovich MJ. Reduction in promotor methylation utilizing EGCG (Epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells Oncotarget 2016 May;7(23):35313-35326.

Not Specified

Patel MJ, Tripathy S, Mukhopadyay, KD, Morris, J, Wargovich MJ. A supercritical extract of Neem leaf (A. indica and its bioactive liminoid, nimbolide suppress colon cancer in preclinical models by modulating pro-inflammatory pathways Molecular Carcinogenesis 2018 Jan;.
Cabang AB, De Mukhopadhyay K, Meyers S, Morris J, Zimba PV, Wargovich MJ. Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin in colon cancer Oncotarget 2017 Nov;8(61):104347-104358.
Luo H, Yang A, Schulte BA, Wargovich MJ, Wang GY. Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage Plos one 2013 Jan;8(3):60065-60070.

Review Article

Khoogar R, Kim BY, Morris J, Wargovich MJ. Targeting the Progression of Cancer with Natural Products: A Focus on Gastrointestinal Cancer Am J of Physiol Gastro and Liver Physiol 2016 Apr;310:G629-G644.

Grants

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Private

Funding Agency Morrison Trust
Title Maximizing Dietary Vitamin D to Alleviate Chronic Colitis
Status Complete
Period 8/2016 - 12/2017
Role Co-Investigator
Grant Detail
Funding Agency Morris L. Lichtenstein, Jr. Medical Research Foundation
Title Extended Studies of Euglenophycin for Cancer Prevention and Treatment
Status Active
Period 3/2014 - 12/2017
Role Principal Investigator
Grant Detail

State

Funding Agency University of South Carolina
Title Herbal and Botanical Preventives for Colon Cancer
Status Complete
Period - Present
Role Principal Investigator
Grant Detail Research & Productive Scholarship Grant
Funding Agency CPRIT
Title Chemoprevention of Colon Cancer by Anti-inflammatory Blockade Using Neem
Status Active
Period 3/2016 - 8/2019
Role Principal Investigator
Grant Detail

Education

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Year Degree Discipline Institution
1981 PhD Microbiology Texas Tech University
Lubbock , TX
1977 MS Biological Sciences Duquesne University
Pittsburgh , PA
1974 BA Biology Washington and Jefferson College
Washington , PA
Postdoctoral Fellowship Biomedical Sciences OVC, University of Guelph
Guelph, Ontario , Canada
Postdoctoral Fellowship Medical Biophysics Ontario Cancer Institute
Toronto, Ontario , Canada
Postdoctoral Fellowship Cancer Prevention Research Ludwig Institute for Cancer Research, Toronto Branch for Human Cancer Preve
Toronto, Ontario , Canada
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UT Health San Antonio
Graduate School of Biomedical Sciences

7703 Floyd Curl Drive

San Antonio, TX 78229

210-567-3709

gsbs@uthscsa.edu

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