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Habil Zare, Ph.D.
Assistant Professor, Department of Cell Systems and Anatomy
Computational Biology and Bioinformatics
Cancer Research and Neuroscience
Oncinfo is a research lab at the University of Texas Health Science Center at San Antonio. The focus of our projects is on bioinformatics and computational biology. We develop and apply sophisticated machine learning algorithms to analyze large biological, or clinical, data sets. From these complex data sets, our goal is to infer useful information which provides insight into biology or leads to clinical applications. Oncinfo contributes to neuroscience through collaboration with The Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. Also, several cancer research projects are defined in collaboration with the Department of Cell Systems and Anatomy. Our external collaboration includes the British Columbia Cancer Agency, which has a great research reputation in oncology around the world. Oncinfo welcomes further collaborators from related disciplines such as medicine, molecular and cellular biology, pharmacology, computer science, and statistics. We are particularly interested in collaboration with R&D departments of top pharmaceutical companies.
Related Diseases: Cancer, Alzheimer's disease and other neurodegenerative disorders
Techniques: Machine learning, analysis of next-generation sequencing data, statistical analysis, computer programing
Publications
Representative Publications:
Sun W, Samimi H, Gamez M, Zare H, Frost B. Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci. 2018 Aug;21(8):1038-1048.
Foroushani A, Agrahari R, Docking R, Chang L, Duns G, Hudoba M, Karsan A, Zare H. Large-scale gene network analysis reveals the significance of extracellular matrix pathway and homeobox genes in acute myeloid leukemia: an introduction to the Pigengene package and its applications. BMC Med Genomics. 2017 Mar 16;10(1):16.
Zare H, Wang J, Hu A, Weber K, Smith J, Nickerson D, Song C, Witten D, Blau CA, Noble WS.Inferring Clonal Composition from Multiple Sections of a Breast Cancer. PLoS Comput Biol. 2014 Jul 10;10(7):e1003703.
Recent Publications:
Education
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Ph.D., The University of British Columbia, 2011