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  • Pavlin, Dubravko

Dubravko Pavlin, D.M.D., Ph.D.

Dental School
Developmental Dentistry
210-567-3508
pavlin@uthscsa.edu

UT Health Science Center orthodontist Dr. Dubravko Pavlin

Dr. Pavlin's academic activities include the functions of program director for Orthodontic Residency and the director of Orthodontic Clinic.  He is the course director of several graduate courses at UT Health San Antonio and a lecturer in other didactic and clinical courses in our predoctoral program.  He is also directing a laboratory involved in research projects in the area of bone biology, and he serves as a reviewer for several basic science and clinical journals.

Regulation of genes for bone cell (osteoblast) markers

The primary research interest in Dr. Pavlin's laboratory is in regulation of genes for bone cell (osteoblast) markers. In particular, the focus is on molecular mechanisms involved in mechanically-induced regulation of bone cell markers, including the type I collagen, osteocalcin, alkaline phosphatase, bone morphogenetic proteins and homeobox-containing genes. For these studies, his group has developed an animal model in which the pattern of gene expression is monitored in subsets of periodontal cells within mechanically stimulated periodontium of transgenic mice.  This model system allows for monitoring of a temporal pattern of expression of osteoblast markers in vivo, with a long term goal of mapping the regions within the type I collagen and osteocalcin promoters involved in the process of transduction of an external mechanical signal into a gene regulatory event (mechanotransduction).  His laboratory is also utilizing a cell culture model of immortalized bone cell lines from transgenic mice subject to different components of mechanical stress.  These cell lines are supplementing the transgenic mouse model and allow for examination of the effects of single components of mechanical stress, i.e. the unilateral strain, hydrostatic pressure and fluid shear stress, on regulation of osteoblast-specific genes.  Supplementing the animal model with cloned cell lines facilitates characterization of regulatory mechanisms involved in mechanotransduction in bone, which are essential for the process of bone remodeling in physiological conditions and in bone disease.

  • Education
  • Appointments
  • Expertise
  • Teaching

Education

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Year Degree Discipline Institution
1992 PhD Biomedical Sciences University of Connecticut
1986 Residency Clinical Specialty in Orthodontics University of Connecticut
Farmington , CT
1975 Residency General Practice Polyclinic of Dentistry, Univ. of Zagreb
Croatia
1973 DMD Dentistry University of Zagreb, Croatia

Appointments

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9/2011 - Present Professor University of Texas Health Science Center - San Antonio, San Antonio, TX
6/2008 - Present Visiting Professor University of Zagreb, Dental School, Croatia
8/2007 - Present Director of the Orthodontic Residency Program and Orthodontic Clinic UTHSCSA, San Antonio, TX

Expertise

Orthodontic Biomechanics, Clinical Research -
Teaching and conducting clinical trials on function and modifications of orthodontic appliances.
Research in Bone Biology -
Gene regulation in bone during mechanical loading.

Teaching

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Date Description Institution # Students
- Present Pre-Doctoral Student Supervision
9/2011 - Present Masters' Thesis Directed University of Texas Health Science Center-San Antonio
9/2011 - Present Post-Doctoral Student Supervision University of Texas Health Science Center-San Antonio
9/2011 - Present Masters' Thesis Directed University of Texas Health Science Center-San Antonio
10/2010 - Present Masters' Thesis Directed University of Texas Health Science Center-San Antonio
10/2010 - Present Post-Doctoral Student Supervision University of Texas Health Science Center-San Antonio
3/2010 - Present Post-Doctoral Student Supervision UTHSCSA
3/2010 - Present Post-Doctoral Student Supervision University of Texas Health Science Center-San Antonio
10/2009 - Present Masters' Thesis Directed UTHSCSA
1/2009 - Present Post-Doctoral Student Supervision UTHSCSA
9/2001 - Present UTHSCSA

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