Ryan Reyes is a fourth-year graduate student in the lab of Tyler Curiel, MD MPH. The Curiel lab studies cancer immunotherapy and has expertise in using mouse models for translational research. Ryan’s project focuses on the use of novel approaches to target cancer fighting immune cells in the tumor microenvironment of bladder cancer. Upon completion of his PhD, he will return to medical school and then pursue a residency/fellowship in Internal Medicine/Hematology & Oncology.
Ryan M Reyes, Yilun Deng, Deyi Zhang, Niannian Ji, Neelam Mukherjee, Karen Wheeler, Harshita B Gupta, Alvaro S Padron, Aravind Kancharla, Chenghao Zhang, Myrna G Garcia, Anand VR Kornepati, Onur Boyman, José R. Conejo-Garcia, Robert S Svatek, Tyler J Curiel. (2020) CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation. The Journal for the Immunotherapy of Cancer, in press.
Deyi Zhang§, Ryan M Reyes§, Erica Osta, Suresh Kari, Harshita B Gupta, Alvaro S Padron, Anand VR Kornepati, Aravind Kancharla, Xiujie Sun, Yilun Deng, Bogang Wu, Ratna Vadlamudi, Rong Li, Robert S Svatek, Tyler J Curiel. (2020). Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy. Cancer Medicine, in press.
Justin M Drerup, Yilun Deng, Sri Lakshmi Pandeswara, Álvaro S. Padrón, Ryan M Reyes, Xinyue Zhang, Jenny Mendez, Aijie Liu, Curtis A. Clark, Wanjiao Chen, José R Conejo-Garcia, Vincent Hurez, Harshita Gupta and Tyler J Curiel. CD122-selective IL-2 complexes reduce immunosuppression, promote Treg fragility, and sensitize tumor response to PD-L1 blockade. Cancer Res. 2020 Sep 18:canres.0002.2020. doi: 10.1158/0008-5472.CAN-20-0002. PMCID: PMC7669742
Rios, Emily & Parma, Mitchell & Fernandez, Roman & Clinton, Timothy & Reyes, Ryan & Kaushik, Dharam & Pruthi, Deepak & Mansour, Ahmed & Mukherjee, Neelam & Gelfond, Jon & Wheeler, Karen & Svatek, Robert. (2019). Urinary Diversion Disparity Following Radical Cystectomy for Bladder Cancer in the Hispanic Population. Urology. 10.1016/j.urology.2019.12.017.
CTSA Translational Science (TL-1) Fellowship Award, 2018
Biology of Aging T32 Predoctoral Trainee
B.S., University of Arkansas at Monticello