Part of UT Health San Antonio

 

You are here

javors_m

Contact

210-567-5532

javors@uthscsa.edu

Programs

Biology of Aging
M.S. in Clinical Investigation & Translational Science
Ph.D. in Integrated Biomedical Sciences
Physiology and Pharmacology

Departments & Divisions

Department of Psychiatry & Behavioral Sciences

Martin A  Javors, Ph.D.

Professor (Tenured)

Departments of Psychiatry and Pharmacology

Dr. Javors is a Professor in the Division of Alcohol and Drug Addiction at The University of Texas Health Science Center at San Antonio (UTHSCSA) and an active collaborator on projects within the Neurobehavioral Research Division. Dr. Javors is director of the Biological Psychiatry Analytical Laboratory, which is located in the Department of Psychiatry at UTHSC. The BPAL provides a wide variety of biochemical measurements related to psychiatric research. Dr. Javors has been an active collaborator on many of the NRLC studies. Much of this work involves characterization of serotonin function and its relationship to impulsivity among the various clinical groups we work with. 

Research Interests

  • Biochemical markers of alcohol consumption
  • Biochemical markers of nicotine use
  • Serotonin, dopamine and norepinephrine transporters
  • Measurement of catecholamines in various tissues
  • Membrane transducing systems
  • Second messenger function of Ca2+
  • Development of analytical tests for psychotherapeutic drugs

  • Professional Background

    Education

    • 1979 - PharmD - Pharmacy (Pharmacology) - University of Colorado at Boulder
    • 1967 - BS - Pharmacy - University of Texas at Austin
    • Postdoctoral Fellowship - Pharmacology - University of Texas Health Science Center at San Antonio

    Appointments

    • 1/1999 - Adjunct Professor - University of Texas at Austin, College of Pharmacy, Pharmacology, Austin
    • 1/1999 - Professor with tenure and Director of the Biological Psychiatry Analytical Labs - University of Texas Health Science Center at San Antonio, Psychiatry and Pharmacology, San Antonio

  • Instruction & Training

    • - Present, Ph.D. Dissertations Directed, University of Texas at Austin
    • - Present, Ph.D. Dissertations Directed, UTHSCSA
    • 6/2002 - Present, Post-Doctoral Student Supervision, UTHSCSA
    • 1/1988 - Present, UTHSCSA

  • Research & Grants

    Grants

    Federal

    Funding Agency
    Veterans Administration Hospital

    Title
    Technical Services for Psychotherapeutic Drug Levels

    Status
    Active

    Period
    6/1996 - Present

    Role
    Co-Investigator

    Grant Detail
    Director of Contract

    Funding Agency
    NIH

    Title
    Characterization of leptin`s antidepressant activity

    Status
    Active

    Period
    9/2012 - 7/2017

    Role
    Co-Investigator

    Grant Detail
    The aim of this proposal is to determine the neural mechanisms of leptin`s antidepressant effects.

    Funding Agency
    Institute of Alcohol Abuse and Alcoholism

    Title
    Phosphatidylethanol and Other Ethanol Consumption Markers

    Status
    Active

    Period
    9/2013 - 6/2017

    Role
    Co-Principal Investigator

    Grant Detail
    This study is designed to characterize and validate phosphatidylethanol as a biomarker for alcohol consumption and then determine how it alone (and in combination with 3 other alcohol biomarkers) can be used to identify an individual's level and pattern of drinking

    State

    Funding Agency
    University Hospital

    Title
    Technical Services for Psychotherapeutic Drug Levels

    Status
    Active

    Period
    1/1994 - Present

    Role
    Co-Investigator

    Grant Detail
    Director of Contract

     

    Funding Agency
    NIA

    Title
    Bioanalytical Pharmacology Core, Nathan Shcok Center, Barshop Institute

    Status
    Active

    Period
    6/2015 - 6/2020

    Role
    Principal Investigator

    Grant Detail
    The purpose of the center is to provide analytical support to research groups for aging studies. Measurement of drug levels in dosage forms (usually food) and animal blood and tissues is provided in addition to assistance with study design is offered

