Kenneth M. Hargreaves, D.D.S., Ph.D.

Dr. Hargreaves received his B.A. in neurobiology from the University of California at Berkeley in 1977, his D.D.S. from Georgetown University in Washington, D.C., in 1983, and his Ph.D. in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in 1986.

From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently professor and chair of the Department of Endodontics, and professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at UT Health San Antonio. He also maintains a private practice limited to endodontics.

• Professional Background

  Education

  • 1993 - Postdoctoral Training - Endodontics - University of Minnesota, School of Dentistry
  • 1990 - Postdoctoral Fellowship - Sr Staff Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
  • 1988 - Postdoctoral Fellowship - Postdoc Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
  • 1986 - PhD - Physiology - Uniformed Services University of the Health Sciences
  • 1985 - Postdoctoral Fellowship - NRSA Postdoc Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
  • 1983 - DDS - Dentistry - Georgetown University
  • 1977 - BA - Neurobiology - University of California at Berkeley
  • 1977 - BA - Neurobiology - University of California at Berkeley
  • Predoc Research Fellow, School of Dentistry - Georgetown University

  Highlights

  Diplomate, American Board of Endodontics

  President’s Award, American Association of Endodontists (2020)

  ADA Research Gold Medal Award (2018)

  President’s Distinguished Senior Scholar Award (2013; Highest University Faculty Honor)

  AAE Louis I. Grossman Award for Research (2007)

  IADR Distinguished Scientist Awards (1999 & 2000), AADR Senior Scholar Award in Neuroscience (2017)

  NIH MERIT Award (1999)

   

   

   

  Appointments

  • 12/2015 - COSTAR Director - University of Texas Health Science Center at San AntonioSan Antonio
  • 3/2007 - Professor - University of Texas Health Science Center at San Antonio, Surgery, San Antonio
  • 3/2007 - Professor - University of Texas Health Science Center at San Antonio, Physiology, San Antonio
  • 9/2005 - President`s Council Chair in Dental Research Endowment - University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio
  • 1/2003 - Editor-in-Chief - Journal of Endodontics, official journal of the American Association of Endodontists
  • 7/1997 - Professor - University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio
  • 7/1997 - Professor and Chair and Department Chair - University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio
  • 5/1990 - Associate Professor - University of Minnesota School of Dentistry

• Instruction & Training

  • 1/2015 - Present, Ph.D. Dissertations Directed, University of Texas Health Science Center at San Antonio
  • 1/2014 - Present, Masters' Thesis Directed, University of Texas Health Science Center at San Antonio
  • 1/2014 - Present, Ph.D. Dissertations Directed, University of Texas Health Science Center at San Antonio
  • 9/2011 - Present, Ph.D. Dissertations Directed, PhD Program in Pharmacology, UTHSCSA
  • 4/2011 - Present, Pharmacology, The University of Texas Health Science Center
  • 1/2010 - Present, Membership on Supervising Committee, Physiology, UTHSCSA
  • 8/2008 - Present, Fundamentals of Neuroscience II, The University of Texas Health Science Center
  • 1/2008 - Present, Graduate (Adv Education in Endodontics), The University of Texas Health Science Center
  • 7/1999 - Present, Endodontics Clinic, The University of Texas Health Science Center
  • 1/1999 - Present, Clinical Endodontics I, The University of Texas Health Science Center
  • 1/1999 - Present, Clinical Endodontics, The University of Texas Health Science Center
  • 1/1999 - Present, Core Course Oral Biology (Dental Biomedical Core II), The University of Texas Health Science Center
  • 1/1999 - Present, Clinical Endo II, The University of Texas Health Science Center
  • 1/1999 - Present, Clinical Endodontics II, The University of Texas Health Science Center
  • 1/1999 - Present, Clinical Endo II, The University of Texas Health Science Center
  • 1/1999 - Present, ENDO5011 Clinical Endodontics I, The University of Texas Health Science Center
  • 7/1998 - Present, Endodontics Seminar, The University of Texas Health Science Center
  • 7/1998 - Present, Neuropsychopharmacology
  • 1/1998 - Present, Endodontics Clinic, The University of Texas Health Science Center
  • 1/1998 - Present, Clinical Endodontics
  • 1/1998 - Present, Graduate Endodontics
  • 1/1998 - Present, Sophomore Endodontics
  • 1/1998 - Present, Periodontal Topics
  • 1/1998 - Present, Clinical Seminar I, The University of Texas Health Science Center
  • 1/1998 - Present, Endodontics Lecture, The University of Texas Health Science Center
  • 9/1997 - Present, Endodontics Lecture, The University of Texas Health Science Center
  • 1/1997 - Present, Junior Endodontics

• Research & Grants

  Pain mechanisms and development of novel analgesics

  Experimental and Developmental Therapeutics Program

  Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics

  Primary research interests are in the areas of pain and inflammation. Ken's ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures.

  Research profile

  Grants

  Federal

  Source: NIH R01 NS110948

  Title: Mechanisms for Omega-6 Modulation of Primary Afferent Nociceptors

  Period:  2019-2024

  Reqiuested Total Costs: Current Year/Total Direct:  $250,000 / $1,250,000

  Role:     Principal Investigator

   

  Source: NIH R01 DE26139

  Title: Regulation of TRPV1 activities by a sexually dimorphic mechanism

  Period:  2016-21

  Reqiuested Direct Costs: Current Year/Total Direct:  $250,000 / $1,250,000

  Role:     Principal Investigator

   

  Source: Dept of Defense Contract #W81XWH-15-1-0129

  Title: Developing novel analgesics for treating burn pain

  Period:  2015-19

  Direct Costs: Current Year/Total Direct:  $321,887 / $965,662

  Role:     Principal Investigator 

   

  Source: American Association of Endodontists Foundation

  Title: Regeneration of pulp-dentin development in teeth with necrotic pulps

  Period:  2013-21

  Direct Costs: Current Year/Total Direct:  $283,333/$1,700,000

  Role:     Principal Investigator 

   

  Source: NIH, NCATS UL1TR001120 (UTHSCSA CTSA Application)

  Title:  Institute for Integration of Medicine & Science: A Partnership to Improve Health

  Period:  2018-2023

  Direct Costs: Current Year/Total Direct:  $4,324,613/$21,623,065

  Role:     Co-Principal Investigator  (Co-PIs: Robert Clark, Don Dougherty, Ken Hargreaves and Paula Shireman)

   

  Source: NIDCR T32 DE14318

  Title:  CO*STAR Training Grant

  Period:  2018-2023 

  Direct Costs: Current Year/Total Direct:  $171,791/$858,955

  Role:  CO*STAR Program Director and Director of DDS/PhD track

  Private

  Funding Agency USAA Foundation Title New Method to Treat Burn Pain in Our Wounded Warriors Status Active Period 6/2010 - 1/2029 Role Principal Investigator Grant Detail   Funding Agency Barker Foundation Title Pain Management Status Active Period 1/2013 - 1/2018 Role Principal Investigator Grant Detail  

   

  Funding Agency American Association for Endodontists Foundation Title Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots Status Active Period 1/2013 - 1/2019 Role Principal Investigator Grant Detail PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves.
  This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics.

• Publications

  • NLM Link for Ken Hargreaves Publications
  • Google Scholar for Ken Hargreaves

• Clinical

  Endodontist

  Board Certifications

  • 1999 - American Board of Endodontics

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