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Armen N. Akopian, B.Sc., M.Sc., Ph.D.
Dental School
Endodontics
210-567-6668
akopian@uthscsa.edu
Education
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| Year | Degree | Discipline | Institution |
| 2001 | Postdoctoral Fellowship | Molecular Neuroscience, Research Fellow | University College of London London , United Kingdom |
| 1997 | Postdoctoral Fellowship | Molecular Neuroscience, Postdoctoral Fellowship | University College of London London , United Kingdom |
| 1994 | PhD | Biochemistry, Molecular Biology & Science | Engelhardt Institute of Molecular Biology, Branch of Biological Sciences Moscow , USSR |
| 1994 | Postdoctoral Fellowship | Medical Research, Postdoc Fellowship | Sandoz Institute of Medical Research London , United Kingdom |
| 1987 | MS | Biology | Armenia State University USSR |
| 1985 | BS | Physics | Armenia State University USSR |
Appointments
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| 1/2013 - Present | Associate Professor with Tenure | University of Texas Health Science Center at San Antonio |
| 6/2011 - Present | Assistant Professor and Credentialed Mentoring Faculty Member | Graduate School of Biomedical Sciences, UTHSCSA, Pharmacology, San Antonio, TX |
Expertise
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1-Pain modulation in pathological conditions - (inflammatory and neuropathic pain) |
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2-Molecular and cellular biology - -Isolation and synthesis of nucleic acids: DNA and RNA. -Construction of vectors and libraries. -Screening of genomic and cDNA libraries. -In situ hybridization: non-radioactive and radioactive. -Transfection and propogations of cell lines (primary and secondary) |
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3-Biochemistry - -Protein isolation and protein fraction enrichment. -Western and immunoprecipitation. -Immuno-stainings. |
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4-Electrophysiology - -All aspects of patch clamping. |
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5-Fluorescent imaging - -Ca-imaging |
Publications
Abstract |
| Patil MJ, Brooks EG, Henry MA, Akopian AN. Der p 3 Allergen Activated Ano-1 Channel On Afferent Airway Nerves Regulates Th2 Cell Responses; 2014 Jan. (J. Allergy Clin. Immunol). |
| Akopian AN, Henry MA, Patil M, Brooks EG. House Dust Mite Group 2 Allergens Modulates LPS-induced Responses in Airway Sensory Neurons; 2013 Jan. (J. Allergy Clin Immunol). |
Journal Article |
| Akopian AN, Hovhannisyn, AH, Patil, Mayur M. Characteristics of sensory neuronal groups in CGRP-1 cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines Public Library of Science 2018 Jan;13(6). |
| Mecklenburg J, Patil M, Koek W, Akopian AN. Effects of local and spinal administrations of mu-opioids on postoperative pain in aged vs adult mice Pain Reports 2017 Jan;. |
| Akopian AN, Fanick ER, Brook EG. TRP channels and traffic-related environmental pollution-induced pulmonary disease Semin Immunopathol 2016 May;38(3):331-338. |
| Brackley AD, Gomez R, Akopian AN, Henry MA, Jeske NA. GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity Cell Report 2016 Jan;16(10):2686-2698. |
| Patil M,Henry M, Goffin V, Akopian AN. (300) Prolactin regulates sensory neurons in a female-specific manner at their peripheral and central terminals and not at their cell bodies The Journal of Pain 2016 Jan;17(4). |
| Akopian AN et. al. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain Neuron 2016 Jan;85(4):833-846. |
| Akopian AN. Role of TRP ion channels in physiology and pathology Semin Immunopathol 2016 Jan;38(3):275-276. |
| Grattan DR, Akopian AN. Oscillating from Neurosecretion to Multitasking Dopamine Neurons Cell Report 2016 Jan;15(4):681-682. |
| Akopian AN et. al. The TRPA1 ion channel is expressed in CD4 T cells and restrains T-cell-mediated colitis through inhibition of TRPV1 Gut 2016 Jan;. |