  • Publications

    Abstract

    Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright T, Dougherty DM. Pharmacokinetics of PETH 16:0/18:1 and 16:0/18:2 in human blood after 0.4 and 0.8 g/kg of alcohol in a clinical lab study: Presented at the Annual TRSA Meeting, UT-Pan Am Medical School, Edinburg, TX; 2017 Jan.
    Roache JD, Hill-Kapturczak N, Wright T, Lopez-Cruzan M, Dougherty DM, Javors MA. PETH 16:0/18:1, PETH 16:0/18:2, and the ratio of PEth 16:0/18:2 during a 2 week period of alcohol abstinence: Presented at the RSA annual meeting, Denver, Colorado; 2017 Jan.
    Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright T, Lopez-Cruzan M, Dougherty DM. The Pharmacokinetics of PETH 16:0/18:1 and 16:0/18:2 in human blood after 0.4 and 0.8 g/kg of alcohol in a clinical lab study: Presented at the RSA annual meeting, Denver, Colorado; 2017 Jan.
    Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright T, Dougherty DM. Characterization of the pharmacokinetics of phosphatidylethanol 16:0/18:1 and 16:0/18:2 in human whole blood after alcohol consumption in a clinical lab study: Presented at the Annual RSA Meeting, New Orleans, LA; 2016 Jan.
    Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright T, Dougherty DM. The Characterization of the pharmacokinetics of phosphatidylenthanol 16:0/18:1 and 16:0/18:2 in human whole blood after alcohol consumption in a clinical lab study: BBC Meeting San Antonio Texas; 2016 Jan.
    Javors MA, Hill-Kapturczak N, Karns T, Cates S, Roache JD, Dougherty DM. Are we ready to combine PETH with other biomarkers for alcohol consumption for use in general medical practice?: Presented at the annual TRSA meeting Texas A&M College Station TX; 2015 Jan.
    Javors MA, Hill-Kapturczak N, Sanchez JJ, Friesenhahn GS, ROache JD, Dougherty DM. Human lab study to characterize the relationship of the biomarker phosphatidylethanol and ethanol intake: Presented at the RSA Annual Meeting, San Antonio TX; 2015 Jan.
    Ginsburg BC, Hruba L, Zaki A, Javors MA, McMahon LA. Blood levels do not predict behavioral or physiological effects of 9-tetrahydrocannabinol in rhesus monkeys with different patterns of exposure.[in press]: Presented at the TRSA Annual Meeting, San Antonio Texas; 2014 Jan. (Drug and Alcohol Dependence).
    Javors MA, Hill-Kapturczak N, Roache JD, Lake SL, Dougherty DM. Comparison of dried blood spot versus thawed blood samples for validation of a phosphatidylethanol bioanalytical assay using HPLC/MS/MS: Presented at the Annual RSA Meeting Bellevue Washington; 2014 Jan.
    Livi C, Hsu H, Feliers D, Christy B, Dodds S, Javors MA, Strong J, Hasty E, Sharp Z. Prevention of Intestinal Plyps by a New Rapamycin Enteric Formulation: An Update: CPRIT Meeting; 2013 Oct. (Abstract 402).
    Javors MA, Hruba L, McMahon L. Pharmacokinetics of Delta9-tetrahydrocannabinol in rhesus monkeys and humans: relevance to legalization of marijuana for recreational use: BBC Meeting San Antonio Texas; 2013 Jan.
    Seneviratne, C, Javors MA, Roache JD, Dawes MA, Tiouririne NA, Johnson BA. Influence of current drinking on the expression of platelet serotonin transporters across allelic variants of 5?-HTTLPR in treatment seeking adult alcoholics: Presented at the RSA Annual Meeting, Santa Barbara, CA; 2005 Jan. (Alcoholism: Clinical and Experimental Research).

    Book Chapter

    Javors MA, King TS, Ginsburg BC, Collins GT, and Gerak LR. "Neurobehavioral Toxicology of Substances of Abuse". In: BA Johnson. Addiction Medicine, Science and Practice 2nd Edition. New York, In Press: Springer; 2017.

