Tim Hui-Ming  Huang, Ph.D.

Dr. Tim Huang's lab has been conducting epigenetic/genetic analyses of cancer for the last twenty-nine years and has pioneered the development of high-throughput microarray and next-generation sequencing technologies for integrative analysis of cancer genomes. These omics approaches are used in combination with statistical and bioinformatic tools to develop biological models of tumor progression.

More recently, our research team has developed novel technologies to characterize single cancer cells and to address intra-tumor heterogeneity in prostate cancer patients. These novel technologies include isolation of single prostate tumor cells from blood and urine samples, single-cell expression profiling with microfluidic devices, and single-cell topographical analysis using atomic force microscopy.  

The novel technologies will now be used for early detection and for identifying prostate cancer patients who are at risk of advanced development.

Related Diseases: Breast, prostate, lung and endometrial cancers.

Techniques: Single-cell genomics and omics.

• Research & Grants

  Dr. Tim Huang's lab has been conducting epigenetic/genetic analyses of cancer for the last twenty nine years and has pioneered the development of high-throughput microarray and next-generation sequencing technologies for integrative analysis of cancer genomes. These omics approaches are used in combination with statistical and bioinformatic tools to develop biological models of tumor progression. 

  Research profile

• Publications

  Hsu PY, Hsu HK, Lan X, Juan L, Yan PS, Labanowska J, Heerema N, Hsiao TH, Chiu YC, Chen Y, Liu Y, Li L, Li R, Thompson IM, Nephew KP, Sharp ZD, Kirma NB, Jin VX, Huang TH. Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer. Cancer Cell. 2013 Aug 12;24(2):197-212.

  Hsu YT, Gu F, Huang YW, Liu J, Ruan J, Huang RL, Wang CM, Chen CL, Jadhav RR, Lai HC, Mutch DG, Goodfellow PJ, Thompson IM, Kirma NB, Huang TH. Promoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer. Clin Cancer Res. 2013 Nov 15;19(22):6272-85. 

  Chen CL, Mahalingam D, Osmulski P, Jadhav RR, Wang CM, Leach RJ, Chang TC, Weitman SD, Kumar AP, Sun L, Gaczynska ME, Thompson IM, Huang TH. Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer. Prostate. 2013 Jun;73(8):813-26.

   

  Please click here for Dr. Huang's NIH bibliography.