Project Number: R21 HD088948
(E Kraig, Contact PI; C Li and Q Dong, Pis)
Title: Maternal obesity and immune developmental programming, role of the microbiome
The goal of this R21 is to assess the effects of a high fat diet during pregnancy on the developing immune system and microbiome. This is modeled in a baboon cohort.
Dates of Proposed Project: 8/1/2016-7/31/2020
Pepper Center Rapid Turnaround Grant
(E Kraig, Contact PI for pilot; D Kellogg, Co-PI)
Source: NIH/NIA (Pepper Center pilot grant)
Title: Rapamycin in the elderly: Effects on the DNA methylation age profile
The goal is to determine whether mTOR inhibition can reverse age-associated changes in DNA methylation.
Dates of Proposed Project: 4/1/2019-7/31/2020
CTSA/IIMS COVID-19 pilot grant
(D Kellogg, Contact PI for pilot; E Kraig Co-PI)
Source: NIH (CTSA pilot grant)
Title: Effects of mTOR inhibition with Rapamycin in patients with COVID-19 to ameliorate progression to Acute Respiratory Distress Syndrome (RAPA-CARDS)
The goal is to determine whether rapamycin can slow the progression of lung damage in late stage COVID infection.
Dates of Proposed Project: 7/1/2020-6/30/2021
PART THE CLOUD (PTC) Clinical Trials Program
(S Seshadri and M Gonzales, PIs; E Kraig, Co-I)
Source: Alzheimer’s Association
Title: Phase 2 Trial of Rapamycin for Alzheimer's Disease
The goal of this project is to conduct a placebo-controlled trial of rapamycin in subjects with cognitive impairment.
Dates of Proposed Project: 7/1/2020-12/31/2025