Lizhen Chen, Ph.D.
Assistant Professor, Department of Cell Systems and Anatomy
Genetics and Neurobiology | Neuronal aging and regeneration
The goal of Dr. Lizhen Chen's research is to discover the molecular pathways involved in neuronal aging and disease and to translate such findings into potential therapeutic targets. Specifically, our research focuses on the molecular mechanisms of neuronal aging, degeneration and age-dependent axon regeneration. We use C. elegans and mouse models in our research. The short life span and powerful genetics of C. elegans offer a unique advantage for understanding the molecular and cellular mechanisms underlying neuronal aging. The findings from C. elegans will then be applied to mammals.
Related diseases: Neurodegeneration and Neuron injury
Techniques: Genetic screening, Genomic approaches, and Live imaging
|Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld M, Fu X, Chisholm A, and Jin Y. RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of syntaxins eLife 2016 Jun;5(16072).
|Chen L, Chuang M, Koorman T, Boxem M, Jin Y and Chisholm A. Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase eLife 2015 Sep;08695.
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||University of Georgia, Laboratory of Dr. Nancy R. Manley
Athens , MI
Lanzhou, Gansu , P.R. China