David Kadosh, Ph.D.

Microbiology, Molecular Biology and Molecular Genetics

Fungal Pathogenesis   Regulation of morphology, virulence and virulence-related properties in Candida species   Our research is focused is on molecular mechanisms that control fungal pathogenesis with an emphasis on Candida species, the 4th leading cause of hospital-acquired bloodstream infections in the U.S. A wide variety of immunocompromised individuals, including cancer patients, organ transplant recipients and AIDS patients, are susceptible to infection. We are particularly interested in transcriptional and translational mechanisms that control Candida albicans virulence and several key virulence-related properties, including morphogenesis, biofilm formation and antifungal resistance, in response to host environmental cues. We also carry out studies to determine how and why certain Candida species have evolved to become more pathogenic than others.   Related Diseases: Cancer, heart disease, AIDS, most immunosuppressive diseases   Techniques: Molecular biology, microbiology, molecular genetics, genomics, bioinformatics, cell biology, biochemistry   Visit Dr. David Kadosh's lab »  

• Professional Background

  Education

  • 1998 - PhD - Biological Chemistry & Molecular Pharmacology - Harvard University
  • 1991 - BA - Biological Sciences (Magna Cum Laude) - Cornell University
  • Postdoctoral Fellowship - Microbiology & Immunology - University of California, San Francisco

  Appointments

  • 9/2019 - Professor - University of Texas Health Science Center at San Antonio, Medicine, San Antonio
  • 9/2019 - Professor - University of Texas Health Science Center at San Antonio, Microbiology, Immunology, and Molecular Genetics, San Antonio

• Instruction & Training

  • 2/2019 - Present, Post-Doctoral Student Supervision, University of Texas Health Science Center at San Antonio
  • 9/2014 - Present, Pathogenic Microbiology, The University of Texas Health Science Center
  • 10/2013 - Present, Dental Biomed Core I, The University of Texas Health Science Center
  • 1/2013 - Present, Core Course II/Molecular Biology, The University of Texas Health Science Center
  • 5/2011 - Present, Masters' Thesis Directed, UTHSCSA
  • 5/2011 - Present, Membership on Supervising Committee, University of Texas Health Science Center at San Antonio
  • 6/2008 - Present, Eukaryotic Pathogens, University of Texas Health Science Center at San Antonio
  • 4/2008 - Present, Eukaryotic Pathogens, The University of Texas Health Science Center
  • 5/2007 - Present, Pre-Doctoral Student Supervision, University of Texas Health Science Center at San Antonio
  • 11/2006 - Present, Rotation Student Supervision, University of Texas Health Science Center at San Antonio
  • 9/2006 - Present, Membership on Supervising Committee, University of Texas Health Science Center at San Antonio

• Research & Grants

  Research profile

• Publications

  Book Chapter

  Kadosh D. Morphogenesis in C. albicans. In: Kadosh D. Candida albicans: Cellular and Molecular Biology II. 2017.

