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Justin Moroney

Programs

IBMS Discipline

Mentor

Justin Moroney

Ph.D. Student

Biography

My research focuses on the transcriptional identity of human memory B cells and its intersect with epigenetic regulatory mechanisms mediated by chromatin remodeling and non-coding RNAs. In turn, these molecular processes shape the functionality and phenotype of switched memory B cells and contribute to human health and disease. By understanding the critical factors involved in the functionality and persistence of human memory B cells, we believe we can leverage these findings to improve vaccine efficacy and durability and thus significantly impact human health.

Publications

Moroney, Justin & Vasudev, Anusha & Pertsemlidis, Alexander & Zan, Hong & Casali, Paolo. (2020). Integrative analysis of coding, non-coding transcriptome and chromatin accessibility reveals a distinct gene expression and epigenetic landscape in human memory B cells. Nat. Commun.In Review. 

Yan, Hui & Fernandez, Maria & Wang, Jingwei & Wu, Shuai & Wang, Rui & Lou, Zheng & Moroney, Justin & Rivera, Carlos & Taylor, Julia & Gan, Huoqun & Zan, Hong & Kolvaskyy, Dmytro & Liu, Dongfang & Casali, Paolo & Xu, Zhenming. (2020). B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching. The Journal of Immunology. ji1901170. 10.4049/jimmunol.1901170. 

Sanchez, Helia & Moroney, Justin & Gan, Huoqun & Shen, Tian & Im, John & Li, Tianbao & Taylor, Julia & Zan, Hong & Casali, Paolo. (2020). B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids. Nature Communications. 11. 10.1038/s41467-019-13603-6. 

Hsu, Shu-Hao & Delgado, Evan & Otero, Anthony & Teng, Kun-yu & Kutay, Huban & Meehan, Kolin & Moroney, Justin & Monga, Jappmann & Hand, Nicholas & Friedman, Joshua & Ghoshal, Kalpana & Duncan, Andrew. (2016). MicroRNA-122 Regulates Polyploidization in the Murine Liver. Hepatology (Baltimore, Md.). 64. 10.1002/hep.28573. 

Education

B.S., University of Pittsburgh 

Awards

2017               Selected for oral presentation at the 6th Annual Vaccine Development Center of San AntonioConference

2018               Awarded first place oral presentation at the 2018 Microbiology, Immunology & Molecular Genetics Annual Retreat Conference

2018                Awarded a T32 slot position in the Graduate Research in Immunology Program (GRIP) (NIH T32 AI138944)

2018               Selected for oral presentation at the 7th Annual Vaccine Development Center of San AntonioConference

2019               Selected for oral presentation at AAI’s Immunology 2019, San Diego, CA

2019                Awarded for 2019 AAI Trainee Abstract Travel Award

2019                Awarded for Spring 2019 MIMG Department Travel Award

2019                Re-awarded T32 trainee slot in the Graduate Research in Immunology Program (GRIP) (NIH T32 AI138944)

2019                Awarded position in UT Health’s Interprofessional Leadership Programs

2020                Conference assistant at the B cell Keystone conference 2020, Banff, Canada

2020                Awarded B cell Keystone symposia Travel Award

2020               Selected for oral presentation at AAI’s Immunology 2020, Honolulu, HI

2020                Awarded 2020 AAI Trainee Abstract Travel Award

2020                Awarded for Spring 2020 MIMG Department Travel Award

2020                Awarded for Spring 2020 GSBS Travel Award

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