The laboratory of Dr. Naomi Sayre is interested in the processes that affect repair and recovery after brain damage, with particular emphasis on the role that cholesterol homeostasis plays in these processes. Our research focuses on understanding how cholesterol homeostasis affects two cell types-astrocytes and neural stem cells. As the primary supportive cells in the brain, astrocytes also regulate cholesterol homeostasis, and so have unique potential to affect recovery after brain damage due to trauma or stroke. Neural stem cells travel to the site of brain injury, where they play a role in recovery that has not been fully elucidated.
Naomi L. Sayre , Mikaela Sifuentes, Deborah Holstein, Sheue-yann Cheng, Xuguang Zhu, James D. Lechleiter. Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage. JCBFM in press.