My research focuses on the development of humanized mouse with a fully functional human immune system. We have designed a novel method of implanting a human immune system into mice that have had their natural immune systems deleted. We have recently characterized their antibody response and are investigating the epigenetic regulation of autoantibody production within a model of lupus, generated in our humanized mice platform. This platform allows for more accurate disease modeling and production of human antibodies, leading to a patent and multiple manuscripts to be submitted for publication within the next few months.
Casali, Paolo, Tian Shen, Yijiang Xu, Zhifang Qiu, Daniel P. Chupp, John Im, Zhenming Xu, and Hong Zan. “Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of MiR-26a.” Frontiers in Immunology 11 (2020). https://doi.org/10.3389/fimmu.2020.00491.
Gan, Huoqun, Tian Shen, Daniel P. Chupp, Julia R. Taylor, Helia N. Sanchez, Xin Li, Zhenming Xu, Hong Zan, and Paolo Casali. “B Cell Sirt1 Deacetylates Histone and Non-Histone Proteins for Epigenetic Modulation of AID Expression and the Antibody Response.” Science Advances 6, no. 14 (2020). https://doi.org/10.1126/sciadv.aay2793.
B.S., Biochemistry, Indiana University South Bend, 2015
2017 Awarded first place poster presentation at the annual Vaccine Development Center of San Antonio Conference.
2018 Passed qualifying examination
2018 Selected to be supported by the Graduate Research in Immunology Program (GRIP) NIH T32 training grant
2019 Awarded first place poster presentation at the annual Vaccine Development Center of San Antonio Conference.
2019 Awarded UT Health San Antonio MIMG department travel award.
2019 Awarded first place poster presentation at the UT Health San Antonio MIMG department retreat.
2019 Awarded second place poster presentation at Mikiten graduate research symposium
2019 Selected to present at the American Association of Immunology annual meeting in San Diego, CA
2019 Selected to be supported by the Graduate Research in Immunology Program (GRIP) NIH T32 training grant
2019 Selected to by faculty as student representative on the new student recruitment committee
2020 Selected to present research at Texas Academy of Medicine, Engineering & Science (TAMEST) conference