Ryan Reyes is a fourth-year graduate student in the lab of Tyler Curiel, MD MPH. The Curiel lab studies cancer immunotherapy and has expertise in using mouse models for translational research. Ryan’s project focuses on the use of novel approaches to target cancer fighting immune cells in the tumor microenvironment of bladder cancer. Upon completion of his PhD, he will return to medical school and then pursue a residency/fellowship in Internal Medicine/Hematology & Oncology.
Reyes RM, Deng Y, Zhang D, Ji N, Mukherjee N, Wheeler K, Gupta HB, Padron AS, Kancharla A, Zhang C, Garcia M, Kornepati AVR, Boyman O, Conejo-Garcia JR, Svatek RS, Curiel TJ. CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation. J Immunother Cancer. 2021 Apr;9(4):e002051. doi: 10.1136/jitc-2020-002051. PMID: 33849925; PMCID: PMC8051418.
Zhang D§, Reyes RM§, Osta E, Kari S, Gupta HB, Padron AS, Kornepati AVR, Kancharla A, Sun X, Deng Y, Wu B, Vadlamudi R, Li R, Svatek RS, Curiel TJ. Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy. Cancer Med. 2021 Mar;10(6):2137-2152. doi: 10.1002/cam4.3739. Epub 2021 Feb 24. PMID: 33626233; PMCID: PMC7957205. §indicates joint first authorship
Reyes RM, Rios E, Barney S, Hugen CM, Michalek JE, Lotan Y, Messing EM, Robert S. Svatek RS. A randomized feasibility trial comparing surveillance regimens for patients with low and low-intermediate risk non-muscle invasive bladder cancer. Bladder Cancer. In press
Ji N, Mukherjee N, Reyes RM, Gelfond J, Javors M, Meeks JJ, McConkey DJ, Shu ZJ, Ramamurthy C, Dennett R, Curiel TJ, Svatek RS. Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study. J Immunother Cancer. 2021 Mar;9(3):e001941. doi: 10.1136/jitc-2020-001941. PMID: 33653802; PMCID: PMC7929866.
Ji N, Mukherjee N, Shu ZJ, Reyes RM, Meeks JJ, McConkey DJ, Gelfond J, Curiel TJ, Svatek RS. γδ T cells support induction of antigen-specific αβ T cells during BCG bladder cancer treatment. Cancer Immuno Res. In Press
Rios EM, Parma MA, Fernandez RA, Clinton TN, Reyes RM, Kaushik D, Pruthi D, Mansour AM, Mukherjee N, Gelfond J, Wheeler KM, Svatek RS. Urinary Diversion Disparity Following Radical Cystectomy for Bladder Cancer in the Hispanic Population. Urology. 2020 Mar;137:66-71. doi: 10.1016/j.urology.2019.12.017. Epub 2019 Dec 27. PMID: 31883879; PMCID: PMC7063861.
Drerup JM, Deng Y, Pandeswara SL, Padrón ÁS, Reyes RM, Zhang X, Mendez J, Liu A, Clark CA, Chen W, Conejo-Garcia JR, Hurez V, Gupta H, Curiel TJ. CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade. Cancer Res. 2020 Nov 15;80(22):5063-5075. doi: 10.1158/0008-5472.CAN-20-0002. Epub 2020 Sep 18. PMID: 32948605; PMCID: PMC7669742.
2021: Top Student Presentation, The Robert A. Clark Frontiers of Translational Science Research Day, Mays Cancer Center Retreat, & UT Health San Antonio MD/PhD Retreat
2020: American Association of Immunologists Trainee Abstract Award for Oral Presentation and UT Health San Antonio Microbiology, Immunology and Molecular Genetics Department Travel Award. Biology of Aging T32 Predoctoral Trainee.
2019: Translational Science Training TL1 Program Scholar, UT Health San Antonio
2018: Travel Award for Poster Presentation, 33rd Annual National MD/PhD Student Conference
B.S., University of Arkansas at Monticello