Xiaodu Wang, Ph.D.

My research interests lie in the area of mechanics of biological materials and structures, including ultrastructural origins of bone fragility fractures, digital model of trabecular bone and its application in deep learning prediction of bone fractures, and prediction/prevention of bone fragility fractures. I have been serving as PI for multiple NIH (R03, R21s and R01s) and NSF supported projects.

Related Diseases: Osteoporosis, osteopenia, osteogenesis imperfecta and diabetes

Techniques: MicroCT, synchrotron X-ray scattering, light and confocal microscopy, FTIR, Raman spectroscopy, SEM, TEM, AFM, NMR/MRI, DXA, HPLC and Mechanical testing

• Research & Grants

  My research interests lie in the area of mechanics of biological materials and structures, including ultrastructural origins of bone fragility fractures, digital model of trabecular bone and its application in deep learning prediction of bone fractures, and prediction/prevention of bone fragility fractures. I have been serving as PI for multiple NIH (R03, R21s, and R01s) and NSF supported projects.Diseases Associated: Osteoporosis, osteopenia, osteogenesis imperfecta, diabetes.
  Techniques Used: MicroCT, synchrotron X-ray scattering, Light and confocal microscopy, FTIR, Raman spectroscopy. SEM, TEM, AFM, NMR/MRI, DXA, HPLC, Mechanical testing

• Publications

  Xiaodu Wang, Haoran Xu, Yehong Huang, Sumin Gu, and Jean Jiang: Coupling effect of water and proteoglycan on the in situ toughness of bone, JBMR, (2016) 31(5): 1026-1029.

  Liqiang Lin, Jitin Samuel, Xiaodu Wang, and Xiaowei Zeng: Contribution of extrafibrillar matrix to the mechanical behavior of bone using a novel cohesive finite element model, Journal of Mechanical Behavior of Biomedical Materials, (2016) 65: 224-235.

  Xiao Yang, Ahmed Jenan Mostafa, Mark Appleford, Lian-Wen Sun, and Xiaodu Wang: Bone formation is affected by matrix advanced glycation end products (AGEs) in vivo, Calcified Tissue International, (2016) 99(4): 373-383

  X. Dong, H. Leng, Q. Ran, X. Wang: Finding of microdamage morphology differences in mice femoral bones with distinct mineralization levels, Journal of Mechanics in Medicine and Biology (2010) accepted.

  Silva, M. J., Brodt, M. D., Lynch, M. A., McKenzie, J. A., Tanouye, K. M., Nyman, J. S., Wang, X: Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life, Journal of bone and mineral research, 24 (2009) 1618-27

  X. Dong, T. Guda, H.R. Millwater, X. Wang: Probabilistic prediction of microdamage progression in bone using a finite element model of mineral-collagen composites, J. Biomech. 42 (2009) 202-209.

  Y. Yang, S. Park, Y. Liu, K. Lee, H. Kim, J. Koh, X. Meng, K. Kim, H. Ji, X. Wang, J. Ong: Development of sputtered nanoscale titanium oxide coating on osseointegrated implant devices and their biological evaluation, Vacuum 83 (2009) 569-574.

  H. Leng, X. Dong, and X. Wang: Progressive post-yield behavior of human cortical bone in compression for middle-aged and elderly groups, J. Biomech. 42 (2009) 491-497

  J.S. Nyman, H. Leng, X. Dong, X. Wang: Differences in the mechanical behavior of cortical bone between compression and tension when subjected to progressive loading, Journal of Mechanical Behavior of Biomaterials, 2 (2009) 613-619

  J.S. Nyman; Q. Ni, D.P. Nicollela, X. Wang: Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone, Bone 42 (2008) 193–199.

  X. Wang, J.S. Nyman: A novel approach to assess post-yield energy dissipation of bone in tension, J. Biomech. 40 (2007) 674-7.

  X. Wang, Y.J. Yoon, & H. Ji: A novel scratching approach for measuring age-related changes in the in situ toughness of bone, J. Biomech. 40 (2007) 1401-4.

  S. Parachuru, A Jain, and X. Wang: Size requirements of compact sandwich specimen for testing of bone, J. Mechanics in Medicine and Biology 7 (2007) 419-431

  J.S. Hyman, A. Roy, J.H. Tyler, R. Acuna, H.J. Gayle, and X. Wang: Age-related factors affecting the post-yield energy dissipation of human cortical bone. J. Orhtop. Res. 25 (2007) 646-655.

  Q. Ni, J. S. Nyman, X. Wang, A. De Los Santos, and D.P. Nicolella: Assessment of water distribution changes in human cortical bone by nuclear magnetic resonance，Meas. Sci. Technol. 18 (2007) 1–9.

  J.S. Nyman, A. Roy, R.L. Acuna, H.J. Gayle, M.J. R eyes, J.H. Tyler, D.D. Dean, and X. Wang: Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue, Bone, 39 (2006) 1210-1217.

  J.G. Fleischli, T.J. Laughlin, K.A. Athanasiou, D.R. Lanctot, L. Lavery, X. Wang, and C.M. Mauli: Effect of diabetes mellitus on the material properties of the distal tibia. Journal of the American Podiatric Association, (2006) 96(2) 91-95.

  J. Nyman, A. Roy, X. Shen, and X. Wang: The influence of water distribution on the strength and toughness of cortical bone, J. Biomech. (2006) 39(5) 931–938.