    Journal Article

    Ye W, Pitlock MD, Javors MA, Thompson B, Lechleiter JD, Hensler JG. The long-term effect of maternal dietary protein restriction on 5-HT receptor function and behavioral responses to stress in adulthood Behavioural Brain Research 2018 Jun;349:116-124.
    Fang Y, Hill CM, Darcy J, Reyes-Ordonez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun L, Chen J, Bartke A. Effects of Rapamycin on Growth Hormone Receptor Knockout Mice PNAS 2018 Feb;.
    Javors MA, Eric Schon. Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome Human Molecular Genetics 2017 Dec;.
    McDOnell MG, Skalisky J, Leickly E, Orr MF, McPherson S, Roll J, Hill-Kapturczak N, Javors MA. A pilot investigation of a phosphatidylethanol-based contingency management intervention targeting alcohol use Psychology of Addictive Behaviors, In Press 2017 May;.
    Moerke MJ, Zhu AZ, Tyndale RF, Javors MA, McMahon LR. The discriminative stimulus effects of intravenous nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-B-erythroidine Neuropharmacology 2017 Jan;116:9-17.
    Adinoff B, Leonard D, Price J, Javors MA, Walker R, Brown ES, Xiao H, Rao U. Adrenocortical sensitivity,moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men Psychoneuroendocrinology 2017 Jan;76:67-76.
    Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel M, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalh?es JP, McCord JM, Miller BF, Muller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Nadon NL, Harrison DE. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer Aging Cell 2016 Jul;15(5):872-884.
    Dodds S, Livi CB, Parihar, M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Adaptations to chronic rapamycin in mice Pathobiology of Aging & Age-realted Diseases 2016 May;6.
    Collins GT, Gerak LR, Javors MA, France CP. Lorcaserin reduces the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys Journal of Pharmacology and Experimental Therapeutics 2016 Jan;356(1):85-95.
    Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Choudhury GG, Hubbard GB, Barnes JL, Richardson A, Kasinath BS. Rapamycin increases mortality in db/db mice, a mouse model of type-2 diabetes J Gerontol A Biol Sci Med Sci 2016 Jan;71:850-857.
    Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright TE, and Dougherty DM. Characterization of the pharmacokinetics of phosphatidylethanol 16:0/18:1 and 16:0/18:2 in human whole blood after alcohol consumption in a clinical laboratory study Alcoholism Clinical and Experimental Research 2016 Jan;:1-7.
    Hahn J, Anton RF, Javors MA. The formation, elimination, interpretation and future research needs of phosphatieylethanol for research studies and clinical practice Alcoholism: Clinical and Experimental Research 2016 Jan;40:2292-2295.
    Thompson PM, Hill-Kapturczak N, Lopez-Cruzan M, Alvarado LA, Dwivedi AK, Javors MA. Phosphatidyletehanol in postmortem brain and serum ethanol at time of death Alcoholism: Clinical & Experimental Research 2016 Jan;40:2557-2562.
    Cunningham CS, Moerke MJ, Javors MA, Carroll FI, McMahon LR. Attenuated nicotine-like effects of varenicline but not other nAChR agonists in monkeys receiving nicotine daily Br J Pharmacol 2016 Jan;173:3454-3466.
    Laberge R-M, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, Curran S, Davalos A, Wilson-Edell K, Liu S, Limbad C, Demaria M, Li P, Hubbard G, Ikeno Y, Javors M, Desprez P-Y, Benz C, Kapahi P, Nelson P, Campisi J. mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL 1A translation Nat Cell Biol 2015 Aug;17(8):1049-1061.
    Paredes R, Piccart E, Navaira E, Cruz D, Javors MA, Koek W, Beckstand M, Walss-Bass C. Physiological and behavioral effects of amphetamine in BACE1-/-mice Genes, Brain and Behavior 2015 Jan;14:411-418.
    Zhang WQ, Smolik CM, Barba-Escobedo, PA, Gamez M, Sanchez JJ, Javors MA, Daws LC and Gould GG. Acute Dietary Tryptophan Manipulation Differentially Alters Social Behavior, Brain Serotonin and Plasma Corticosterone in Three Inbred Mouse Strains Neuropharmacology 2014 Nov;90(10):1-8.
