Bartell Zachry Distinguished Professor for Research in Neurodegenerative Disorders
We study the basic neurobiology underlying brain aging and neurodegeneration, with a strong emphasis on Alzheimer's disease and related tauopathies. We employ a multi-system approach to rapidly identify, test, and validate hypotheses that are relevant to human disease. Early discovery takes place in Drosophila, a model organism that is well suited for investigating issues of causality in disease processes. To determine if our studies are relevant to human disease, we complement Drosophila work with neuropathological and computational analyses of mouse and postmortem human brain. A major focus of the laboratory is on tau-induced activation of transposable elements and the effects of tau on nuclear and genomic architecture.
Research Area/Field of Study: Neurodegeneration, brain aging