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Dr. Hargreaves received his B.A. in neurobiology from the University of California at Berkeley in 1977, his D.D.S. from Georgetown University in Washington, D.C., in 1983, and his Ph.D. in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in 1986.
From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently professor and chair of the Department of Endodontics, and professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at UT Health San Antonio. He also maintains a private practice limited to endodontics.
Research Interests
Head & Neck Cancer, Pain
Experimental and Developmental Therapeutics Program
Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics
Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, Seltzer and Benders Dental Pulp, co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures.
Education
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| Year | Degree | Discipline | Institution |
| 1993 | Postdoctoral Training | Endodontics | University of Minnesota, School of Dentistry Minneapolis , MN |
| 1990 | Postdoctoral Fellowship | Sr Staff Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1988 | Postdoctoral Fellowship | Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1986 | PhD | Physiology | Uniformed Services University of the Health Sciences Bethesda , MD |
| 1985 | Postdoctoral Fellowship | NRSA Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1983 | DDS | Dentistry | Georgetown University Washington , DC |
| 1981 | Internship | Research Assistant, Pharmacology | Georgetown University Washington , DC |
| 1980 | Internship | Predoc Research Fellow, School of Dentistry | Georgetown University Washington , DC |
| 1977 | BA | Neurobiology | University of California at Berkeley Berkeley , CA |
Appointments
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| 12/2015 - Present | COSTAR Director | University of Texas Health Science Center at San Antonio, San Antonio, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Surgery, San Antonio, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Physiology, San Antonio, TX |
| 9/2005 - Present | President`s Council Chair in Dental Research Endowment | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 1/2003 - Present | Editor-in-Chief | Journal of Endodontics, official journal of the American Association of Endodontists |
| 7/1997 - Present | Professor | University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio, TX |
| 7/1997 - Present | Professor and Chair and Department Chair | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 7/1997 - Present | Endodontist | University of Texas Health Science Center at San Antonio, Faculty Practice, Faculty Practice, San Antonio, TX |
Expertise
| Analgesics |
| Clinical Therapeutics in Endodontics |
| Hyperalgesia |
| Inflammation |
| Pain |
|
Pain & Inflammation, Analgesics, Hyperalgesia..... - Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics: Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, "Seltzer and Bender`s Dental Pulp," co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures. |
Publications
Book/Monograph |
| Hargreaves KM, Berman L. Cohen?s Pathways of the Pulp, 11th edition St. Louis: Elsevier; 2016. |
Journal Article |
| Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian AN, Hargreaves KM. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury 2016 Jul;12. |
| Eskander M, Ruparel S, Green D, Por E, Chen P, Jeske NA, Gao X, Flores E, Hargreaves KM. Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms Journal of Neuroscience 2015 Jun;35:8593-8603. |
| Dissanayaka WL, Zhu L, Hargreaves KM, Jin L, Zhang C. In Vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells Journal of Endodontics 2015 Jan;41:663-670. |
| Fehrenbacher J, Bingener J, Aho J, Wasky P, Locke E, Schwesinger W, Van Sickle K, Hargreaves KM. Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study Chirungia 2015 Jan;. |
| Gonzales CB, Kirma NB, De La Chapa J, Chen R, Henry MA, Luo S, Hargreaves KM. Vanilloids induce oral cancer apoptosis independent of TRPV1 interactions Oral Oncology 2014 May;50(5):437-447. |
| Dissanayaka WL, Zhu L, Hargreaves KM, Zhang C. Scaffold-free prevascularized microtissue spheroids for pulp regeneration Journal of Dental Research 2014 Jan;93:1296-1303. |
| Diogenes A, Ruparel NB, Teixeira FB, Hargreaves KM. Translational science in disinfection for regenerative endodontics Journal of Endodontics 2014 Jan;40:S52-S57. |
| Flake NM, Gibbs JL, Diogenes A, Hargreaves KM, Khan AA. A standardized novel method to measure radiographic root changes after endodontic therapy in immature teeth Journal of Endodontics 2014 Jan;40(1):46-50. |
| Hargreaves KM, Diogenes A, Teixeira FB. Paradigm lost: a perspective on the design and interpretation of regenerative endodontic research Journal of Endodontics 2014 Jan;40(4 Sup):S65-S69. |
| Chrepa V, Kotsakis G, Pagonis T, Hargreaves KM. The effect of photodynamic therapy in root canal disinfection: a systemic review Journal of Endodontics 2014 Jan;40:891-898. |
| Rowan MP, Berg KA, Roberts J, Hargreaves KM, Clarke W. Activation of estrogen receptor alpha enhances bradykinin signaling in peripheral sensory neruons of female rats J Pharmacol Expt Therap 2014 Jan;349:526-532. |
| Brandfellner HM, Ruparel SB, Gelfond JA, Hargreaves KM. Major Blunt Trauma Evokes a Selective Up-Regulation of Oxidative Enzymes in Circulating Leukocytes Shock 2013 Jun;. |
| Loyd D, Henry MA, Hargreaves KM. Serotonergic Neuromodulation of Peripheral Nociceptors Stem Cell Develop Biol 2013 Jan;24:51-57. |