    Murrell, Meredith, Cruz DA, Javors MA, Thompson PM. Distribution of venlafaxine, O-desmethylvenlafaxine, and O-desmethylvenlafaxine to venlafaxine ratio in postmortem human brain tissue Journal of Forensic Sciences 2014 May;59:683-689.
    Zhang Y, Bokov, Alex, Gelfond JA, Soto, V, Ikeno Y, Hubbard GB, Diaz, V, Sloane, L, Maslin, K, Treaster, S, Rendon, S, Ward WF, Javors MA, Van Remmen H, Richardson AG, Austad SN, Fischer K. Rapamycin Extends Life and Health in C57BL/6 Mice J Gerontol A Biol Sci Med Sci 2014 Feb;:119-130.
    Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Perez VI, Richardson A. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome PLoS One 2014 Jan;.
    Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Z. Dave Sharp, Van Roekel S, Winkleman L, Strong R. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction Aging Cell 2014 Jan;13(3):468-477.
    Blanchard OL, Friesenhahn G, Javors MA, Smoliga JM. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept PLoS One 2014 Jan;9.
    Hasty P, Livi C, Dodds S, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD, and Fischer K. eRapa Restores A Normal Life Span in a FAP Mouse Model Cancer Prev Res (Phila) 2014 Jan;7(1):169-178.
    Harrison DE, *Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey F, Javors MA, Nadon NL, Nelson JF, Simpkins JW, Smith D, Wilkinson JE, *Miller RA. Acarbose, 17-i?!-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males Aging Cell 2014 Jan;13:273-282.
    Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Perez VI. Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver Aging Cell 2013 Dec;13:311-319.
    Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors Aging (Albany NY) 2013 Feb;5(2):100-110.
    Johnson BA, Ait-Daoud N, Wang XQ, Penberthy JK, Javors MA, Seneviratne C, Liu L. Topiramate for the treatment of cocaine addiction Journal of the American Medical Association 2013 Jan;70:1338-1346.
    *Strong R., *Miller R.A., Astle, C.M., Baur, J.A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J.L., Nelson, J.F., Sinclair, D.A., Teter, B., Williams, D., Zaveri, N., Nadon, N.L., *Harrison, D.E. (*These authors contributed equally). Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium chain triglyceride oil on lifespan of genetically heterogeneous mice J Gerontol A Biol Sci Med Sci 2013 Jan;68:6-16.
    Lin A, Halloran JJ, Burbank RR, Korde S, Zheng W, Hussong SA, Podlutskaya N, Strong R, Richardson A, Hart MJ, Javors MA, Fox PT, Lechleiter J, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer?s disease J Cereb Blood Flow Metab 2013 Jan;33:1412-1421.
    Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, Wang F, Javors MA, Chen J, Sun LY, Bartke A. Duration of rapamycin treatment has differential effects on metabolism in mice Cell Metabolism 2013 Jan;17:456-462.
    King TS, Toney GM, Tian PY and Javors, MA. Dehydration Increases Sodium Dependent Glutamate Uptake by Hypothalamic Paraventricular Nucleus Synaptosomes Neuroendocrinology Letters 2011 Mar;32(6):763-768.
    Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201.
    Javors MA, Hatch JP, Lamb RJ. Sequential combination of self-report, breath carbon monoxide, and saliva cotinine to assess smoking status Drug Alcohol Depend 2011 Jan;113(2-3):242-244.
    Ginsburg BC, Javors MA, Friesenhahn G, Frontz M, Martinez G, Hite T, Lamb RJ. Mouse breathalyzer Alcoholism: Clinical and Experimental Research 2008 Jul;32(7):1181-1185.
    Lamb RJ, Morral AR, Kirby KC, Javors MA, Galbicka G, Iguchi M. Contingencies for change in complacent smokers Exp Clin Psychopharmacol 2007 Jun;15(3):245-255.

    Not Specified

    Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOr drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment J Cereb Blood Flow Metab 2018 Jan;38(1):58-74.