Carlos’ research focuses on the induction of sustained and anamnestic antibody responses and epigenetic regulation of the generation of memory B cells independently of T cells. He is working in the lab of Dr. Casali whose main focus of research is on mechanisms of immunoglobulin locus activation and targeting.
Yan H, Fernandez M, Wang J, Wu S, Wang R, Lou Z, Moroney JB, Rivera CE, Taylor JR, Gan H, Zan H, Kolvaskyy D, Liu D, Casali P, Xu Z. B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching. J Immunol. 2020 Jan 13. pii: ji1901170. doi: 10.4049/jimmunol.1901170. [Epub ahead of print] PMID: 31932498
Lam T, Kulp DV, Wang R, Lou Z, Taylor J, Rivera CE, Yan H, Zhang Q, Wang Z, Zan H, Ivanov DN, Zhong G, Casali P, Xu Z. Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus. J Immunol. 2016 Nov 15;197(10):3792-3805. Epub 2016 Oct 14. PMID: 27742832