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  • Hargreaves, Kenneth M

Kenneth M. Hargreaves, D.D.S., Ph.D.

Dental School
Endodontics
210-567-3381
hargreaves@uthscsa.edu

Kenneth Hargreaves D.D.S., Ph.D.

Dr. Hargreaves received his B.A. in neurobiology from the University of California at Berkeley in 1977, his D.D.S. from Georgetown University in Washington, D.C., in 1983, and his Ph.D. in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in 1986.

From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently professor and chair of the Department of Endodontics, and professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at UT Health San Antonio. He also maintains a private practice limited to endodontics.

Research Interests:  Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics, regenerative endodontics, clinical and translational research

Primary research interests are in the areas of pain and inflammation. His research team has published more than two hundred papers that have generated more than 15,000 life-time citations. He has also edited two textbooks, Seltzer and Benders Dental Pulp, and Cohen’s Pathways of the Pulp. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic and other pain patients, as well as the clinical outcomes of non-surgical endodontic procedures.

Expertise:  Endodontic diagnosis, prognosis, treatment, Mechanisms of Apical Periodontitis

Research Interests

Head & Neck Cancer, Pain

Experimental and Developmental Therapeutics Program

Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics

Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, Seltzer and Benders Dental Pulp, co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures.

  • Education
  • Appointments
  • Expertise
  • Publications
  • Teaching
  • Grants

Education

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Year Degree Discipline Institution
1993 Postdoctoral Training Endodontics University of Minnesota, School of Dentistry
Minneapolis , MN
1990 Postdoctoral Fellowship Sr Staff Fellow-Neurobiol & Anesthes Branch National Institute of Dental Research, NIH
Bethesda , MD
1988 Postdoctoral Fellowship Postdoc Fellow-Neurobiol & Anesthes Branch National Institute of Dental Research, NIH
Bethesda , MD
1986 PhD Physiology Uniformed Services University of the Health Sciences
Bethesda , MD
1985 Postdoctoral Fellowship NRSA Postdoc Fellow-Neurobiol & Anesthes Branch National Institute of Dental Research, NIH
Bethesda , MD
1983 DDS Dentistry Georgetown University
Washington , DC
1981 Internship Research Assistant, Pharmacology Georgetown University
Washington , DC
1980 Internship Predoc Research Fellow, School of Dentistry Georgetown University
Washington , DC
1977 BA Neurobiology University of California at Berkeley
Berkeley , CA

Appointments

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12/2015 - Present COSTAR Director University of Texas Health Science Center at San Antonio, San Antonio, TX
3/2007 - Present Professor University of Texas Health Science Center at San Antonio, Physiology, San Antonio, TX
3/2007 - Present Professor University of Texas Health Science Center at San Antonio, Surgery, San Antonio, TX
9/2005 - Present President`s Council Chair in Dental Research Endowment University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX
1/2003 - Present Editor-in-Chief Journal of Endodontics, official journal of the American Association of Endodontists
7/1997 - Present Professor University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio, TX
7/1997 - Present Professor and Chair and Department Chair University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX
7/1997 - Present Endodontist University of Texas Health Science Center at San Antonio, Faculty Practice, Faculty Practice, San Antonio, TX

Expertise

Analgesics
Clinical Therapeutics in Endodontics
Hyperalgesia
Inflammation
Pain
Pain & Inflammation, Analgesics, Hyperalgesia..... -
Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics: Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, "Seltzer and Bender`s Dental Pulp," co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures.

Publications

Book/Monograph

Hargreaves KM, Berman L. Cohen?s Pathways of the Pulp, 11th edition St. Louis: Elsevier; 2016.