| Green D, Patil M, Akopian AN. Influence of Hypophysectomy, Ovariectomy and Gonadectomy on Postoperative Hypersensitivity in Rats Global Anesthesia and Perioperative Medicine 2016 Jan;2(2):171-175. |
| Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian A, Hargreaves K. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury Molecular Pain 2016 Jan;. |
| Weng H-J, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiari V, Zheng Q, Tang Z, Mo GCH, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain Neuron 2015 Jan;85:1-14. |
| Patil, M.J. Henry, M.A Akopian A.N. Prolactin Receptor in Regulation of Neuronal Excitability and Channels Channels 2014 Jan;8(3):193-202. |
| Belguin S, Diogenes A, Patil M, Ginsburg E, Henry MA, Akopian AN. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons Journal of Biological Chemistry 2013 Oct;288(48):34943-34955. |
| Akopian AN, Por E, Gomez R, Jeske NA. Phosphorylation regulates TRPV1 association with b-arrestin-2 Biochemical Journal 2013 Jan;451(1):101-109. |
| Patil, MJ Green, DP Henry, MA Akopian AN. Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice Neuroscience 2013 Jan;253:132-141. |
| Patil, MJ Henry, MA Akopian AN. Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in sex-dependent manner: contribution of prolactin receptor to inflammatory pain Am. J. Physiol: Endocrinology and Metabolism 2013 Jan;305(9):E1154-E1164. |
| Ruparel S, Henry MA, Akopian AN, Patil. Mayur J, Zeldin. D.S., Roman. L.J., Hargreaves KM. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. AT PRESS PAIN 2012 Oct;153(10):2031-2039. |
Not Specified |
| Brackley AD, Gomez R, Guerrero KA, Akopian AN, Glucksman MJ, Du J, Carlton SM, Jeske NA. A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation Sci Rep 2017 Jan;. |
Teaching
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| Date | Description | Institution | # Students |
| 7/2009 - Present | Post-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
Grants
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Federal |
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| Funding Agency | NIH/NNDS |
| Title | Meningeal prolactin signaling and female-selective migraine mechanisms |
| Status | Active |
| Period | 8/2018 - 8/2023 |
| Role | Co-Investigator |
| Grant Detail | The major goals of this project are to investigate the role of meningeal prolactin system in female-selective mechanisms of migraine triggered by vasodilatory hormone CGRP and stress. |
| Funding Agency | NIH |
| Title | Sex-Specific regulation of local translation and chronic pain mechanisms in females |
| Status | Active |
| Period | 7/2018 - 6/2023 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH |
| Title | Prolactin regulation of postoperative pain in males and females |
| Status | Active |
| Period | 9/2015 - 8/2019 |
| Role | Principal Investigator |
| Grant Detail | The major goals of this project are to identify and characterize female-specific mechanisms in regulation of postoperative pain |
| Funding Agency | NIH-NIGMS |
| Title | Evaluation of Endogenous TRP Agonists in Human Burns |
| Status | Active |
| Period | 12/2013 - 1/2017 |
| Role | Co-Investigator |
| Grant Detail | The long term goal of this project is to examine modulation of burn pain by oxidized linoleic acid metabolites |
State |
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| Funding Agency | University of Texas, UT BRAIN Seed Grant |
| Title | PROLACTIN AND SEX-DEPENDENCE OF MIGRAINE |
| Status | Active |
| Period | 10/2015 - 10/2016 |
| Role | Principal Investigator |
| Grant Detail | Accumulation of preliminary results on sex-dependent and stress-dependent regulation of migraine by prolactin |
| Funding Agency | UTHSCSA |
| Title | Neuropathic Pain in Aging |
| Status | Active |
| Period | 8/2015 - 8/2016 |
| Role | Principal Investigator |
| Grant Detail | Main goal of the project is to test contribution of age to pain |