| Hargreaves KM, Diogenes AR, Teixeira FB. Treatment options: biological basis of regenerative endodontics (in press) Journal of Endodontics 2013 Jan;. |
| Green D, Ruparel S, Roman LJ, Henry MA, Hargreaves KM. Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury PAIN 2013 Jan;154:2512-2520. |
| Ruparel S, Hargreaves KM, Eskander M, Rowan S, De Almeida JF, Roman L, Henry MA. The oxidized linoleic acid metabolite ? Cytochrome P450 system is active in biopsies from patients with inflammatory dental pain Pain 2013 Jan;. |
| Diogenes A, Henry MA, Teixeira FB, Hargreaves KM. An Update on Clinical Regenerative Endodontics Endodontic Topics 2013 Jan;28:2-23. |
| Ruparel S, Green D, Chen P, Hargreaves KM. The cytochrome P450 inhibitor, ketoconazole, inhibits OLAM-mediated peripheral inflammatory pain Molecular Pain 2012 Sep;8(73). |
Not Specified |
| Dissanayaka WL, Hargreaves KM, Jin L, Samaranayake L, Zhang C. The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo Tissue Eng Part A 2015 Jan;21:550-563. |
Teaching
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| Date | Description | Institution | # Students |
| 1/2015 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 1/2014 - Present | Masters' Thesis Directed | University of Texas Health Science Center at San Antonio | |
| 1/2014 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 9/2011 - Present | Ph.D. Dissertations Directed | PhD Program in Pharmacology, UTHSCSA | |
| 4/2011 - Present | Pharmacology | The University of Texas Health Science Center | |
| Opiates/NSAIDS | |||
| 1/2010 - Present | Membership on Supervising Committee | Physiology, UTHSCSA | |
| 8/2008 - Present | Fundamentals of Neuroscience II | The University of Texas Health Science Center | |
| Peripheral Sensory Receptors, Receptor Potentials & Sensory Coding; Spinal and Ascending Somatic Sensory Pathways; Pain, Nociception and Antinociception I & II. | |||
| 1/2008 - Present | Graduate (Adv Education in Endodontics) | ||
| Course Director | |||
| 7/1999 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics I | The University of Texas Health Science Center | |
| 1/1999 - Present | Core Course Oral Biology (Dental Biomedical Core II) | ||
| 1/1999 - Present | Clinical Endodontics | ||
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clincial Endodontics I | The University of Texas Health Science Center | |
| 7/1998 - Present | Endodontics Seminar | The University of Texas Health Science Center | |
| 7/1998 - Present | Neuropsychopharmacology | ||
| 1/1998 - Present | Clinical Seminar I | The University of Texas Health Science Center | |
| 1/1998 - Present | Periodontal Topics | ||
| 1/1998 - Present | Sophomore Endodontics | ||
| 1/1998 - Present | Graduate Endodontics | ||
| 1/1998 - Present | Clinical Endodontics | ||
| 1/1998 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| Junior | |||
| 1/1998 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| Sophmore | |||
| 9/1997 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| 1/1997 - Present | Junior Endodontics | ||
Grants
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Federal |
|
| Funding Agency | NIDR |
| Title | Oral Surgery & Initiation of Neurogenic Inflammation |
| Status | Complete |
| Period | - Present |
| Role | Co-Principal Investigator |
| Grant Detail | |
| Funding Agency | Department of Defense |
| Title | Developing Novel Analgesics for Treating Burn Pain |
| Status | Active |
| Period | 1/2015 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | Test novel analgesic regimes targeting TRPV1 in a murine burn model |
| Funding Agency | NIGMS SBIR |
| Title | Development of Anti-OLAM aptamers as novel analgesics |
| Status | Active |
| Period | 1/2015 - 1/2017 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH-NINDS |
| Title | Role of Oxidized Linoleic Acid Metabolites in Pain |
| Status | Complete |
| Period | 9/2010 - 8/2015 |
| Role | Principal Investigator |
| Grant Detail | This R01 utilizes molecular, electrophysiologic anatomical, biochemical and behavior methods to evaluae the role of endogenous TRPV1 agonists (OLAMS) in inflammatory pain. |
| Funding Agency | NIH |
| Title | South Texas Advanced Research Training: Undergraduate Program (START-UP) |
| Status | Complete |
| Period | 9/2010 - 8/2015 |
| Role | Contributor |
| Grant Detail | The purpose of this program is to increase the number of underrepresented minorities (URMs) entering doctoral programs in the neurosciences and then the biomedical workforce as Ph.D.?s. URMs are defined by ethnicity, socio-economic status and disabilities. |
Private |
|
| Funding Agency | USAA Foundation |
| Title | New Method to Treat Burn Pain in Our Wounded Warriors |
| Status | Active |
| Period | 6/2010 - 1/2029 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Barker Foundation |
| Title | Pain Management |
| Status | Active |
| Period | 1/2013 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | American Association for Endodontists Foundation |
| Title | Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots |
| Status | Active |
| Period | 1/2013 - 1/2019 |
| Role | Principal Investigator |
| Grant Detail | PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves. This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics. |
| Funding Agency | DSRIP |
| Title | Development of a Dental Pain Emergency Program |
| Status | Active |
| Period | 1/2013 - 1/2016 |
| Role | Principal Investigator |
| Grant Detail | |