Kristine S Vogel, B.A., Ph.D.

Research: Animal models for NF1-associated tumors; DNA damage in NF1 tumorigenesis; tumor suppressor gene function in neural crest development  

Teaching: Neuroscience (neuroanatomy, neurophysiology, and neuroembryology, Mind, Brain & Behavior module Co-Director; neuroanatomy, Craniofacial Complex course); gross anatomy and embryology (head & neck anatomy, Language of Medicine and Craniofacial Complex courses; musculoskeletal anatomy, Form & Function module); Disability Studies

• Professional Background

  Education

  • 1988 - PhD - Cellular and Developmental Biology - University of Oregon
  • 1983 - BA - Anthropology (Magna Cum Laude) - Rice University
  • 1983 - BA - Biology (Magna Cum Laude) - Rice University
  • Postdoctoral Fellowship - Developmental Neurobiology - St. George's Hospital Medical School
  • Postdoctoral Training - Mammalian Genetics and Development - University of Texas Southwestern Medical School
  • Postdoctoral Training - Developmental Neurobiology - University of Oregon

  Appointments

  • 10/2000 - Assistant Professor - UTHSCSA, Cellular & Structural Biology, San Antonio

• Instruction & Training

  • 1/2018 - Present, Advanced Anatomy, The University of Texas Health Science Center
  • 9/2017 - Present, Craniofacial Complex, The University of Texas Health Science Center
  • 7/2017 - Present, Mind, Brain Behavior, The University of Texas Health Science Center
  • 1/2016 - Present, Musculoskeletal Dermatology, The University of Texas Health Science Center
  • 7/2014 - Present, Language of Medicine, The University of Texas Health Science Center
  • 10/2011 - Present, Ph.D. Dissertations Directed, UTHSCSA
  • 9/2009 - Present, Ph.D. Dissertations Directed, UTHSCSA
  • 9/2009 - Present, Ph.D. Dissertations Directed, UTHSCSA
  • 8/2009 - Present, Ph.D. Dissertations Directed, UTSA
  • 8/2001 - Present, Advanced Anatomy, The University of Texas Health Science Center
  • 10/2000 - Present, I. Educational Philosophy, UTHSCSA

• Research & Grants

  Neurofibromatosis type 1 (NF1) is a common inherited cancer syndrome, characterized by Schwann cell tumors (neurofibromas), as well as an increased risk of malignancies, bone disorders, and CNS manifestations.  Family members with the same mutation in the NF1 gene may have very different disease severity and outcomes, and the mechanisms underlying this variable expressivity are unknown.  I am using human neurofibroma-derived Schwann cells, as well as mouse models of NF1, to examine the roles of DNA damage and repair genes in modifying NF1 disease severity.

• Publications

  Journal Article

  Deng Y, Qin Y, Srikantan S, Luo A, Cheng ZM, Flores SK, Vogel KS, Wang E, Dahia PLM. The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex Human Molecular Genetics 2018 Jan;27:1794-1808. Dao V, Yeh P-H, Vogel KS, Moore CM. Applied neuroanatomy elective to reinforce and promote engagement with neurosensory pathways using interactive and artistic activities Anatomical Sciences Education 2014 Jun;8:166-174. Vogel KS, Perez, M., Momand, J.R., Acevedo-Torres, K., Hildreth, K., Garcia, R.A., Torres-Ramos, C.A., Ayala-Torres, S., Prihoda TJ, McMahan CA, Walter CA. Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice Molecular Reproduction and Development 2011 Aug;.