  Journal Article

  Romo JA
  Zhang H
  Cai H
  Kadosh D
  Koehler JR
  Saville SP
  Wang Y
  Lopez-Ribot JL. Global transcriptomic analysis of the Candida albicans response to treatment with a novel inhibitor of filamentation mSphere 2019 Jan;4(5). Banerjee M
  Lazzell AL
  Romo JA
  Lopez-Ribot, JL
  Kadosh D. Filamentation is associated with reduced pathogenicity in multiple non-albicans Candida species mSphere 2019 Jan;4(5). Vipulanandan, G., Herrera, M., Wiederhold, N.P., Li, X., Mintz, J., Wickes, B.L., and D. Kadosh. Dynamics of mixed-Candida species biofilms in response to antifungals J. Dent. Res 2018 Jan;97(1):91-98. Kadosh, D
  Najvar, LK
  Bocanegra, R
  Olivo, M
  Kirkpatrick, WR
  Wiederhold, N
  Patterson, T. Effect of antifungal treatment in a diet-based murine model of disseminated candidiasis acquired via the gastrointestinal tract Antimicrob Agents Chemother 2016 Jan;60:6703-6708. Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJ, Gow NA, MacCallum DM, Kolls JK, Brown GD. Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity Cell Microbiol 2015 Apr;17(4):445-450. Kadosh D. Filament condition-specific response elements control the expression of NRG1 and UME6, key transcriptional regulators of morphology and virulence in Candida albicans PLoS ONE 2015 Mar;10(3). Albataineh M, Lazzell A, Lopez-Ribot J, Kadosh D. Ppg1, a PP2A-type protein phosphatase, controls filament extension and virulence in Candida albicans Eukaryot Cell 2014 Dec;13(12):1538-1547. Childers, D.S, Mundodi, V., Banerjee, M., Kadosh D. A 5? UTR-mediated translational efficiency mechanism inhibits the Candida albicans morphological transition Mol Microbiol 2014 May;92(3):570-585. Lackey E, Vipulanandan G, Childers DS, Kadosh D. Comparative evolution of morphological regulatory functions in Candida species Eukaryot Cell 2013 Oct;12(10):1356-1368. Carlisle PL, Kadosh D. A genome-wide analysis of morphology determination in Candida albicans Mol Biol Cell 2013 Feb;24(3):246-260. Banerjee M, Uppuluri, P, Xhao XR, Carlisle PL, Vipulanandan G, Villar CC, Lopez-Ribot, JL, Kadosh D. Expression of UME6, a key regulator of Candida albicans hyphal development, enhances biofilm formation via Hgc1- and Sun41-dependent mechanisms Eukaryot Cell 2013 Feb;12(2):224-232. Carlisle, PL, Kadosh D. Candida albicans Ume6, a filament-specific transcriptional regulator, directs hyphal growth via a pathway involving Hgc1 cyclin-related protein Eukaryot Cell 2010 Sep;9(9):1320-1328. Uppuluri P, Chaturvedi AK, Srinivasan A, Banerjee M, Ramasubramaniam AK, Kohler JR, Kadosh D, Lopez-Ribot JL. Dispersion as an important step in the Candida albicans biofilm developmental cycle PLoS Pathog 2010 Mar;6(3). Carlisle PL, Banerjee M, Lazzell A, Monteagudo C, Lopez-Ribot JL, Kadosh D. Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence Proc Natl Acad Sci U S A 2009 Jan;106(2):599-604. Banerjee M, Thompson DS, Lazzell A, Carlisle PL, Pierce C, Monteagudo C, Lopez-Ribot JL, Kadosh D. UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence Mol Biol Cell 2008 Apr;19(4):1354-1365. Kadosh D, Johnson AD. Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis Mol Biol Cell 2005 Jun;16(6):2903-2912. Braun BR*, Kadosh D*, Johnson AD (*These two authors made equal contributions). NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction EMBO J 2001 Sep;20(17):4753-4761. Kadosh D, Johnson AD. Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans Mol Cell Biol 2001 Apr;21(7):2496-2505. Banerjee M
  Lazzell AL
  Romo JA
  Lopez-Ribot JL
  Kadosh D. Filamentation is associated with reduced pathogenicity of multiple non-albicans Candida species mSphere 2001 Feb;4(5). Kadosh D, Struhl K. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo Mol Cell Biol 1998 Sep;18(9):5121-5127. Kadosh D, Struhl K. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo Genes Dev 1998 Mar;12(6):797-805. Kadosh D, Struhl K. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters Cell 1997 May;89(3):365-371. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, Spierer P. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast Nature 1996 Dec;384(6609):589-591.

  Review Article

  Kadosh D. Regulatory Mechanisms Controlling Morphology and Pathogenesis in Candida albicans Curr Opin Microbiol 2019 Jan;52:27-34. Kadosh D. Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms Cell Mol Life Sci 2016 Jun;73(22):4265-4278. Albataineh M
  Kadosh D. Regulatory roles of phosphorylation in model and pathogenic fungi Med Mycol 2016 May;54(4):333-352. Kadosh D. Shaping up for battle: morphological control mechanisms in human fungal pathogens PLoS Pathog 2013 Dec;9(12):100379-100379. Kadosh D, Lopez-Ribot, JL. Candida albicans: adapting to succeed Cell Host Microbe 2013 Nov;14(5):483-485. Thompson DS, Carlisle PL, Kadosh D. Coevolution of morphology and virulence in Candida species Eukaryot Cell 2011 Sep;10(9):1173-1182. Struhl K, Kadosh D, Keaveney M, Kuras L, Moqtaderi Z. Activation and repression mechanisms in yeast Cold Spring Harbor Symp Quant Biol 1998 Jan;63:413-421.