Xueqiu Jian, PhD

Research lies in the genetic epidemiology of human complex traits related to brain aging, with the focus on identifying genetic risk factors and underlying mechanisms contributing to Alzheimer’s disease and related endophenotypes using genomics and multi-omics approaches in large, representative human population samples. Actively involved in large national and international Alzheimer’s genomics projects, including genome-wide association meta-analyses, whole exome/genome sequencing analyses, etc., within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, the Alzheimer’s Disease Sequencing Project (ADSP), the Trans-Omics for Precision Medicine (TOPMed) program, and the International Genomics of Alzheimer’s Project (IGAP).

• Professional Background

  Education

  • 2014 - PhD - Public Health - University of Texas at Houston, Houston, TX
  • 2010 - MPH - Epidemiology - East Tennessee State University, Johnson City, TN
  • 2008 - BM - Mediicine - Sun Yat-sen University, Guangzhou, China

  Highlights

  2019-2021     KL2 Scholar, Univeristy of Texas Health Science Center San Antonio

  2018  Travel Fellowship, Alzheimer's Association International Conference 

  2015-2016 Dean's Excellence in  Research Award, UTHSC Houston

  2012-2013 Reuel A. Stallones MEmorial Scholarship, UTHSC Houston

  2011 Tuition and Travel Scholarship, University of Washington in Settle, WA

  2010-2011 New Student Scholarship, UTHSC Houston

   

   

   

• Research & Grants

  2014-2018       Postdoctoral Research Fellow, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX

  2010-2014       Graduate Research Assistant, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX

  2008-2010       Graduate Research Assistant, East Tennessee State University College of Public Health, Johnson City, TN

• Publications

  1. Sargurupremraj M*, Suzuki H*, Jian X*, Sarnowski C*, Evans TE*, Bis JC*, et al (2020). Cerebral small vessel disease genomics and its implications across the lifespan. Nature Communications 11:6285. *Contributed equally.
  2. Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, et al (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications 11:4796.
  3. Bis JC*, Jian X*, Kunkle BW*, Chen Y*, et al (2020). Whole exome sequencing study identifies novel rare and common Alzheimer’s-associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry 25:1859-1875. *Contributed equally.
  4. Jian X, et al (2020). Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos. Translational Psychiatry 10:245.
  5. Shin J, Ma S, Hofer E, Patel Y, Vosberg DE, Tilley S, Roshchupkin GV, Sousa AMM, Jian X, et al (2020). Global and regional development of the human cerebral cortex: molecular architecture and occupational aptitudes. Cerebral Cortex 30(7):4121-4139.
  6. Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, et al (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics 51:1624-1636.
  7. Sun D, Tiedt S, Yu B, Jian X, et al (2019). A prospective study of serum metabolites and risk of ischemic stroke. Neurology 92(16):e1890-e1898.
  8. Mishra A, Chauhan G, Violleau MH, Vojinovic D, Jian X, et al (2019). Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain 142(4):1009-1023.
  9. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, et al (2019). Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51:414-430.
  10. Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, et al (2019). Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology 92(5):e486-e503.
  11. González HM, Tarraf W, Jian X, et al (2018). Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). Scientific Reports 8:17578.
  12. Vojinovic D, Adams HH, Jian X, et al (2018). Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications 9:3945.
  13. Jian X, et al (2018). Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain MRI. Stroke 49(8):1812-1819.
  14. Jian X, et al (2018). Imaging endophenotypes of stroke as a target for genetic studies. Stroke 49(6):1557-1562.
  15. Butkiewicz M, Blue E, Leung F, Jian X, et al (2018). Functional annotation of genomic variants in studies of late-onset Alzheimer's disease. Bioinformatics 34(16):2724-2731.
  16. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, et al (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics 50:524-537.
  17. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, et al (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics 49:1373-1384.
  18. Chauhan G, Arnold CR, Chu AY, Fornage M, Reyahi A, Bis JC, Havulinna AS, Sargurupremraj M, Smith AV, Adams HHH, Choi SH, Pulit SL, Trompet S, Garcia ME, Manichaikul A, Teumer A, Gustafsson S, Bartz TM, Bellenguez C, Vidal JS, Jian X, et al (2016). Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet Neurology 15(7):695-707.
  19. Dong C, Wei P, Jian X, et al (2015). Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies. Human Molecular Genetics 24(8):2125-2137.
  20. Jian X, et al (2014). In silico prediction of splice-altering single nucleotide variants in the human genome. Nucleic Acids Research 42(22):13534-13544.
  21. Jian X, et al (2014). In silico tools for splicing defect prediction: a survey from the viewpoint of end users. Genetics in Medicine 16:497-503.
  22. Liu X, Jian X, et al (2013). dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations. Human Mutation 34(9):E2393-E2402.