
Programs
IBMS Discipline
Mentor
Sergio Cepeda
Ph.D. Student
Biography
Sergio’s research interest involves the development and function of intrathymic B cells. The thymus has been traditionally thought of as an organ for T cell development but recent evidence suggests a permanent population of B cells exists as well. The purpose of these B cells is largely unknown, however, making them a new and exiting question in an old field. We have recently identified age-associated accumulation of these cells in the thymus and are working towards understanding the function and kinetics of these cells in both young and aged animals.
Publications
Cepeda S, Cantu C, Orozco S, Xiao Y, Brown Z, Semwal MK, Venables T, Anderson MS, Griffith AV. Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens. Cell Rep. 2018 Jan 30;22(5):1276-1287. doi: 10.1016/j.celrep.2018.01.015. PMID: 29386114
Cepeda S, Griffith AV. Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus. Exp Gerontol. 2018 May;105:113-117. doi: 10.1016/j.exger.2017.12.022. Epub 2017 Dec 24. Review. PMID: 2927875
Awards
Howard Hughes Medical Institute Gilliam Fellowship, 2018
AAI Trainee Poster Award – Poster Presentation, 2018