Jason Pugh, Ph.D.
Assistant Professor, Cellular and Integrative Physiology
A fundamental question in neuroscience is how neurons receive, process, and transmit signals. At the cellular level, neurons transmit signals primarily through synaptic connections. Synapses are remarkably diverse in transmitter, receptor expression (pre- and postsynaptic), kinetics, and short/long-term plasticity. Each of these properties influences how information is transmitted and stored at the synapse. We are interested in understanding how synaptic properties are fine-tuned to function within specific circuits and process information.
Diseases Associated: Ataxia, Muscular Dystrophy, Autism, Epilepsy
Techniques Used: Patch-clamp electrophysiology, calcium imaging, two-photon laser scanning microscopy, optogenetics
Specific Field of Study: Presynaptic receptors
Sub-Field of Study: Synaptic physiology
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Ph.D., Neuroscience, Northwestern University, 2008
B.S., Biology, Stanford University, 2000