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Graduate School of Biomedical Sciences, UT Health San AntonioGraduate School of Biomedical Sciences, UT Health San Antonio

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  • Yogesh Gupta, PhD
Yogesh_gupta

Contact

210-562-9064

guptay@uthscsa.edu

Programs

Biochemical Mechanisms in Medicine
Cancer Biology
Molecular Immunology & Microbiology
Ph.D. in Integrated Biomedical Sciences

Departments & Divisions

Department of Biochemistry & Structural Biology

Institutes and Centers

  • Greehey Children’s Cancer Research Institute

Research

Gupta Lab

Currently seeking Ph.D. students.

Yogesh Gupta, Ph.D.

Assistant Professor

Gupta Lab Expertise:

  • Structural Biology
  • Epigenetic Mechanisms
  • Leukemia
  • Drug Discovery

Our studies seek to provide a complete and coherent picture of human mRNA modification complexes at the molecular and atomic level with a final goal to develop novel anticancer therapeutics targeting the RNA methylome and other nucleoprotein assemblies. We employ leading-edge structural biology methods such as X-ray crystallography, NMR, SAXS, EM in combination with an array of other biophysical and chemical biology tools to elucidate structures and mechanisms of macromolecular complexes central to childhood malignancies.

Related Diseases: Pediatric cancers

Techniques:  X-ray crystallography, NMR spectroscopy, small-angle X-ray scattering (SAXS) and other solution biophysics methods

  • Research & Grants

    Lab Research

    We are particularly interested in understanding the exact mechanisms by which different enzymes and accessory factors cross-talk, assemble, and install various covalent chemical modifications on both coding and noncoding RNAs. N6-methyladenosine (m6A) is the most prevalent form of internal post-transcriptional modifications in human mRNAs. The m6A associated complexes drive cellular transformation and sustained oncogenic translation in cancer. A complete structural elucidation of m6A sub-complexes would facilitate the designing of therapeutic strategies to target the dysregulated human RNA methylome in cancer selectively.  

    Gupta Lab

    Grants

    • Dr. Gupta's Grants
  • Publications

    • Dr. Gupta's NCBI Bibliography

Related media

  • Gupta Lab News & Events
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UT Health San Antonio
Graduate School of Biomedical Sciences

7703 Floyd Curl Drive

San Antonio, TX 78229

210-567-3709

gsbs@uthscsa.edu

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