Jing Yong Ye, Ph.D.

Biophotonics, Bioimaging, Biosensing, Cancer diagnosis, Drug delivery, Neuroengineering Research

Dr. Jing Yong Ye’s research is focused on biophotonics and nanobiotechnology. He has developed a number of innovative technologies for biomedical imaging and sensing applications and holds 14 patents. He has invented and developed a unique label-free biosensor by utilizing photonic crystal structures in a total-internal-reflection configuration, which has been demonstrated for a wide range of applications. For instance, the biosensor is highly sensitive in the detection of cardiac biomarkers for potential rapid diagnosis of myocardial infarction. Dr. Ye has also been working with his collaborators with a major grant from USDA to screen different peptides for the treatment of a serious soybean plant disease. Moreover, he has developed an innovative approach for sensitive detection of endotoxin that has great potential to be utilized by pharmaceutical industry for quality control of parenteral pharmaceuticals and implantable medical devices. His new approach has improved the assay sensitivity of endotoxin by 200 times compared to the best commercially available systems and reduced the time needed for the assay by more than half. Recently, supported by two NIH grants, Dr. Ye and his collaborators have been working on developing new techniques for prostate cancer detection as well as for drug screening of cardiotoxicity by utilizing a label-free biosensor in conjunction with a heart-on-a-chip. In addition, Dr. Ye has been working on photoacoustic tomography for cancer diagnosis and brain imaging, fluorescence biosensing/imaging based on a patented double-clad fiber, as well as nanoparticle-based drug delivery system for enhanced treatment of cancer.   

Associated Diseases: Breast Cancer, Prostate Cancer, Neurodegenerative diseases

Techniques Used: Label-free biosensing, Photoacoustic imaging, Fiber-based fluorescence biosensing

• Research & Grants

   

   

   

• Publications

  Bailin Zhang, Bing Wang, Andres W. Morales, Jonathan Scudder, Madan K. Bhattacharyya, and Jing Yong Ye “Study of the Interactions of Fusarium virguliforme Toxin FvTox1 with Synthetic Peptides by Molecular Simulations and a Label-Free Biosensor”, Analytical Chemistry 88, 3024-30 (2016).

  He Huang, Gilbert Bustamante, Ralph Peterson, and Jing Yong Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction”, Medical Physics 42, 2169-2178 (2015).

  Bailin Zhang; Andres Morales, Ralph Peterson; Liang Tang, and Jing Yong Ye, “Label-free Detection of Cardiac Troponin I with a Photonic Crystal Biosensor”, Biosensors and Bioelectronics, 58C, 107-113 (2014).

  Ralph Peterson, Steven Solis, Bailin Zhang, He Huang, and Jing Yong Ye, “Sensitivity Enhancement of an Open Cavity Based Optoacoustic Sensor”, Optics Letters, Vol. 38, 2739-2741 (2013).

  Bailin Zhang, Juan Manuel Tamez-Vela, Steven Solis, Gilbert Bustamante, Ralph Peterson, Shafiqur Rahman, Andres Morales, Liang Tang and Jing Yong Ye, “Detection of Myoglobin with open-cavity and label-free photonic crystal biosensor”, Journal of Medical Engineering, 808056, 2013.

  Bailin Zhang, Chia-Yi Fang, Cheng-Chun Chang, Ralph Peterson, Saher Maswadi, Randolph D. Glickman, Huan-Cheng Chang, and Jing Yong Ye, “Photoacoustic Emission from Fluorescent Nanodiamonds Enhanced with Gold Nanoparticles”, Biomedical Optics Express 3, 1662–1629 (2012).

  Shatha Dallo, Bailin Zhang, James Denno, Soonbae Hong, Anyu Tsai, Williams Haskins, Jing Yong Ye, and Tao Weitao, “Association of Acinetobacter baumannii EF-Tu with cell surface, outer membrane vesicles and fibronectin”, the Scientific World Journal, Vol. 2012, 127805 (2012)

  Thommey P. Thomas, Yu-Chung Chang, Jing Yong Ye, Alina Kotlyar, Zhengyi Cao, Rameshwer Shukla, Suyang Qin, Theodore B. Norris, James R. Baker Jr., “Optical fiber-based in vivo quantification of growth factor receptors”, Cancer, 118, 2148-56 (2012).

  Yun Zhou, Kun Yang, Jianmin Cui, Jing Yong Ye, Cheri X. Deng, “Controlled permeation of cell membrane by single bubble acoustic cavitation”, J. of Controlled Release, 157, 103-111, (2012).

  Bailin Zhang, Shatha Dallo, Ralph Peterson, Syed Hussain, Tao Weitao, and Jing Yong Ye “Detection of anthrax lef with DNA-based photonic crystal sensors”, Journal of Biomedical Optics 16, 127006 (2011).

  Colin M. Chow, Yun Zhou, Yunbo Guo, Theodore Norris, Xueding Wang, Cheri Deng, and Jing Yong Ye, “Optical Ultrasound Sensor with a Unique Open-Cavity Structure”, J. Biomed. Opt. 16, 017001 (2011).

  Christine Tse, Marwa J Zohdy, Jing Yong Ye, Matthew O'Donnell, Wojciech Lesniak and Lajos Balogh, “Enhanced optical breakdown in KB cells labeled with folate-targeted silver-dendrimer composite nanodevices”, Nanomed Nanotechnol Biol. Med., 7, 97-106 (2011)

  Yunbo Guo, Jing Yong Ye, Charles Divin, Baohua Huang, Thommey P. Thomas, James R. Baker, Jr. and Theodore B. Norris, “Real-Time Biomolecular Binding Detection Using a Sensitive Photonic Crystal Biosensor”, Anal. Chem., 82, 5211-5218 (2010).