Journal Article

Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian AN, Hargreaves KM. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury Molecular Pain 2016 Jan;12.
Eskander M, Ruparel S, Green D, Por E, Chen P, Jeske NA, Gao X, Flores E, Hargreaves KM. Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms Journal of Neuroscience 2015 Jun;35(22):8593-8603.
Dissanayaka WL, Zhu L, Hargreaves KM, Jin L, Zhang C. In Vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells Journal of Endodontics 2015 Jan;41:663-670.
Fehrenbacher J, Bingener J, Aho J, Wasky P, Locke E, Schwesinger W, Van Sickle K, Hargreaves KM. Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study Chirungia 2015 Jan;.
Gonzales CB, Kirma NB, De La Chapa J, Chen R, Henry MA, Luo S, Hargreaves KM. Vanilloids induce oral cancer apoptosis independent of TRPV1 interactions Oral Oncology 2014 May;50(5):437-447.

Not Specified

Dissanayaka WL, Hargreaves KM, Jin L, Samaranayake L, Zhang C. The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo Tissue Eng Part A 2015 Jan;21:550-563.

Teaching

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Date Description Institution # Students
1/2015 - Present Ph.D. Dissertations Directed University of Texas Health Science Center at San Antonio
1/2014 - Present Masters' Thesis Directed University of Texas Health Science Center at San Antonio
1/2014 - Present Ph.D. Dissertations Directed University of Texas Health Science Center at San Antonio
9/2011 - Present Ph.D. Dissertations Directed PhD Program in Pharmacology, UTHSCSA
4/2011 - Present Pharmacology The University of Texas Health Science Center
Opiates/NSAIDS
1/2010 - Present Membership on Supervising Committee Physiology, UTHSCSA
8/2008 - Present Fundamentals of Neuroscience II The University of Texas Health Science Center
Peripheral Sensory Receptors, Receptor Potentials & Sensory Coding; Spinal and Ascending Somatic Sensory Pathways; Pain, Nociception and Antinociception I & II.
1/2008 - Present Graduate (Adv Education in Endodontics)
Course Director
7/1999 - Present Endodontics Clinic The University of Texas Health Science Center
1/1999 - Present ENDO5011 Clinical Endodontics I
1/1999 - Present Clinical Endodontics
1/1999 - Present Core Course Oral Biology (Dental Biomedical Core II)
1/1999 - Present Clinical Endodontics I The University of Texas Health Science Center
1/1999 - Present Clinical Endo II The University of Texas Health Science Center
1/1999 - Present Clinical Endodontics II The University of Texas Health Science Center
1/1999 - Present Clinical Endo II The University of Texas Health Science Center
7/1998 - Present Endodontics Seminar The University of Texas Health Science Center
7/1998 - Present Neuropsychopharmacology
1/1998 - Present Endodontics Clinic The University of Texas Health Science Center
Junior
1/1998 - Present Clinical Endodontics
1/1998 - Present Graduate Endodontics
1/1998 - Present Sophomore Endodontics
1/1998 - Present Periodontal Topics
1/1998 - Present Clinical Seminar I The University of Texas Health Science Center
1/1998 - Present Endodontics Lecture The University of Texas Health Science Center
Sophomore
9/1997 - Present Endodontics Lecture The University of Texas Health Science Center
1/1997 - Present Junior Endodontics

Grants

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Federal

Funding Agency NIDR
Title Oral Surgery & Initiation of Neurogenic Inflammation
Status Complete
Period - Present
Role Co-Principal Investigator
Grant Detail
Funding Agency Department of Defense
Title Developing Novel Analgesics for Treating Burn Pain
Status Active
Period 1/2015 - 1/2018
Role Principal Investigator
Grant Detail Test novel analgesic regimes targeting TRPV1 in a murine burn model

Private

Funding Agency USAA Foundation
Title New Method to Treat Burn Pain in Our Wounded Warriors
Status Active
Period 6/2010 - 1/2029
Role Principal Investigator
Grant Detail
Funding Agency Barker Foundation
Title Pain Management
Status Active
Period 1/2013 - 1/2018
Role Principal Investigator
Grant Detail

Funding Agency American Association for Endodontists Foundation
Title Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots
Status Active
Period 1/2013 - 1/2019
Role Principal Investigator
Grant Detail PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves.
This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics.

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